Radhia Benmohamed

Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic properties.

R. Morimoto, D. Kirsch, R. Silverman, 2014, Bioorganic & medicinal chemistry letters.

Correction to "Chiral Cyclohexane 1,3-Diones as Inhibitors of Mutant SOD1-Dependent Protein Aggregation for the Treatment of ALS".

Wei Zhang, R. Ferrante, R. Morimoto, 2017, ACS medicinal chemistry letters.

Substituted pyrazolones require N2 hydrogen bond donating ability to protect against cytotoxicity from protein aggregation of mutant superoxide dismutase 1.

D. Kirsch, R. Silverman, P. Trippier, 2012, Bioorganic & medicinal chemistry letters.

Chiral cyclohexane 1,3-diones as inhibitors of mutant SOD1-dependent protein aggregation for the treatment of ALS.

R. Ferrante, R. Morimoto, Jinho Kim, 2012, ACS medicinal chemistry letters.

ADME-guided design and synthesis of aryloxanyl pyrazolone derivatives to block mutant superoxide dismutase 1 (SOD1) cytotoxicity and protein aggregation: potential application for the treatment of amyotrophic lateral sclerosis.

R. Ferrante, R. Morimoto, Jinho Kim, 2012, Journal of medicinal chemistry.

Cyclohexane 1,3-diones and their inhibition of mutant SOD1-dependent protein aggregation and toxicity in PC12 cells.

R. Ferrante, R. Morimoto, D. Kirsch, 2012, Bioorganic & medicinal chemistry.

Pyrimidine-2,4,6-trione derivatives and their inhibition of mutant SOD1-dependent protein aggregation. Toward a treatment for amyotrophic lateral sclerosis.

R. Ferrante, R. Morimoto, Jinho Kim, 2011, Journal of medicinal chemistry.

Arylazanylpyrazolone derivatives as inhibitors of mutant superoxide dismutase 1 dependent protein aggregation for the treatment of amyotrophic lateral sclerosis.

R. Morimoto, D. Kirsch, R. Silverman, 2013, Journal of medicinal chemistry.

Identification of compounds protective against G93A-SOD1 toxicity for the treatment of amyotrophic lateral sclerosis

R. Ferrante, R. Morimoto, Jinho Kim, 2011, Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases.

Identifi cation of compounds protective against G 93 A-SOD 1 toxicity for the treatment of amyotrophic lateral sclerosis

R. Ferrante, R. Morimoto, Jinho Kim, 2010 .

Arylsulfanyl pyrazolones block mutant SOD1-G93A aggregation. Potential application for the treatment of amyotrophic lateral sclerosis.

R. Ferrante, R. Morimoto, D. Kirsch, 2011, Bioorganic & medicinal chemistry.

Proteasome Activation is a Mechanism for Pyrazolone Small Molecules Displaying Therapeutic Potential in Amyotrophic Lateral Sclerosis

R. Morimoto, D. Kirsch, R. Silverman, 2014, ACS chemical neuroscience.