L. Schäkel

发表

Small-Molecule Thioesters as SARS-CoV-2 Main Protease Inhibitors: Enzyme Inhibition, Structure–Activity Relationships, Antiviral Activity, and X-ray Structure Determination

Yechun Xu, A. Poso, M. Gütschow, 2022, Journal of medicinal chemistry.

3CL Protease Inhibitors with an Electrophilic Arylketone Moiety as Anti-SARS-CoV-2 Agents.

C. Müller, M. Gütschow, A. Kawaguchi, 2021, Journal of medicinal chemistry.

Sulfated Polysaccharides from Macroalgae Are Potent Dual Inhibitors of Human ATP-Hydrolyzing Ectonucleotidases NPP1 and CD39

C. Müller, J. Sévigny, J. Pelletier, 2021, Marine drugs.

Protein kinase inhibitor ceritinib blocks ectonucleotidase CD39 – a promising target for cancer immunotherapy

J. Sévigny, J. Pelletier, E. Tolosa, 2022, Journal for ImmunoTherapy of Cancer.

Fluorescent Probes for Ecto-5'-nucleotidase (CD73).

C. Müller, G. Yegutkin, I. Schmidt-Wolf, 2020, ACS medicinal chemistry letters.

Discovery and Crystallographic Studies of Trisubstituted Piperazine Derivatives as Non-Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity and Low Toxicity

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Targeting the Main Protease of SARS‐CoV‐2: From the Establishment of High Throughput Screening to the Design of Tailored Inhibitors

A. Schiedel, C. Müller, M. Gütschow, 2021, Angewandte Chemie.

2‐Substituted thienotetrahydropyridine derivatives: Allosteric ectonucleotidase inhibitors

M. Gütschow, J. Sévigny, J. Pelletier, 2021, Archiv der Pharmazie.

Development of Anthraquinone Derivatives as Ectonucleoside Triphosphate Diphosphohydrolase (NTPDase) Inhibitors With Selectivity for NTPDase2 and NTPDase3

C. Müller, J. Sévigny, J. Pelletier, 2020, Frontiers in Pharmacology.

Synthesis and structure-activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39.

J. Sévigny, J. Pelletier, Thanigaimalai Pillaiyar, 2023, Bioorganic chemistry.

Nucleotide Analog ARL67156 as a Lead Structure for the Development of CD39 and Dual CD39/CD73 Ectonucleotidase Inhibitors

C. Müller, J. Sévigny, J. Pelletier, 2020, Frontiers in Pharmacology.

Discovery and Crystallographic Studies of Nonpeptidic Piperazine Derivatives as Covalent SARS-CoV-2 Main Protease Inhibitors

Dongwei Kang, P. Zhan, Xinyong Liu, 2022, Journal of medicinal chemistry.

Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1) – a promising target for the immunotherapy of cancer

J. Pelletier, G. Bendas, O. Vanakker, 2023, Frontiers in immunology.