M. Bednarz

发表

Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.

Alan G. E. Wilson, D. Augeri, S. D. Kimball, 2009, Journal of medicinal chemistry.

BMS-196085: a potent and selective full agonist of the human beta(3) adrenergic receptor.

A. Mathur, T. Waldron, K. Dickinson, 2001, Bioorganic & medicinal chemistry letters.

Dual metalloprotease inhibitors: mercaptoacetyl-based fused heterocyclic dipeptide mimetics as inhibitors of angiotensin-converting enzyme and neutral endopeptidase.

N. Trippodo, H. Cheung, R. Misra, 1997, Journal of medicinal chemistry.

Process Development for a Locally Acting SGLT1 Inhibitor, LX2761, Utilizing sp3–sp2 Suzuki Coupling of a Benzyl Carbonate

B. Harrison, Lauren E. Sirois, Ngiap-Kie Lim, 2019, Organic Process Research & Development.

Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists.

J. Y. Roberge, Roy J. Vaz, R. Seethala, 2005, Bioorganic & medicinal chemistry letters.

Process Development of Tryptophan Hydroxylase Inhibitor LX1031, a Drug Candidate for the Treatment of Irritable Bowel Syndrome

S. Iimura, Haiming Zhang, Ngiap-Kie Lim, 2020 .

Inhibition of sphingosine 1-phosphate lyase for the treatment of rheumatoid arthritis: discovery of (E)-1-(4-((1R,2S,3R)-1,2,3,4-tetrahydroxybutyl)-1H-imidazol-2-yl)ethanone oxime (LX2931) and (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol (LX2932).

Alan G. E. Wilson, W. K. Sonnenburg, D. Augeri, 2010, Journal of medicinal chemistry.

One-pot synthesis of 4-substituted 3-amino-2-cyanothiophenes involving O-ethyl thioformate.

Haiming Zhang, Ngiap-Kie Lim, M. Bednarz, 2014, Organic letters.

A modified approach to 2-(N-aryl)-1,3-oxazoles: application to the synthesis of the IMPDH inhibitor BMS-337197 and analogues.

Henry H. Gu, E. Iwanowicz, W. Pitts, 2002, Organic letters.

A new facile method for the synthesis of 1-arylimidazole-5-carboxylates

Ping Chen, J. Barrish, Zhongqi Shen, 2000 .

Process Development of Sotagliflozin, a Dual Inhibitor of Sodium–Glucose Cotransporter-1/2 for the Treatment of Diabetes

S. Iimura, Youchu Wang, Xiaodong Gu, 2020 .

N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agent.

Punit Marathe, John S Tokarski, J. Tokarski, 2004, Journal of medicinal chemistry.

Novel triethylsilane mediated reductive N-alkylation of amines: improved synthesis of 1-(4-imidazolyl)methyl-4-sulfonylbenzodiazepines, new farnesyltransferase inhibitors

P. Guo, Bang-Chi Chen, R. Zhao, 2001 .

A Facile Method for the Transformation of N-(tert-Butoxycarbonyl) α-Amino Acids to N-Unprotected α-Amino Methyl Esters

O. Kocy, G. Vite, A. P. Skoumbourdis, 1999 .

Reaction of quinoxalin-2-ones with TosMIC reagent: synthesis of imidazo[1,5-a]quinoxalin-4-ones

Ping Chen, James Lin, E. Iwanowicz, 2001 .

A new highly enantioselective synthesis of both (R)- and (S)-2-mercaptosuccinic acids

O. Kocy, Bang-Chi Chen, M. Bednarz, 1998 .

A new strategy for the construction of the imidazo[1,5-a]quinoxalin-4-one ring system and its application to the efficient synthesis of BMS-238497, a novel and potent Lck inhibitor.

J. Barrish, Bang-Chi Chen, R. Zhao, 2004, The Journal of organic chemistry.

Practical synthesis of potent sphingosine-1-phosphate lyase inhibitors THI and LX2931

C. Guohua, Weifeng Hu, Renmao Liu, 2013 .

Synthesis of deuterium-labeled atorvastatin and its metabolites for use as internal standards in a LC/MS/MS method developed for quantitation of the drug and its metabolites in human serum

M. Jemal, P. Guo, Bang-Chi Chen, 2000 .

Discovery of (R)-7-cyano-2,3,4, 5-tetrahydro-1-(1H-imidazol-4-ylmethyl)-3- (phenylmethyl)-4-(2-thienylsulfonyl)-1H-1,4-benzodiazepine (BMS-214662), a farnesyltransferase inhibitor with potent preclinical antitumor activity.

S. Chong, J. Hunt, Soong-Hoon Kim, 2000, Journal of medicinal chemistry.

Rapid synthesis of triazine inhibitors of inosine monophosphate dehydrogenase.

D. Cheney, Henry H. Gu, E. Iwanowicz, 2002, Bioorganic & medicinal chemistry letters.

Discovery of N-[2-[2-[[3-methoxy-4-(5-oxazolyl)phenyl]amino]-5-oxazolyl]phenyl]-N-methyl-4- morpholineacetamide as a novel and potent inhibitor of inosine monophosphate dehydrogenase with excellent in vivo activity.

D. Cheney, Henry H. Gu, E. Iwanowicz, 2002, Journal of medicinal chemistry.

A Facile Method for the Transformation of N-(tert-Butoxycarbonyl) α-Amino Acids to N-Unprotected α-Amino Methyl Esters.

O. Kocy, G. Vite, P. Guo, 2000 .

A new efficient synthesis of N-(2-(2-(3-methoxy-4-(oxazol-5-yl)phenylamino)oxazol-5-yl)phenyl)-N-methyl-2-morpholinoacetamide (BMS-337197), A novel IMPDH inhibitor

E. Iwanowicz, J. Barrish, A. P. Skoumbourdis, 2007 .

Synthesis of d3-cerivastatin for use as internal standard in a LC/MS/MS method developed for quantitation of the drug in human serum

J. Barrish, M. Jemal, J. Robl, 2006 .

Inhibition of sphingosine-1-phosphate lyase for the treatment of autoimmune disorders.

Alan G. E. Wilson, D. Augeri, J. Tarver, 2009, Journal of medicinal chemistry.