D. R. Spring

发表

The effect of humidity on the ozonolysis of unsaturated compounds in aerosol particles.

Stephen J. Fuller, F. Pope, D. Spring, 2012, Physical chemistry chemical physics : PCCP.

Importance of relative humidity in the oxidative ageing of organic aerosols: case study of the ozonolysis of maleic acid aerosol

F. Pope, D. Spring, P. Gallimore, 2011 .

A two-component 'double-click' approach to peptide stapling

D. Spring, W. R. Galloway, Y. H. Lau, 2015, Nature Protocols.

Microscopy and chemical analyses reveal flavone-based woolly fibres extrude from micron-sized holes in glandular trichomes of Dionysia tapetodes

R. Wightman, Karin H. Müller, Matthieu Bourdon, 2021, BMC plant biology.

Coumarin-derived transformable fluorescent sensor for Zn2+.

D. Spring, Zhaochao Xu, Jie Pan, 2012, Chemical communications.

Engineering of new prodigiosin-based biosensors of Serratia for facile detection of short-chain N-acyl homoserine lactone quorum-sensing molecules.

D. Spring, G. Salmond, Timothy M. Carlton, 2010, Environmental microbiology reports.

All-in-one disulfide bridging enables the generation of antibody conjugates with modular cargo loading

Stephen J. Walsh, J. Carroll, D. Spring, 2022, Chemical science.

General dual functionalisation of biomacromolecules via a cysteine bridging strategy.

Stephen J. Walsh, J. Carroll, D. Spring, 2020, Organic & biomolecular chemistry.

Efficient and selective antibody modification with functionalised divinyltriazines.

Stephen J. Walsh, D. Spring, N. Robertson, 2020, Organic & biomolecular chemistry.

Direct Synthesis of N-Functionalized Dipropargylamine Linkers as Models for Use in Peptide Stapling

D. Spring, H. Sore, Andrea Renzetti, 2019, Synlett.

Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides.

D. Spring, G. McKenzie, Peterson de Andrade, 2015, Angewandte Chemie.

A general approach for the site-selective modification of native proteins, enabling the generation of stable and functional antibody–drug conjugates† †Dedicated to Professor Jack Baldwin on the occasion of his 80th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c

Stephen J. Walsh, J. Carroll, D. Spring, 2018, Chemical science.

Multiple‐parameter Optimization in Drug Discovery: Example of the 5‐HT1B GPCR

R. Glen, W. R. Galloway, D. R. Spring, 2016, Molecular informatics.

A dual-enzyme cleavable linker for antibody-drug conjugates.

Stephen J. Walsh, J. Carroll, D. Spring, 2021, Chemical communications.

Cleavable linkers in antibody-drug conjugates.

D. Spring, Albert Isidro-Llobet, Jonathan D Bargh, 2019, Chemical Society reviews.

A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells.

D. Spring, Zhaochao Xu, Jingnan Cui, 2013, Organic letters.

2-Heptyl-4-Quinolone, a Precursor of the Pseudomonas Quinolone Signal Molecule, Modulates Swarming Motility in Pseudomonas aeruginosa

D. Spring, M. Welch, G. O’Toole, 2011, Journal of bacteriology.

Stereocontrolled semi-syntheses of deguelin and tephrosin† †Electronic supplementary information (ESI) available: 1H and 13C NMR spectra. See DOI: 10.1039/c6ob02659a Click here for additional data file.

D. Spring, D. Russell, H. Sore, 2017, Organic and biomolecular chemistry.

Stereocontrolled Semisyntheses of Elliptone and 12aβ-Hydroxyelliptone.

D. Spring, D. Russell, H. Sore, 2017, Journal of natural products.

Synthesis and Reactivity of a Bis-Strained Alkyne Derived from 1,1′-Biphenyl-2,2′,6,6′-tetrol

D. Spring, N. Robertson, M. Wills, 2019, ACS omega.

Identification of new quorum sensing autoinducer binding partners in Pseudomonas aeruginosa using photoaffinity probes† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc01270e Click here for additional data file.

D. Spring, M. Welch, B. Florea, 2017, Chemical science.

Small molecules in biology.

D. Spring, A. Hamilton, A. Tavassoli, 2011, Chemical Society reviews.

Highly reactive bis-cyclooctyne-modified diarylethene for SPAAC-mediated cross-linking.

D. Spring, A. Ulrich, S. Afonin, 2018, Organic & biomolecular chemistry.

The oxidation of organocuprates--an offbeat strategy for synthesis.

D. Spring, D. Surry, D. R. Spring, 2006, Chemical Society reviews.

2-Aminopyridine Analogs Inhibit Both Enzymes of the Glyoxylate Shunt in Pseudomonas aeruginosa

D. Spring, M. Welch, P. Tammela, 2020, International journal of molecular sciences.

Divergent synthesis of biflavonoids yields novel inhibitors of the aggregation of amyloid β (1-42).

D. Spring, F. Hollfelder, W. R. Galloway, 2017, Organic & biomolecular chemistry.

Palladium-catalysed cross-coupling of organosilicon reagents.

D. Spring, W. R. Galloway, H. Sore, 2012, Chemical Society reviews.

Vinyldisiloxanes: their synthesis, cross coupling and applications.

D. Spring, Luca Laraia, W. R. Galloway, 2011, Organic & biomolecular chemistry.

Fluoride-free cross coupling using vinyldisiloxanes.

D. Spring, S. Macdonald, D. Fox, 2009, Organic & biomolecular chemistry.

The role of chemical synthesis in developing RiPP antibiotics.

D. Spring, D. R. Spring, S. Rowe, 2021, Chemical Society reviews.

Second-generation CK2α inhibitors targeting the αD pocket† †Electronic supplementary information (ESI) available: All experimental details, crystallographic data collection and refinement statistics, details of chemical synthesis, additional figures and tables. See DOI: 10.1039/c7sc05122k

D. Spring, P. Brear, M. Rossmann, 2018, Chemical science.

Skeletal diversity construction via a branching synthetic strategy.

Suzanne Fergus, Andreas Bender, Warren R. J. D. Galloway, 2006, Chemical communications.

Diversity‐Oriented Synthesis: Developing New Chemical Tools to Probe and Modulate Biological Systems

D. Spring, Luca Laraia, W. R. Galloway, 2014 .

Diversity-Oriented Synthesis: A Spectrum of Approaches and Results

Andreas Bender, David R. Spring, Richard J. Spandl, 2008 .

Diversity-oriented synthesis of macrocyclic

Andreas Bender, Warren R. J. D. Galloway, David R. Spring, 2011 .

LGR5 targeting molecules as therapeutic agents for multiple cancer types

Stephen J. Walsh, J. Brenton, D. Spring, 2022, bioRxiv.

Non-internalising antibody-drug conjugates.

D. Spring, Jonathan D Bargh, D. R. Spring, 2022, Chemical Society reviews.

Photocatalytic methods for amino acid modification.

Stephen J. Walsh, D. Spring, T. A. King, 2020, Chemical Society reviews.

Studies on the Biomimetic Synthesis of the Manzamine Alkaloids

D. Spring, T. Claridge, J. Baldwin, 1999 .

The Discovery of Antibacterial Agents Using Diversity‐Oriented Synthesis

A. Bender, M. Welch, W. R. Galloway, 2009 .

Structure-Activity Analysis of the Pseudomonas Quinolone Signal Molecule

D. Spring, M. Welch, W. R. Galloway, 2010, Journal of bacteriology.

Enantioselective Synthesis of Chromanones via a Peptidic Phosphane Catalyzed Rauhut-Currier Reaction.

D. Spring, André Grossmann, R. Scanes, 2015, Organic letters.

Water-soluble, stable and azide-reactive strained dialkynes for biocompatible double strain-promoted click chemistry.

D. Spring, L. Itzhaki, M. Hyvönen, 2019, Organic & biomolecular chemistry.

Oxidation of Organocopper Compounds

D. Spring, S. J. Aves, D. R. Spring, 2011 .

Development of a Novel Cell-Permeable Protein–Protein Interaction Inhibitor for the Polo-box Domain of Polo-like Kinase 1

D. Spring, G. McKenzie, A. Venkitaraman, 2019, ACS omega.

Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

David R Spring, Warren R J D Galloway, D. Spring, 2010, Nature communications.

Arene C-H functionalisation using a removable/modifiable or a traceless directing group strategy.

D. Spring, Fengzhi Zhang, D. R. Spring, 2014, Chemical Society reviews.

Concise synthesis of rare pyrido[1,2-a]pyrimidin-2-ones and related nitrogen-rich bicyclic scaffolds with a ring-junction nitrogen.

D. Spring, W. R. Galloway, S. Bartlett, 2016, Organic and biomolecular chemistry.

Studies towards the synthesis of indolizin-5(3H)-one derivatives and related 6,5-azabicyclic scaffolds by ring-closing metathesis.

Jamie E. Stokes, D. Spring, W. R. Galloway, 2015, Bioorganic & medicinal chemistry.

Combating multidrug-resistant bacteria: current strategies for the discovery of novel antibacterials.

Kieron M. G. O'Connell, D. Spring, M. Welch, 2013, Angewandte Chemie.

The discovery of antibacterial agents using diversity-oriented synthesis.

Andreas Bender, David R Spring, Martin Welch, 2009, Chemical communications.

An expedient strategy for the diversity-oriented synthesis of macrocyclic compounds with natural product-like characteristics

Warren R. J. D. Galloway, David R. Spring, Cornelius J. O'Connor, 2016 .

Partially Saturated Bicyclic Heteroaromatics as an sp3‐Enriched Fragment Collection

Warren R. J. D. Galloway, David R. Spring, D. Spring, 2016, Angewandte Chemie.

Drug discovery: A question of library design

Warren R. J. D. Galloway, David R. Spring, Philip J. Hajduk, 2011, Nature.

Synthesis of medium-ring and iodinated biaryl compounds by organocuprate oxidation.

D. Spring, Vilius Franckevičius, S. Macdonald, 2005, Angewandte Chemie.

Protein modification via alkyne hydrosilylation using a substoichiometric amount of ruthenium(ii) catalyst† †Dedicated to Professor Stuart L. Schreiber on the occasion of his 60th birthday. ‡ ‡Electronic supplementary information (ESI) available. See DOI: 10.1039/c6sc05313k Click here for additional

Stephen J. Walsh, David R Spring, Martin Welch, 2017, Chemical science.

Two-directional synthesis as a tool for diversity-oriented synthesis: Synthesis of alkaloid scaffolds

David R Spring, Kieron M. G. O'Connell, Warren R J D Galloway, 2012, Beilstein journal of organic chemistry.

Cycloaddition Strategies for the Synthesis of Diverse Heterocyclic Spirocycles for Fragment‐Based Drug Discovery

D. Spring, T. A. King, H. Stewart, 2019, European journal of organic chemistry.

Synthesis of Unprecedented Scaffold Diversity

D. Spring, W. R. Galloway, Albert Isidro-Llobet, 2009 .

Synthesis of unprecedented scaffold diversity.

David R Spring, Warren R J D Galloway, D. Spring, 2009, Angewandte Chemie.

Chemical genetics to chemical genomics: small molecules offer big insights.

David R Spring, D. Spring, D. R. Spring, 2005, Chemical Society reviews.

Diversity-oriented synthesis: producing chemical tools for dissecting biology.

David R Spring, D. Spring, Henning S. g. Beckmann, 2012, Chemical Society reviews.

Targeting a Novel KRAS Binding Site: Application of One-Component Stapling of Small (5-6-mer) Peptides.

D. Spring, J. Nissink, Andrew P Thomas, 2021, Journal of medicinal chemistry.

Diversity-oriented synthesis of bicyclic and tricyclic alkaloids.

Kieron M. G. O'Connell, D. Spring, W. R. Galloway, 2010, Chemical communications.

Identification of an anti-MRSA dihydrofolate reductase inhibitor from a diversity-oriented synthesis.

David R Spring, Martin Welch, Warren R J D Galloway, 2008, Chemical communications.

The Basics of Diversity‐Oriented Synthesis

Warren R. J. D. Galloway, David R. Spring, Kieron M. G. O'Connell, 2013 .

Diversity-oriented synthesis.

David R Spring, Kieron M. G. O'Connell, D. Spring, 2009, Chemical record.

Combating Multidrug-Resistant Bacteria: Current Strategies for the Discovery of Novel Antibacterials

David R. Spring, Martin Welch, Kieron M. G. O'Connell, 2013 .

Rapid and robust cysteine bioconjugation with vinylheteroarenes†

Stephen J. Walsh, J. Carroll, D. Spring, 2021, Chemical science.

A strategy for the diversity-oriented synthesis of macrocyclic scaffolds using multidimensional coupling.

David R Spring, Yaw Sing Tan, Feilin Nie, 2013, Nature chemistry.

Investigations into the Manzamine Alkaloid Biosynthetic Hypothesis.

D. Spring, I. Mutton, T. Claridge, 1998, Angewandte Chemie.

A novel complexity-to-diversity strategy for the diversity-oriented synthesis of structurally diverse and complex macrocycles from quinine.

D. Spring, J J Ciardiello, H L Stewart, 2017, Bioorganic & medicinal chemistry.

The multifaceted nature of antimicrobial peptides: current synthetic chemistry approaches and future directions

D. Spring, B. Gan, Josephine Gaynord, 2021, Chemical Society reviews.

A one-bead, one-stock solution approach to chemical genetics: part 2.

P. Clemons, D. Spring, M. Foley, 2001, Chemistry & biology.

A diversity-oriented synthesis strategy enabling the combinatorial-type variation of macrocyclic peptidomimetic scaffolds

D. Spring, Y. S. Tan, W. R. Galloway, 2015, Organic & biomolecular chemistry.

Synthesis of Structurally Diverse N‐Substituted Quaternary‐Carbon‐Containing Small Molecules from α,α‐Disubstituted Propargyl Amino Esters

Andreas Bender, David R Spring, Leen Kalash, 2018, Chemistry.

Synthesis and utilization of functionalized polystyrene resins

D. Spring, M. Ladlow, G. Thomas, 2005 .

Divergent and concise total syntheses of dihydrochalcones and 5-deoxyflavones recently isolated from Tacca species and Mimosa diplotricha

D. Spring, W. R. Galloway, T. H. Sum, 2015 .

Synthesis and biological profiling of tellimagrandin I and analogues reveals that the medium ring can significantly modulate biological activity.

D. Spring, Y. S. Tan, A. Venkitaraman, 2012, Organic & biomolecular chemistry.

Synthesis of Biaryl-ContainingMedium-Ring Systems by Organocuprate Oxidation: Applications inthe Total Synthesis of Ellagitannin Natural Products

W. R. Galloway, R. J. Spandl, G. Thomas, 2009 .

Total synthesis of sanguiin H-5.

D. Spring, R. J. Spandl, D. Surry, 2008, Organic letters.

Aryl—Aryl Coupling via Directed Lithiation and Oxidation.

S. Macdonald, D. Fox, D. Surry, 2005 .

Diversity-oriented synthesis; a challenge for synthetic chemists.

David R Spring, D. Spring, D. R. Spring, 2003, Organic & biomolecular chemistry.

Towards Diversity-Oriented, Stereoselective Syntheses of Biaryl- or Bis(aryl)metal-Containing Medium Rings

Stuart L. Schreiber, David R. Spring, Shyam Krishnan, 2000 .

High throughput ‘catch-and-release’ synthesis within spatially discrete gel arrays

D. Spring, H. Sore, David Norton, 2010 .

C(sp3)-H arylation to construct all-syn cyclobutane-based heterobicyclic systems: a novel fragment collection.

D. Spring, S. L. Kidd, T. A. King, 2020, Chemical communications.

Exploiting domino enyne metathesis mechanisms for skeletal diversity generation.

David R Spring, D. Spring, Richard J Spandl, 2008, Chemical communications.

Copper catalyzed oxidation of organozinc halides.

D. Fox, D. R. Spring, Xianbin Su, 2006, Chemical communications.

Aryl-aryl coupling via directed lithiation and oxidation.

S. Macdonald, D. Fox, D. Surry, 2005, Chemical communications.

Fluorescent chemosensors for Zn(2+).

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010, Chemical Society reviews.

(Z)-Selective Takai olefination of salicylaldehydes

D. Spring, J. Goodman, W. R. Galloway, 2017, Beilstein journal of organic chemistry.

Diversity-oriented synthesis of heterocycles and macrocycles by controlled reactions of oxetanes with α-iminocarbenes

D. Spring, Alejandro Guarnieri-Ibáñez, Florian Medina, 2017, Chemical science.

Complete functionalisation of small and large diameter bromopolystyrene beads; applications for solid-supported reagents, scavengers and diversity-oriented synthesis.

David R Spring, D. Spring, M. Ladlow, 2004, Organic & biomolecular chemistry.

Divergent Synthesis of Quinolone Natural Products from Pseudonocardia sp. CL38489

D. Spring, J. Hodgkinson, L. Carro, 2016, European journal of organic chemistry.

Zn2+-triggered amide tautomerization produces a highly Zn2+-selective, cell-permeable, and ratiometric fluorescent sensor.

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010, Journal of the American Chemical Society.

Strategies for the Diversity-Oriented Synthesis of Macrocycles.

D. Spring, T. A. King, Kim T Mortensen, 2019, Chemical reviews.

Induction-driven stabilization of the anion-π interaction in electron-rich aromatics as the key to fluoride inclusion in imidazolium-cage receptors.

Kwang S. Kim, Kwang Soo Kim, D. Spring, 2011, Chemistry.

Peptide stapling techniques based on different macrocyclisation chemistries.

D. Spring, Peterson de Andrade, Y. H. Lau, 2015, Chemical Society reviews.

Fluorescent sensing and discrimination of ATP and ADP based on a unique sandwich assembly of pyrene-adenine-pyrene.

D. Spring, Juyoung Yoon, Zhaochao Xu, 2011, Chemistry, an Asian journal.

Ratiometric fluorescent and colorimetric sensors for Cu2+ based on 4,5-disubstituted-1,8-naphthalimide and sensing cyanide via Cu2+ displacement approach

David R. Spring, Jie Pan, Juyoung Yoon, 2010 .

A selective and ratiometric Cu2+ fluorescent probe based on naphthalimide excimer-monomer switching.

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010, Chemical communications.

Discovery of a highly selective turn-on fluorescent probe for Ag+.

D. Spring, Juyoung Yoon, Zhaochao Xu, 2010, The Analyst.

Aryl-aryl bond formation by the fluoride-free cross-coupling of aryldisiloxanes with aryl bromides.

Kieron M. G. O'Connell, D. Spring, D. G. Hulcoop, 2011, Chemistry.

Two‐Component Stapling of Biologically Active and Conformationally Constrained Peptides: Past, Present, and Future

D. Spring, M. Hyvönen, N. Robertson, 2018, Advanced Therapeutics.

Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions

D. Spring, N. Robertson, D. R. Spring, 2018, Molecules.

Rational methods for the selection of diverse screening compounds.

David R Spring, David J Huggins, Ashok R Venkitaraman, 2011, ACS chemical biology.

Loving the poison: the methylcitrate cycle and bacterial pathogenesis.

D. Spring, M. Welch, Rafael Silva-Rocha, 2018, Microbiology.

Quorum sensing in Gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways.

James T Hodgkinson, David R Spring, Martin Welch, 2011, Chemical reviews.

Toxicity of six plant extracts and two pyridone alkaloids from Ricinus communis against the malaria vector Anopheles gambiae

D. Spring, D. Masiga, H. Alborn, 2014, Parasites & Vectors.