O. Caamaño

发表

Synthesis and pharmacological evaluation of novel 1,3,8- and 1,3,7,8-substituted xanthines as adenosine receptor antagonists.

X. García‐Mera, M. Loza, O. Caamaño, 2010, Bioorganic & medicinal chemistry.

Synthesis of novel 1-alkyl-8-substituted-3-(3-methoxypropyl) xanthines as putative A(2B) receptor antagonists.

O. Caamaño, J. Brea, M. Cadavid, 2009, Bioorganic & medicinal chemistry.

Synthesis and evaluation of adenosine antagonist activity of a series of [1,2,4]triazolo[1,5-c]quinazolines.

J. Brea, O. Caamaño, F. Fernández, 2007, Chemical & pharmaceutical bulletin.

Polymer‐Supported 1,5,7‐Triazabicyclo[4.4.0]dec‐5‐ene as Polyvalent Ligands in the Copper‐Catalyzed Huisgen 1,3‐Dipolar Cycloaddition

E. Sotelo, Alberto Coelho, O. Caamaño, 2010 .

3,4-Dihydropyrimidin-2(1H)-ones as Antagonists of the Human A2B Adenosine Receptor: Optimization, Structure-Activity Relationship Studies, and Enantiospecific Recognition.

J. Åqvist, X. García‐Mera, J. Azuaje, 2020, Journal of medicinal chemistry.

A click chemistry approach to the synthesis of 3′-deoxy-2′-substituted carbanucleoside precursors

X. García‐Mera, Marcos D. García, O. Caamaño, 2015 .

Synthesis of 4-substituted-1,2,3-triazole carbanucleoside analogues of ribavirin via click chemistry.

E. De Clercq, Marcos D. García, F. Fernández, 2007, Organic & biomolecular chemistry.

Novel l-prolyl-l-leucylglycinamide (PLG) tripeptidomimetics based on a 2-azanorbornane scaffold as positive allosteric modulators of the D2R.

X. García‐Mera, J. Rodríguez-Borges, C. Sousa, 2016, Organic & biomolecular chemistry.

Synthesis and pharmacological evaluation of novel 1- and 8-substituted-3-furfuryl xanthines as adenosine receptor antagonists.

X. García‐Mera, M. Loza, J. Brea, 2009, Bioorganic & medicinal chemistry.

Advances towards the synthesis and characterization of five-membered cyclic alcohols and ketones

X. García‐Mera, Marcos D. García, O. Caamaño, 2017 .

Synthesis of new 6-substituted purinyl-5′-nor-1′-homocarbanucleosides based on indanol

X. García‐Mera, E. D. Clercq, F. Fernández, 2004 .

Carbocyclic analogues of nucleosides from bis-(Hydroxymethyl)-cyclopentane: synthesis, antiviral and cytostatic activities of adenosine, inosine and uridine analogues.

E. De Clercq, O. Caamaño, J. Balzarini, 2003, Chemical & pharmaceutical bulletin.

SYNTHESIS, ANTIVIRAL AND CYTOSTATIC ACTIVITIES, OF CARBOCYCLIC NUCLEOSIDES INCORPORATING A MODIFIED CYCLOPENTANE RING. IV. ADENOSINE AND URIDINE ANALOGUES

E. De Clercq, J. Balzarini, F. Fernández, 2002, Nucleosides, nucleotides & nucleic acids.

Synthesis and antiviral activity of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 3: Adenosine and uridine analogues.

E. De Clercq, X. García‐Mera, J. Balzarini, 1999, Nucleosides & nucleotides.

An efficient and recyclable 3D printed α-Al2O3 catalyst for the multicomponent assembly of bioactive heterocycles

J. Azuaje, E. Sotelo, Alberto Coelho, 2017 .

Synthesis of (1R,cis)-3-aminomethyl-1,2,2-trimethylcyclopentane-methanol : two approaches using α-camphidone

G. Gómez, F. Fernández, O. Caamaño, 1994 .

Pyrazin-2(1H)-ones as a novel class of selective A3 adenosine receptor antagonists.

J. Azuaje, E. Sotelo, H. Gutiérrez‐de‐Terán, 2015, Future medicinal chemistry.

Regioselectivity in the formation of norbornene-fused pyrazoles: Preparation of 1-substituted derivatives of 4,5,6,7-tetrahydro-1H-4,7- methanoindazole

J. Elguero, I. Alkorta, Marcos D. García, 2006 .

Trifluorinated Pyrimidine-Based A2B Antagonists: Optimization and Evidences of Stereospecific Recognition.

X. García‐Mera, J. Azuaje, M. Loza, 2019, Journal of medicinal chemistry.

Synthesis by microwave-assisted 1,3-dipolar cycloaddition of 1,2,3-triazole 1'-homo-3'-isoazanucleosides and evaluation of their anticancer activity.

X. García‐Mera, M. Loza, J. Brea, 2015, European journal of medicinal chemistry.

Using entropy of drug and protein graphs to predict FDA drug-target network: theoretic-experimental study of MAO inhibitors and hemoglobin peptides from Fasciola hepatica.

Humberto González-Díaz, Florencio M Ubeira, Xerardo García-Mera, 2011, European journal of medicinal chemistry.

Chiral sulfinic acids: Synthesis of sodium (1S,2S,5R)-2-isopropyl-5-mmethylcyclohexanesulfinate by a novel route

F. Fernández, O. Caamaño, J. Blanco, 1995 .

Copper-catalyzed Huisgen 1,3-dipolar cycloaddition under oxidative conditions: polymer-assisted assembly of 4-acyl-1-substituted-1,2,3-triazoles.

J. Azuaje, E. Sotelo, Alberto Coelho, 2013, The Journal of organic chemistry.

Synthetic approaches to (1S,3R)-3-aminomethyl-2,2,3-trimethylcyclopentylmethanol and (1S,3R)-3-amino-2,2,3-trimethylcyclopentylmethanol from (+)-camphoric acid

G. Gómez, O. Caamaño, F. Fernández, 1998 .

Design, Synthesis, and Evaluation of Antineoplastic Activity of Novel Carbocyclic Nucleosides

Aliuska M. Helguera , J. E. Rodríguez‐Borges, Olga Caamaño, 2010, Molecular informatics.

Syntheses of Chiral Menthyl and Neomenthyl Sulfides, sulfoxides and sulfones

F. Fernández, O. Caamaño, I. Nieto, 1995 .

Synthesis of enantiopure cyclobutane amino acids and amino alcohols

F. Fernández, O. Caamaño, C. López, 2005 .

SYNTHESIS OF (1R,3S)-3-AMINO-1,2,2-TRIMETHYLCYCLOPENTYLMETHANOL

X. García‐Mera, F. Fernández, O. Caamaño, 1998 .

A route to selective functionalization of polyhydroxypyrrolidines

X. García‐Mera, J. Rodríguez-Borges, C. Sousa, 2012 .

Synthesis of Chiral Sulfinic Acids: Sodium(1S-exo)-2-Bornanesulfinate

F. Fernández, O. Caamaño, J. Blanco, 1990 .

Synthesis, antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclopentane ring. Part 2: Adenosine and uridine analogues.

E. De Clercq, X. García‐Mera, J. Neyts, 1998, Nucleosides & nucleotides.

Synthesis, Antiviral and Cytostatic Activities of Carbocyclic Nucleosides Incorporating a Modified Cyclopentane Ring. Part 2. Adenosine and Uridine Analogues.

X. García‐Mera, J. Neyts, J. Balzarini, 1998 .

Synthesis and antiviral and cytostatic activities of carbocyclic nucleosides incorporating a modified cyclobutane ring. Part 1: Guanosine analogues.

X. García‐Mera, M J Figueira, J M Blanco, 1999, Archiv der Pharmazie.

Synthetic approaches to (±)-c-4-amino-r-1,c-2,t-3-cyclopentanetrimethanol: a precursor of higher homologues of xylo-carbocyclic nucleosides

X. García‐Mera, O. Caamaño, Marcos D. García, 2002 .

The use of (−)-8-phenylisoneomenthol and (−)-8-phenylmenthol in the enantioselective synthesis of 3-functionalized 2-azabicyclo[2.2.1]heptane derivatives via aza-Diels–Alder reaction

X. García‐Mera, O. Caamaño, J. Rodríguez-Borges, 2006 .

Synthesis of (′)-c-4-amino-r-1,t-2,c-3-cyclopentanetrimethanol and higher homologues of 8-azapurine arabino-carbocyclic nucleosides

M. J. Figueira, F. Fernández, O. Caamaño, 2002 .

Synthesis of two enantiomerically pure precursors of cyclobutane carbocyclic nucleosides

F. Fernández, O. Caamaño, C. López, 2003 .

A useful synthesis of chiral sulfonyl cyanides: (1S,2S,5R)-2-isopropyl-5-methylcyclohexanesulfonyl cyanide

G. Gómez, C. López, F. Fernández, 1992 .

A short, efficient synthesis of the chiral auxiliary (+)-8-phenylneomenthol

X. García‐Mera, J. Rodríguez-Borges, F. Fernández, 2000 .

An Efficient Method for Preparation of Chiral Arylmenthol Glyoxylates

X. García‐Mera, C. López, J. Rodríguez-Borges, 1998 .

Enantioselective synthesis of 3-functionalized 2-azabicyclo[2.2.1]hept-5-enes by hetero Diels-Alder addition to cyclopentadiene

X. García‐Mera, J. Rodríguez-Borges, F. Fernández, 1998 .

A convenient synthesis of new purinyl-homo-carbonucleosides on a cyclopentane ring fused with pyridazine

G. Gómez, X. García‐Mera, Marcos D. García, 2004 .

Synthesis and Biological Evaluationof 6-Substituted Purinylcarbanucleosides with a Cyclopenta[b]thiophene Pseudosugar

X. García‐Mera, J. Balzarini, E. Clercq, 2009 .

A convenient synthesis of new 6-substituted purinylcarbanucleosides on cyclopenta[b]thiophene

Marcos D. García, Paula Abeijón, F. Fernández, 2008 .

Synthesis of novel purinyl-1'-homocarbanucleosides based on a cyclopenta[b]pyrazine system.

X. García‐Mera, J. Rodríguez-Borges, F. Fernández, 2008, Chemical & pharmaceutical bulletin.

Synthesis and Oxidative Cleavage of 1- and 2-Alkyl Derivatives of (exo,exo)-5,6-Dihydroxy-4,5,6,7-tetrahydro-4,7-methanoindazoles

G. Gómez, Marcos D. García, M. J. Figueira, 2003 .

Synthesis of methyl (±)-3,5-bis(substitutedmethyl)pyrrolidine-2-carboxylates: a convenient approach to proline-mimetics

X. García‐Mera, J. Rodríguez-Borges, F. Fernández, 2010 .

Brain-inspired cheminformatics of drug-target brain interactome, synthesis, and assay of TVP1022 derivatives

Humberto González-Díaz, Xerardo García-Mera, Nerea Alonso, 2016, Neuropharmacology.

Prediction of Multi-Target Networks of Neuroprotective Compounds with Entropy Indices and Synthesis, Assay, and Theoretical Study of New Asymmetric 1,2-Rasagiline Carbamates

Humberto González-Díaz, Francisco J. Prado-Prado, Xerardo García-Mera, 2014, International journal of molecular sciences.

Model for high-throughput screening of multitarget drugs in chemical neurosciences: synthesis, assay, and theoretic study of rasagiline carbamates.

Feng Luan, Humberto González-Díaz, Xerardo García-Mera, 2013, ACS chemical neuroscience.

TOPS-MODE model of multiplexing neuroprotective effects of drugs and experimental-theoretic study of new 1,3-rasagiline derivatives potentially useful in neurodegenerative diseases.

Feng Luan, M Natália D S Cordeiro, Humberto González-Díaz, 2013, Bioorganic & medicinal chemistry.

Synthesis and pharmacological evaluation of novel substituted 9-deazaxanthines as A2B receptor antagonists.

X. García‐Mera, M. Loza, J. Brea, 2010, European journal of medicinal chemistry.

Synthesis and neuroleptic activity of some trans-(2-aminomethyl)-cyclopentyl aryl ketones

E. Uriarte, J. Calleja, F. Orallo, 1987 .

A Nitrogen-Walk Approach to Explore Bioisosteric Replacements in a Series of Potent A2B Adenosine Receptor Antagonists.

X. García‐Mera, M. Loza, J. Brea, 2020, Journal of medicinal chemistry.

Semi‐rigid Models of Butyrophenones: trans‐Phenyl‐[2‐(1‐piperidinylmethyl)cyclopentyl]methanone

E. Uriarte, F. Fernández, O. Caamaño, 1987 .

Synthesis and allosteric modulation of the dopamine receptor by peptide analogs of L-prolyl-L-leucyl-glycinamide (PLG) modified in the L-proline or L-proline and L-leucine scaffolds.

X. García‐Mera, J. Brea, M. Cadavid, 2013, European journal of medicinal chemistry.

Pyrimidine derivatives as potent and selective A3 adenosine receptor antagonists.

X. García‐Mera, M. Loza, E. Sotelo, 2011, Journal of medicinal chemistry.

Synthesis and Evaluation of Adenosine Antagonist Activity of a Series of [ 1 , 2 , 4 ] Triazolo [ 1 , 5c ] quinazolines

J. Brea, F. Fernández, O. Caamaño, 2007 .

MIND-BEST: Web server for drugs and target discovery; design, synthesis, and assay of MAO-B inhibitors and theoretical-experimental study of G3PDH protein from Trichomonas gallinae.

C. Munteanu, F. Prado-Prado, H. González-Díaz, 2011, Journal of proteome research.

Effect of Nitrogen Atom Substitution in A3 Adenosine Receptor Binding: N-(4,6-Diarylpyridin-2-yl)acetamides as Potent and Selective Antagonists.

Hugo Gutiérrez-de-Terán, José Brea, Willem Jespers, 2017, Journal of medicinal chemistry.

1,3-dialkyl-8-N-substituted benzyloxycarbonylamino-9-deazaxanthines as potent adenosine receptor ligands: Design, synthesis, structure-affinity and structure-selectivity relationships.

X. García‐Mera, J. Brea, O. Nicolotti, 2009, Bioorganic & medicinal chemistry.