M. A. Dombroski

发表

Preclinical pharmacokinetics and metabolism of 6‐(4‐(2,5‐difluorophenyl)oxazol‐5‐yl)‐3‐isopropyl‐[1,2,4]‐triazolo[4,3‐a]pyridine, a novel and selective p38α inhibitor: identification of an active metabolite in preclinical species and human liver microsomes

A. Kalgutkar, E. Choo, K. McClure, 2006, Biopharmaceutics & drug disposition.

Identification and characterization of a novel class of interleukin-1 post-translational processing inhibitors.

C. Gabel, D. Perregaux, J. Eggler, 2001, The Journal of pharmacology and experimental therapeutics.

Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development.

F. Lombardo, A. Kalgutkar, E. Laird, 2006, Bioorganic & medicinal chemistry letters.

Optimization of the physicochemical and pharmacokinetic attributes in a 6-azauracil series of P2X7 receptor antagonists leading to the discovery of the clinical candidate CE-224,535.

A. Kalgutkar, C. Gabel, R. Shepard, 2011, Bioorganic & medicinal chemistry letters.

Discovery, synthesis and SAR of azinyl- and azolylbenzamides antagonists of the P2X₇ receptor.

C. Gabel, R. Shepard, D. Perregaux, 2011, Bioorganic & medicinal chemistry letters.

Manganese(III)-based oxidative free-radical tandem and triple cyclizations

B. Snider, S. Kates, M. A. Dombroski, 1990 .

Cyclizations of unsaturated .bul.CR(COX)2 radicals. Manganese(III) acetate oxidative cyclizations of unsaturated acetoacetates and atom-transfer cyclizations of unsaturated haloacetoacetates give the same radicals

D. Curran, B. Snider, C. Schwartz, 1991 .

Solvent effects on manganese(III)-based oxidative free-radical cyclizations: ethanol and acetic acid

B. Buckman, B. Snider, J. Merritt, 1991 .

Theoretical and experimental design of atypical kinase inhibitors: application to p38 MAP kinase.

Dennis E Danley, P. Lemotte, M. Mansour, 2005, Journal of medicinal chemistry.

Manganese(III)-based oxidative free-radical cyclization of unsaturated .beta.-keto esters, 1,3-diketones, and malonate diesters

B. Snider, S. Kates, M. A. Dombroski, 1990 .

Aldol condensations of ethyl 1,3-dithiolane-2-carsoxylate and ethyl 1,3-dithiane-2-carboxylate with chiral aldehydes. Exceptional diastereoface selectivity from two convenient acetate equivalents.

L. Flippin, M. A. Dombroski, 1985 .

Synthesis of covalent [14C]-labeled diarylsulfonylurea (DASU) inhibitors of the processing and release of IL-1

C. Gabel, J. Weaver, J. Eggler, 2002 .

Glutathione S-Transferase Omega 1-1 Is a Target of Cytokine Release Inhibitory Drugs and May Be Responsible for Their Effect on Interleukin-1β Posttranslational Processing*

C. Gabel, K. Geoghegan, P. Rosner, 2003, The Journal of Biological Chemistry.

Benzimidazolone p38 inhibitors.

C. Gabel, T. Carty, John T Barberia, 2004, Bioorganic & medicinal chemistry letters.

Glutathione s-transferase omega 1-1 is a target of cytokine release inhibitory drugs and may be responsible for their effect on interleukin-1beta posttranslational processing.

C. Gabel, K. Geoghegan, P. Rosner, 2003, The Journal of biological chemistry.

Dichloroethylaluminum-catalyzed reactions of alkenes with electrophilic cyclopropanes. A new cyclopentane annelation reaction

B. Snider, R. Beal, M. A. Dombroski, 1986 .

Orally active and brain permeable proline amides as highly selective 5HT2c agonists for the treatment of obesity.

K. Liu, B. Lefker, Janice A. Brown, 2010, Bioorganic & medicinal chemistry letters.

Manganese (III) based oxidative free-radical cyclizations. 3. Polycyclization reactions proceeding through secondary radicals.

B. Snider, Raju Mohan, S. Kates, 1987 .

Mn(III)-based oxidative free-radical cyclizations of ?,?-bis(allylic) acetoacetates

M. A. Dombroski, 1992 .

Manganese(III) Based Oxidative Free‐Radical Cyclizations. Part 3. Polycyclization Reactions Proceeding Through Secondary Radicals.

B. Snider, Raju Mohan, S. Kates, 1987 .

Mn(III)-Based Oxidative Free-Radical Cyclizations of γ,γ- Bis(allylic) Acetoacetates.

B. Snider, M. A. Dombroski, 1992 .

Cyclizations of Unsaturated ×CR(COX)2 Radicals. Manganese(III) Acetate Oxidative Cyclizations of Unsaturated Acetoacetates and Atom- Transfer Cyclizations of Unsaturated Haloacetoacetates Give the Same Radicals.

D. Curran, B. Snider, C. Schwartz, 1991 .

Manganese(III)-based oxidative free radical cyclizations. 5. Termination of polycyclization by oxidative .beta.-hydride elimination

B. Snider, M. A. Dombroski, 1987 .

Manganese(III)-Based Oxidative Free Radical Cyclizations. Part 5. Termination of Polycyclization by Oxidative β-Hydride Elimination.

B. Snider, M. A. Dombroski, 1988 .