Patrick Lee

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Pro-oncogenic cell signaling machinery as a target for oncolytic viruses.

F. Farassati, T. Esfandyari, D. Hawkinson, 2012, Current pharmaceutical biotechnology.

Oncogenes in Ras signalling pathway dictate host-cell permissiveness to herpes simplex virus 1

F. Farassati, An-Dao Yang, Patrick Lee, 2001, Nature Cell Biology.

A novel intravesical therapy for superficial bladder cancer in an orthotopic model: oncolytic reovirus therapy.

Ronald B. Moore, Z. Xiao, R. Britten, 2004, The Journal of urology.

All that glitters is not gold: the need to consider desirable and undesirable immune aspects of oncolytic virus therapy

D. Clements, S. Gujar, Youra Kim, 2016, Oncoimmunology.

Reovirus the Therapeutic Administration of Oncolytic Immunosuppression Immediately following Myeloid Cells Augment Tumor-Associated high , Ly 6 C + , GR-1 + Newly Recruited CD 11 b

P. Marcato, C. Dean, T. Sharif, 2015 .

Two is better than one

D. Clements, S. Gujar, Patrick Lee, 2014, Oncoimmunology.

Oncolytic Reovirus against Ovarian and Colon Cancer 1

K. Norman, K. Hirasawa, S. Nishikawa, 2002 .

Lymphomas and oncolytic virus therapy.

T. Alain, A. Kossakowska, C. Thirukkumaran, 2003, Clinical lymphoma.

The α-anomeric form of sialic acid is the minimal receptor determinant recognized by reovirus

A. Choi, R. Paul, Patrick Lee, 1989 .

Does the β-adrenergic receptor function as a reovirus receptor?

A. Choi, Patrick Lee, 1988 .

Subversion of autophagy by Kaposi's sarcoma-associated herpesvirus impairs oncogene-induced senescence.

R. Hill, Andrew M. Leidal, C. McCormick, 2012, Cell host & microbe.

mechanism selective chemotaxis of natural killer cells by a CXCL8-dependent Human mast cell activation with virus-associated stimuli leads to the

M. Shmulevitz, T. Issekutz, S. Burke, 2010 .

Human mast cell activation with virus-associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8-dependent mechanism.

M. Shmulevitz, T. Issekutz, J. Marshall, 2008, Blood.

Virus-Infected Human Mast Cells Enhance Natural Killer Cell Functions

J. Marshall, L. Portales-Cervantes, I. Haidl, 2016, Journal of Innate Immunity.

The reovirus cell attachment protein possesses two independently active trimerization domains: Basis of dominant negative effects

G. Leone, Patrick Lee, Lloyd Maybaum, 1992, Cell.

Reovirus Variants with Mutations in Genome Segments S1 and L2 Exhibit Enhanced Virion Infectivity and Superior Oncolysis

S. Gujar, M. Shmulevitz, D. Ahn, 2012, Journal of Virology.

Biochemical and biophysical characterization of the reovirus cell attachment protein σ1: Evidence that it is a homotrimer

J. Strong, Rajendra K. Sharma, R. Duncan, 1991, Virology.

Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells.

C. Giacomantonio, R. Hill, D. Hoskin, 2010, Cancer letters.

Curcumin induces apoptosis in HCT-116 human colon cancer cells in a p21-independent manner.

C. Giacomantonio, R. Hill, D. Hoskin, 2008, Experimental and molecular pathology.

Aldehyde dehydrogenase: Its role as a cancer stem cell marker comes down to the specific isoform

P. Marcato, C. Dean, C. Giacomantonio, 2011, Cell cycle.

The N-terminal heptad repeat region of reovirus cell attachment protein σ1 is responsible for σ1 oligomer stability and possesses intrinsic oligomerization function

R. Duncan, G. Leone, D. Mah, 1991, Virology.

Protein σ1 is the reovirus cell attachment protein

W. Joklik, E. Hayes, Patrick Lee, 1981 .

Reovirus Virotherapy Overrides Tumor Antigen Presentation Evasion and Promotes Protective Antitumor Immunity

P. Marcato, S. Gujar, D. Pan, 2010, Molecular Cancer Therapeutics.

Molecular Cancer apeutics apeutic Discovery virus Virotherapy Overrides Tumor Antigen Presentation Ther sion and Promotes Protective Antitumor Immunity

P. Marcato, A. Gujar, D. Pan, 2010 .

Efficacy and Safety Evaluation of Human Reovirus Type 3 in Immunocompetent Animals

K. Fonseca, S. Nishikawa, B. Thompson, 2004, Clinical Cancer Research.

Efficacy and Safety Evaluation of Human Reovirus Type 3 in Immunocompetent Animals: Racine and Nonhuman Primates

K. Fonseca, S. Nishikawa, B. Thompson, 2004 .

Oncolytic viral therapy for prostate cancer: efficacy of reovirus as a biological therapeutic.

K. Fonseca, M. Coffey, K. Hirasawa, 2010, Cancer research.

Single Amino Acid Differences between Closely Related Reovirus T3D Lab Strains Alter Oncolytic Potency In Vitro and In Vivo

D. Clements, S. Gujar, M. Shmulevitz, 2019, Journal of Virology.

Genetic Polymorphisms and Molecular Mechanisms Mediating Oncolytic Potency of Reovirus Strains

D. Clements, S. Gujar, M. Shmulevitz, 2019, bioRxiv.

Reovirus as an Oncolytic Agent

K. Norman, M. Patrick, Patrick Lee, 2005 .

Molecular cloning and sequencing of the reovirus (serotype 3) S1 gene which encodes the viral ceil attachment protein σ1

S. Masri, L. Nagata, D. Mah, 1984 .

Targeting cancer-initiating cells with oncolytic viruses.

P. Marcato, T. Cripe, Patrick Lee, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

How p53 binds DNA as a tetramer

K. McLure, P. C. Lee, K G McLure, 1998, The EMBO journal.

Aldehyde Dehydrogenase Activity of Breast Cancer Stem Cells Is Primarily Due To Isoform ALDH1A3 and Its Expression Is Predictive of Metastasis

Patrick W. Lee, P. Marcato, C. Dean, 2011, Stem cells.

Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies.

G. Kroemer, Patrick W. Lee, S. Gujar, 2017, Trends in immunology.

Autophagic homeostasis is required for the pluripotency of cancer stem cells

T. Sharif, D. Clements, S. Gujar, 2017, Autophagy.

Dendritic Cells in Oncolytic Virus-Based Anti-Cancer Therapy

A. Sterea, D. Clements, S. Gujar, 2015, Viruses.

Reovirus in cancer therapy: an evidence-based review

D. Clements, S. Gujar, E. Helson, 2014, Oncolytic virotherapy.

Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling

J. Mackey, Patrick W. Lee, P. Marcato, 2015, Molecular oncology.

DNA-dependent Protein Kinase and Checkpoint Kinase 2 Synergistically Activate a Latent Population of p53 upon DNA Damage*

Patrick W. Lee, Melissa T Jack, Richard A. Woo, 2004, Journal of Biological Chemistry.

Chk2 is dispensable for p53-mediated G1 arrest but is required for a latent p53-mediated apoptotic response

T. Mak, Patrick W. Lee, A. Cheung, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Unshackling the links between reovirus oncolysis, Ras signaling, translational control and cancer

P. Marcato, M. Shmulevitz, Patrick Lee, 2005, Oncogene.

Potentiating prostate cancer immunotherapy with oncolytic viruses

S. Gujar, Patrick Lee, 2018, Nature Reviews Urology.

Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1

Amos S Hundert, I. Weaver, P. Marcato, 2016, Oncotarget.

Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10

P. Madureira, D. Waisman, P. O'Connell, 2016, Oncotarget.

Reovirus prolongs survival and reduces the frequency of spinal and leptomeningeal metastases from medulloblastoma.

T. Curran, C. Wetmore, J. Wolff, 2003, Cancer research.

binding to p 53 on the p 21 WAF 1 / CIP 1 promoter blocks transcription resulting in cell death

P. Madureira, D. Waisman, R. Hill, 2012 .

DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death

P. Madureira, D. Waisman, R. Hill, 2011, Oncotarget.

Core Needle Biopsy of Breast Cancer Tumors Increases Distant Metastases in a Mouse Model12

Patrick W. Lee, P. Marcato, C. Dean, 2014, Neoplasia.

The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?

R. Hill, Patrick Lee, 2010, Cell cycle.

Reovirus oncolysis: the Ras/RalGEF/p38 pathway dictates host cell permissiveness to reovirus infection.

K. Norman, K. Hirasawa, Michael A Shields, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Oncogenic Ras promotes reovirus spread by suppressing IFN-beta production through negative regulation of RIG-I signaling.

M. Shmulevitz, D. Pan, L. Pan, 2010, Cancer research.

Ras transformation mediates reovirus oncolysis by enhancing virus uncoating, particle infectivity, and apoptosis-dependent release.

P. Marcato, M. Shmulevitz, D. Stoltz, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

The molecular basis of viral oncolysis: usurpation of the Ras signaling pathway by reovirus

M. Coffey, J. Strong, D. Tang, 1998, The EMBO journal.

Exploring host factors that impact reovirus replication, dissemination, and reovirus-induced cell death in cancer versus normal cells in culture.

M. Shmulevitz, Patrick Lee, 2012, Methods in molecular biology.

Hsp90 Phosphorylation Is Linked to Its Chaperoning Function

R. Gilmore, G. Leone, Patrick Lee, 2001, The Journal of Biological Chemistry.

Oncolytic reovirus effectively targets breast cancer stem cells.

Patrick W. Lee, P. Marcato, C. Dean, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

If cancer stem cells are resistant to current therapies, what's next?

P. Marcato, C. Dean, C. Giacomantonio, 2009, Future oncology.

Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages

S. Gygi, J. Paulo, Patrick W. Lee, 2017, Journal of proteome research.

Sharpening the Edge for Precision Cancer Immunotherapy: Targeting Tumor Antigens through Oncolytic Vaccines

S. Gujar, Youra Kim, Namit Holay, 2017, Front. Immunol..

Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo

J. Fox, M. Hollenberg, M. Gill, 2010, Antiviral therapy.

Activation of p53 by Chemotherapeutic Agents Enhances Reovirus Oncolysis

P. Marcato, S. Gujar, M. Shmulevitz, 2013, PloS one.

Connecting Reovirus Oncolysis and Ras Signaling

P. Marcato, M. Shmulevitz, Patrick Lee, 2005, Cell cycle.

HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells

C. Giacomantonio, T. Sharif, S. Gujar, 2018, Autophagy.

UV-dependent Alternative Splicing Uncouples p53 Activity and PIG3 Gene Function through Rapid Proteolytic Degradation*

C. Nicholls, Michael A Shields, S. Robbins, 2004, Journal of Biological Chemistry.

Chromium-mediated apoptosis: involvement of DNA-dependent protein kinase (DNA-PK) and differential induction of p53 target genes.

Arthur N. L. Chiu, P. Madureira, D. Waisman, 2008, DNA repair.

Biogenesis of p53 Involves Cotranslational Dimerization of Monomers and Posttranslational Dimerization of Dimers

Patrick W. Lee, K. McLure, C. Nicholls, 2002, The Journal of Biological Chemistry.

DNA-dependent protein kinase acts upstream of p53 in response to DNA damage

Derrick E. Rancourt, Patrick W. Lee, K. McLure, 1998, Nature.

p21Cip1/WAF1 mediates cyclin B1 degradation in response to DNA damage

R. Hill, Andrew M. Leidal, Patrick Lee, 2009, Cell cycle.

p53 binding to the p21 promoter is dependent on the nature of DNA damage

R. Hill, M. Blough, Patrick Lee, 2008, Cell cycle.

The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target

T. Sharif, D. Clements, S. Gujar, 2014, Cell cycle.

Oncolytic Virus-Mediated Reversal of Impaired Tumor Antigen Presentation

S. Gujar, Patrick Lee, 2014, Front. Oncol..

Hypersensitivity to chromium-induced DNA damage correlates with constitutive deregulation of upstream p53 kinases in p21-/- HCT116 colon cancer cells.

Arthur N. L. Chiu, P. Madureira, D. Waisman, 2008, DNA repair.

The Rocky Road from Cancer Stem Cell Discovery to Diagnostic Applicability

P. Marcato, Patrick Lee, 2011 .

Newly Recruited CD11b+, GR-1+, Ly6Chigh Myeloid Cells Augment Tumor-Associated Immunosuppression Immediately following the Therapeutic Administration of Oncolytic Reovirus

Patrick W. Lee, P. Marcato, C. Dean, 2015, The Journal of Immunology.

NAD+ salvage pathway in cancer metabolism and therapy.

T. Sharif, S. Gujar, Youra Kim, 2016, Pharmacological research.

Oncolytic Virus-initiated Protective Immunity Against Prostate Cancer.

P. Marcato, S. Gujar, D. Pan, 2011, Molecular therapy : the journal of the American Society of Gene Therapy.

Systemic reovirus therapy of metastatic cancer in immune-competent mice.

K. Norman, M. Coffey, K. Hirasawa, 2003, Cancer research.

Not all viruses are bad guys: the case for reovirus in cancer therapy.

K. Norman, Patrick Lee, 2005, Drug discovery today.

MHC-I Ligand Discovery Using Targeted Database Searches of Mass Spectrometry Data: Implications for T-Cell Immunotherapies.

Morten Nielsen, Prathyusha Konda, Shashi Gujar, 2017, Journal of proteome research.

Reovirus therapy of lymphoid malignancies.

K. Hirasawa, S. Nishikawa, T. Alain, 2002, Blood.

Reovirus oncolysis of human breast cancer.

K. Norman, M. Coffey, K. Hirasawa, 2002, Human gene therapy.

Oncolytic reovirus against ovarian and colon cancer.

K. Norman, K. Hirasawa, S. Nishikawa, 2002, Cancer research.

Structure-Function Relationships of the Reovirus Cell-Attachment Protein σ1

Patrick W. Lee, Patrick Lee, 1992 .

Genotoxic Agents Promote the Nuclear Accumulation of Annexin A2: Role of Annexin A2 in Mitigating DNA Damage

Patrick W. Lee, P. Madureira, D. Waisman, 2012, PloS one.

Transcription factors down‐stream of Ras as molecular indicators for targeting malignancies with oncolytic herpes virus

T. Alain, A. Tefferi, F. Farassati, 2009, Molecular oncology.

Selective reovirus killing of bladder cancer in a co-culture spheroid model.

Ronald B. Moore, Y. Tamimi, S. Karmali, 2003, Virus research.

Regulation of Cancer and Cancer-Related Genes via NAD.

T. Sharif, S. Gujar, Barry E. Kennedy, 2018, Antioxidants & redox signaling.

Ras Signalling Pathway: A Gateway for HSV-1 Infection

F. Farassati, Patrick Lee, 2003, TheScientificWorldJournal.

Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.

P. Marcato, D. Clements, S. Gujar, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.

962. The Ras/Raf-1/MEK/ERK Signaling Pathway Dictates Host Cell Permissiveness to VSV Infection

Y. Ikeda, R. Sakuma, J. A. Noser, 2006 .

The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: implication for the defective interferon response in cancer cells.

P. Marcato, Y. Ikeda, R. Sakuma, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Identification of the Essential Role of Viral Bcl-2 for Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication

B. Oh, Patrick W. Lee, Jae U. Jung, 2015, Journal of Virology.

Viral subversion of autophagy impairs oncogene-induced senescence

Andrew M. Leidal, C. McCormick, Patrick Lee, 2012, Autophagy.

Reovirus Therapy of Ras-Associated Cancers

Patrick W. Lee, Patrick Lee, 2002 .

Purification and characterization of the reovirus cell attachment protein σ1

Patrick W. Lee, M. Gill, M. C. Yeung, 1987 .

Reovirus therapy of tumors with activated Ras pathway.

M. Coffey, J. Strong, P. Forsyth, 1998, Science.

Ras transformation results in cleavage of reticulon protein Nogo-B that is associated with impairment of IFN response

Patrick W. Lee, T. Sharif, K. Chisholm, 2015, Cell cycle.

DNA damage‐induced apoptosis requires the DNA‐dependent protein kinase, and is mediated by the latent population of p53

David J. Chen, S. Burma, Richard A. Woo, 2013 .

Attenuated reovirus displays oncolysis with reduced host toxicity

T. Alain, P. C. Lee, D. Rancourt, 2010, British Journal of Cancer.

The oncolytic effect in vivo of reovirus on tumour cells that have survived reovirus cell killing in vitro

T. Alain, A. Kossakowska, R. Johnston, 2006, British Journal of Cancer.

The v-erbB oncogene confers enhanced cellular susceptibility to reovirus infection

J. Strong, Patrick Lee, P. Lee, 1996, Journal of virology.

Reovirus as a novel oncolytic agent.

K. Norman, Patrick Lee, P. Lee, 2000, The Journal of clinical investigation.

Retraction: DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death

P. Madureira, D. Waisman, R. Hill, 2019, Oncotarget.

The NAD+ salvage pathway modulates cancer cell viability via p73

M. Kwak, P. Marcato, C. Dean, 2015, Cell Death and Differentiation.

Reovirus Variants with Mutations in Genome Segments S1 and L2 Exhibit Enhanced Virion Infectivity and Superior Oncolysis

S. Gujar, M. Shmulevitz, Adil Mohamed, 2012, Journal of Virology.

Trimerization of the reovirus cell attachment protein (σI) induces conformational changes in σI necessary for its cell-binding function

R. Duncan, G. Leone, Patrick Lee, 1991 .

Subversion of Autophagy by Kaposi's Sarcoma-Associated Herpesvirus Impairs Oncogene-Induced Senescence.

R. Hill, Andrew M. Leidal, C. McCormick, 2016, Cell host & microbe.

MHC-I Ligand Discovery Using Targeted Database Searches of Mass Spectrometry Data: Implications for T-Cell Immunotherapies.

S. Stevanović, M. Nielsen, D. Clements, 2017, Journal of proteome research.

Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation.

P. Marcato, D. Clements, S. Gujar, 2013, Molecular therapy : the journal of the American Society of Gene Therapy.