B. Youssif

发表

Globally Approved EGFR Inhibitors: Insights into Their Syntheses, Target Kinases, Biological Activities, Receptor Interactions, and Metabolism

Alaa M. Alqahtani, A. Gouda, Bahaa G. M. Youssif, 2021, Molecules.

New 1,2,4‐oxadiazole/pyrrolidine hybrids as topoisomerase IV and DNA gyrase inhibitors with promising antibacterial activity

A. Abdelazeem, Chunli Wu, H. Gomaa, 2022, Archiv der Pharmazie.

Linseed hydrogel-mediated green synthesis of silver nanoparticles for antimicrobial and wound-dressing applications

S. Bashir, S. Yuk, S. N. Bukhari, 2017, International journal of nanomedicine.

Design and synthesis of new 1,6-dihydropyrimidin-2-thio derivatives targeting VEGFR-2: Molecular docking and antiproliferative evaluation.

A. Gouda, M. Abdel-Aziz, Adel A Marzouk, 2020, Bioorganic chemistry.

Synthesis and mechanistic studies of curcumin analog‐based oximes as potential anticancer agents

Z. Hussain, S. N. Bukhari, M. Amjad, 2017, Chemical biology & drug design.

Novel fluoroquinolone hybrids as dual DNA gyrase and urease inhibitors with potential antibacterial activity: Design, synthesis, and biological evaluation

Katarina Cirnski, J. Herrmann, Ola I A Salem, 2022, Journal of Molecular Structure.

Synthesis and Biological Evaluation of Indole-2-Carboxamides with Potent Apoptotic Antiproliferative Activity as EGFR/CDK2 Dual Inhibitors

Yaser A. Mostafa, Ali H El-Bahrawy, L. H. Al-Wahaibi, 2022, Pharmaceuticals.

Design and Synthesis of (2-oxo-1,2-Dihydroquinolin-4-yl)-1,2,3-triazole Derivatives via Click Reaction: Potential Apoptotic Antiproliferative Agents

Ahmed M. Shawky, S. Bräse, E. El-Sheref, 2021, Molecules.

Design, synthesis, mechanistic and histopathological studies of small-molecules of novel indole-2-carboxamides and pyrazino[1,2-a]indol-1(2H)-ones as potential anticancer agents effecting the reactive oxygen species production.

M. Abdelgawad, S. N. Bukhari, A. Abdelazeem, 2018, European journal of medicinal chemistry.

Structure-based design, synthesis, and biological evaluation of novel piperine–resveratrol hybrids as antiproliferative agents targeting SIRT-2

Xiang-gao Meng, Manqun Wang, A. Abdelazeem, 2021, RSC advances.

Novel 1,5-diaryl pyrazole-3-carboxamides as selective COX-2/sEH inhibitors with analgesic, anti-inflammatory, and lower cardiotoxicity effects.

Sami I. Alzarea, F. Mohamed, A. Abdelazeem, 2021, Bioorganic chemistry.

Novel quinoline derivatives carrying nitrones/oximes nitric oxide donors: Design, synthesis, antiproliferative and caspase‐3 activation activities

M. Ramadan, M. Abdelrahman, B. Youssif, 2018, Archiv der Pharmazie.

Synthesis of novel amidines via one-pot three component reactions: Selective topoisomerase I inhibitors with antiproliferative properties

S. Bräse, Alaa A. Hassan, Hendawy N Tawfeek, 2022, Frontiers in Chemistry.

Novel pyrrol-2(3H)-ones and pyridazin-3(2H)-ones carrying quinoline scaffold as anti-proliferative tubulin polymerization inhibitors.

S. N. Bukhari, M. Ramadan, G. Abuo-Rahma, 2018, Bioorganic chemistry.

Novel piperine-carboximidamide hybrids: design, synthesis, and antiproliferative activity via a multi-targeted inhibitory pathway

Yaser A. Mostafa, L. H. Al-Wahaibi, M. A. Mahmoud, 2022, Journal of enzyme inhibition and medicinal chemistry.

Novel 1,2,4-triazole derivatives as potential anticancer agents: Design, synthesis, molecular docking and mechanistic studies.

S. N. Bukhari, H. Abdel-Rahman, H. A. El-Sherief, 2018, Bioorganic chemistry.

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors

A. A. Abdelhamid, A. A. Amer, Adel A Marzouk, 2021, Pharmaceuticals.

Design, synthesis and antitrypanosomal activity of heteroaryl-based 1,2,4-triazole and 1,3,4-oxadiazole derivatives.

A. Gouda, M. Radwan, Adel A Marzouk, 2020, Bioorganic chemistry.

New quinoline/1,2,4-triazole hybrids as dual inhibitors of COX-2/5-LOX and inflammatory cytokines: Design, synthesis, and docking study

Heba A. Hassan, M. Otsuka, A. Gouda, 2021 .

Novel 1,2,4-triazole derivatives as apoptotic inducers targeting p53: Synthesis and antiproliferative activity.

A. Gouda, K. S. Alharbi, H. Gomaa, 2020, Bioorganic chemistry.

Synthesis, anticancer activity and molecular modeling studies of 1,2,4-triazole derivatives as EGFR inhibitors.

A. Abdelazeem, H. Abdel-Rahman, H. A. El-Sherief, 2018, European journal of medicinal chemistry.

Synthesis and In Vitro Antiproliferative Activity of New 1-Phenyl-3-(4-(pyridin-3-yl)phenyl)urea Scaffold-Based Compounds

N. Omar, M. M. Al-Sanea, M. E. Shaker, 2018, Molecules.

Discovery of new pyrimido[5,4-c]quinolines as potential antiproliferative agents with multitarget actions: Rapid synthesis, docking, and ADME studies.

Yaser A. Mostafa, R. Mekheimer, M. Moustafa, 2022, Bioorganic chemistry.

Design, synthesis and pharmacophoric model building of new 3‐alkoxymethyl/3‐phenyl indole‐2‐carboxamides with potential antiproliferative activity

B. Elsadek, M. Abdelrahman, B. Youssif, 2017, Chemical biology & drug design.

Structure-based design, synthesis and antiproliferative action of new quizoline-4-one/chalcone hybrids as EGFR inhibitors

Heba A. Hassan, M. Hisham, Heba A Hassan, 2022, Journal of Molecular Structure.

Design, Synthesis and Antiproliferative Evaluation of Novel 1,2,4-Triazole/Schiff Base Hybrids with EGFR and B-RAF Inhibitory Activities.

A. Abdelazeem, M. Abdel-Aziz, H. Abdel-Rahman, 2019, Anti-cancer agents in medicinal chemistry.

Design, synthesis, and biological evaluation of new series of pyrrol-2(3H)-one and pyridazin-3(2H)-one derivatives as tubulin polymerization inhibitors.

S. N. Bukhari, A. Gouda, M. Abdelrahman, 2020, Bioorganic chemistry.

Design, Synthesis, Biological Evaluation, and Computational Studies of Novel Tri-Aryl Imidazole-Benzene Sulfonamide Hybrids as Promising Selective Carbonic Anhydrase IX and XII Inhibitors

A. A. Abdelhamid, Ehab S. Taher, A. Abdelazeem, 2021, Molecules.

Novel diphenylthiazole derivatives with multi-target mechanism: Synthesis, docking study, anticancer and anti-inflammatory activities.

Samir M. El-Moghazy, A. Abdelazeem, H. Omar, 2017, Bioorganic chemistry.

Synthesis, biological evaluation and in silico ADME predictions of some new coumarin-acetamide derivatives as potent anti-inflammatory agents

A. Hayallah, M. Abdelrahman, Martha M. Morcoss, 2021, Bulletin of Pharmaceutical Sciences. Assiut.

Design, synthesis and biological evaluation of novel 5-((substituted quinolin-3-yl/1-naphthyl) methylene)-3-substituted imidazolidin-2,4-dione as HIV-1 fusion inhibitors.

Ehab S. Taher, N. Alhakamy, Mohamed Elagawany, 2020, Bioorganic chemistry.

Synthesis and anti-mycobacterial activity of 4-(4-phenyl-1H-1,2,3-triazol-1-yl)salicylhydrazones: revitalizing an old drug

P. Yogeeswari, D. Sriram, T. Aboul-Fadl, 2016, Archives of Pharmacal Research.

Synthesis and anti-mycobacterial activity of 4-(4-phenyl-1H-1,2,3-triazol-1-yl)salicylhydrazones: revitalizing an old drug

P. Yogeeswari, D. Sriram, T. Aboul-Fadl, 2016, Archives of Pharmacal Research.

Design and synthesis of new pyranoquinolinone heteroannulated to triazolopyrimidine of potential apoptotic antiproliferative activity.

A. Aly, Alan B. Brown, M. Ramadan, 2020, Bioorganic chemistry.

Design, Docking Studies, and Anticancer Activity of Newly Synthesized Monastrol Analogues Bearing Ligustrazine Moiety

A. Amr, A. Mohamed, N. A. Abdel-Hafez, 2022, Russian Journal of General Chemistry.

Synthesis, biological evaluation, docking study and ulcerogenicity profiling of some novel quinoline-2-carboxamides as dual COXs/LOX inhibitors endowed with anti-inflammatory activity.

M. Abdelgawad, S. N. Bukhari, A. Abdelazeem, 2017, European journal of medicinal chemistry.

Design and synthesis of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as antiproliferative EGFR and BRAFV600E dual inhibitors.

A. Gouda, Hatem S. Farghaly, L. Trembleau, 2020, Bioorganic chemistry.

Design, synthesis, and biological evaluation of new pyrimidine-5-carbonitrile derivatives bearing 1,3-thiazole moiety as novel anti-inflammatory EGFR inhibitors with cardiac safety profile.

Ehab S. Taher, P. Lan, Gihan F. Asaad, 2021, Bioorganic chemistry.

Design, synthesis, and modelling study of new 1,2,3‐triazole/chalcone hybrids with antiproliferative action as epidermal growth factor receptor inhibitors

Ola I A Salem, B. Youssif, M. Sheha, 2022, Chemical biology & drug design.

Optimization and SAR investigation of novel 2,3-dihydropyrazino[1,2-a]indole-1,4-dione derivatives as EGFR and BRAFV600E dual inhibitors with potent antiproliferative and antioxidant activities.

Sami I. Alzarea, F. Mohamed, M. E. Shaker, 2022, Bioorganic chemistry.

Design and synthesis of new triarylimidazole derivatives as dual inhibitors of BRAFV600E/p38α with potential antiproliferative activity

A. A. Abdelhamid, A. Gouda, Adel A Marzouk, 2021, Journal of Molecular Structure.

EGFR inhibitors and apoptotic inducers: Design, synthesis, anticancer activity and docking studies of novel xanthine derivatives carrying chalcone moiety as hybrid molecules.

M. Mohamed, A. Hayallah, B. Youssif, 2019, Bioorganic chemistry.

Novel aryl carboximidamide and 3-aryl-1,2,4-oxadiazole analogues of naproxen as dual selective COX-2/15-LOX inhibitors: Design, synthesis and docking studies.

A. A. Abdelhamid, M. M. Al-Sanea, M. Mohamed, 2019, Bioorganic chemistry.

Design, Synthesis and Biological Evaluation of New HDAC1 and HDAC2 Inhibitors Endowed with Ligustrazine as a Novel Cap Moiety

M. Abdelgawad, M. M. Al-Sanea, Wagdy M. Eldehna, 2020, Drug design, development and therapy.

Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance.

S. N. Bukhari, M. Amjad, M. Raja, 2017, European journal of medicinal chemistry.

Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors.

A. Aly, Alan B. Brown, M. Ramadan, 2019, Bioorganic chemistry.

New pyrimidine/thiazole hybrids endowed with analgesic, anti‐inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX‐2/sEH dual inhibition

Ehab S. Taher, P. Lan, H. Gomaa, 2022, Archiv der Pharmazie.

5-Chlorobenzofuran-2-carboxamides: From allosteric CB1 modulators to potential apoptotic antitumor agents.

A. Mohamed, H. Gomaa, M. Abdelrahman, 2019, European journal of medicinal chemistry.

Utilization of tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidinone as a cap moiety in design of novel histone deacetylase inhibitors.

G. Abuo-Rahma, M. S. Shaykoon, B. Elsadek, 2019, Bioorganic chemistry.

Design, synthesis, and biological evaluation of novel EGFR inhibitors containing 5-chloro-3-hydroxymethyl-indole-2-carboxamide scaffold with apoptotic antiproliferative activity.

F. Mohamed, A. Abdelazeem, A. Gouda, 2021, Bioorganic chemistry.

New 1,3,4‐oxadiazole‐chalcone/benzimidazole hybrids as potent antiproliferative agents

S. Abbas, H. Gomaa, Dalia Abdelhamid, 2022, Archiv der Pharmazie.

Design, synthesis, and antibacterial evaluation of new quinoline-1,3,4-oxadiazole and quinoline-1,2,4-triazole hybrids as potential inhibitors of DNA gyrase and topoisomerase IV.

M. Mohamed, H. Gomaa, N. El-Koussi, 2021, Bioorganic chemistry.

Design, Synthesis, and Antiproliferative Activity of New 5-Chloro-indole-2-carboxylate and Pyrrolo[3,4-b]indol-3-one Derivatives as Potent Inhibitors of EGFRT790M/BRAFV600E Pathways

L. H. Al-Wahaibi, M. Abdelrahman, L. Trembleau, 2023, Molecules.

Design, Synthesis, Antiproliferative Actions, and DFT Studies of New Bis–Pyrazoline Derivatives as Dual EGFR/BRAFV600E Inhibitors

A. Hayallah, L. H. Al-Wahaibi, B. Youssif, 2023, International journal of molecular sciences.

Design, Synthesis and Biological Evaluation of Syn and Anti-like Double Warhead Quinolinones Bearing Dihydroxy Naphthalene Moiety as Epidermal Growth Factor Receptor Inhibitors with Potential Apoptotic Antiproliferative Action

S. Bräse, H. Patel, E. El-Sheref, 2022, Molecules.

New 1,3,4‐oxadiazoles linked with the 1,2,3‐triazole moiety as antiproliferative agents targeting the EGFR tyrosine kinase

H. Gomaa, Ola I A Salem, M. A. Mahmoud, 2022, Archiv der Pharmazie.

Novel Benzyloxyphenyl Pyrimidine-5-Carbonitrile Derivatives as Potential Apoptotic Antiproliferative Agents.

Ehab S. Taher, N. Osman, T. Ibrahim, 2021, Anti-cancer agents in medicinal chemistry.

Design and synthesis of novel quinoline/chalcone/1,2,4-triazole hybrids as potent antiproliferative agent targeting EGFR and BRAFV600E kinases.

Heba A. Hassan, M. Otsuka, A. Gouda, 2020, Bioorganic chemistry.

Design, synthesis and antimicrobial activity of novel quinoline-2-one hybrids as promising DNA gyrase and topoisomerase IV inhibitors

F. Mohamed, H. Gomaa, I. Zaki, 2023, Journal of Molecular Structure.

Design, synthesis, and antiproliferative properties of new 1,2,3-triazole-carboximidamide derivatives as dual EGFR/VEGFR-2 inhibitors

M. A. Mahmoud, B. Youssif, Anber F. Mohammed, 2023, Journal of Molecular Structure.

Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAFV600E

M. Ramadan, F. Agili, H. Gomaa, 2023, Pharmaceuticals.

One-Pot Synthesis of 1-Thia-4-azaspiro[4.4/5]alkan-3-ones via Schiff Base: Design, Synthesis, and Apoptotic Antiproliferative Properties of Dual EGFR/BRAFV600E Inhibitors

E. El-Sheref, Bahaa G. M. Youssif, L. H. Al-Wahaibi, 2023, Pharmaceuticals.

Discovery of new cyanopyridine/chalcone hybrids as dual inhibitors of EGFR/BRAFV600E with promising antiproliferative properties

Yaser A. Mostafa, H. Gomaa, A. Hayallah, 2022, Archiv der Pharmazie.

Design, Synthesis, and Biological Evaluation of Indole-2-carboxamides as Potential Multi-Target Antiproliferative Agents

L. H. Al-Wahaibi, M. Abdelrahman, B. Youssif, 2023, Pharmaceuticals.

Discovery of new 5-substituted-indole-2-carboxamides as dual epidermal growth factor receptor (EGFR)/cyclin dependent kinase-2 (CDK2) inhibitors with potent antiproliferative action.

F. Mohamed, O. Hendawy, H. Gomaa, 2023, RSC medicinal chemistry.

Discovery of novel oxazole-based macrocycles as anti-coronaviral agents targeting SARS-CoV-2 main protease

Mahmoud M. Shehata, M. Ali, F. Mohamed, 2021, Bioorganic Chemistry.

Novel 1,2,4-oxadiazole/pyrrolidine hybrids as DNA gyrase and Topoisomerase IV inhibitors with potential antibacterial activity

Chunli Wu, H. Gomaa, Hong-ning Zhai, 2021, Arabian Journal of Chemistry.

Synthesis and Structure Determination of Substituted Thiazole Derivatives as EGFR/BRAFV600E Dual Inhibitors Endowed with Antiproliferative Activity

M. Nieger, Mahmoud A. A. Ibrahim, E. El-Sheref, 2023, Pharmaceuticals.

Novel indazole derivatives as potent apoptotic antiproliferative agents by multi-targeted mechanism: Synthesis and biological evaluation.

Yaser A. Mostafa, Chunli Wu, H. Gomaa, 2022, Bioorganic chemistry.

Discovery and optimization of 2,3-diaryl-1,3-thiazolidin-4-one-based derivatives as potent and selective cytotoxic agents with anti-inflammatory activity.

Ahmed M. Shawky, F. Almalki, Ashraf N. Abdalla, 2023, European journal of medicinal chemistry.

Synthesis, Antioxidant and Antiproliferative Actions of 4-(1,2,3-Triazol-1-yl)quinolin-2(1H)-ones as Multi-Target Inhibitors

E. El-Sheref, F. Alasmary, B. Youssif, 2023, International journal of molecular sciences.

Synthesis of bis-thiohydantoin derivatives as an antiproliferative agents targeting EGFR inhibitory pathway.

M. Nieger, A. Aly, N. Mohamed, 2023, Molecular diversity.

Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance.

S. N. Bukhari, M. Amjad, M. Raja, 2017, European journal of medicinal chemistry.

Chalcone/1,3,4-Oxadiazole/Benzimidazole hybrids as novel anti-proliferative agents inducing apoptosis and inhibiting EGFR & BRAFV600E

S. Abbas, H. Gomaa, Dalia Abdelhamid, 2023, BMC Chemistry.

Novel Pyrazoloquinolin-2-ones: Design, synthesis, docking studies, and biological evaluation as antiproliferative EGFR-TK inhibitors.

A. Aly, Alan B. Brown, M. Ramadan, 2019, Bioorganic chemistry.

Design and synthesis of new thiazolidinone/uracil derivatives as antiproliferative agents targeting EGFR and/or BRAFV600E

S. Bräse, Akil Ahmad, A. Aly, 2022, Frontiers in Chemistry.

Covalent small-molecule inhibitors of SARS-CoV-2 Mpro: Insights into their design, classification, biological activity, and binding interactions.

Faisal A. Almalki, A. Abdelazeem, A. Gouda, 2024, European journal of medicinal chemistry.

Quinazolin-4-one/3-cyanopyridin-2-one Hybrids as Dual Inhibitors of EGFR and BRAFV600E: Design, Synthesis, and Antiproliferative Activity

Heba A. Hassan, A. Hayallah, L. H. Al-Wahaibi, 2023, Pharmaceuticals.

New pyrrolidine‐carboxamide derivatives as dual antiproliferative EGFR/CDK2 inhibitors

Hazem M. Fathy, B. Youssif, Lihong Wang, 2023, Chemical biology & drug design.

Design and synthesis of new 1,2,4-oxadiazole/quinazoline-4-one hybrids with antiproliferative activity as multitargeted inhibitors

Kholood A. Dahlous, Yaser A. Mostafa, B. Youssif, 2024, Frontiers in Chemistry.

Design and synthesis new indole-based aromatase/iNOS inhibitors with apoptotic antiproliferative activity

L. H. Al-Wahaibi, M. Abdelrahman, Martha M. Morcoss, 2024, Frontiers in chemistry.

Design, synthesis, apoptotic, and antiproliferative effects of 5-chloro-3- (2-methoxyvinyl)-indole-2-carboxamides and pyrido[3,4-b]indol-1-ones as potent EGFRWT/EGFRT790M inhibitors

Xuyuan Gu, L. H. Al-Wahaibi, M. Abdelrahman, 2023, Journal of enzyme inhibition and medicinal chemistry.

Design, synthesis, and antiproliferative activity of new indole/1,2,4-triazole/chalcone hybrids as EGFR and/or c-MET inhibitors.

H. Gomaa, A. Hayallah, Dalia Abdelhamid, 2024, Archiv der Pharmazie.