Tuba Cuez

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Activation of MEK1/ERK1/2/iNOS/sGC/PKG pathway associated with peroxynitrite formation contributes to hypotension and vascular hyporeactivity in endotoxemic rats.

B. Tunctan, Seyhan Sahan-Firat, B. Korkmaz, 2011, Nitric oxide : biology and chemistry.

Piroxicam reverses endotoxin-induced hypotension in rats: contribution of vasoactive eicosanoids and nitric oxide.

B. Tunctan, K. Malik, Seyhan Sahan-Firat, 2011, Basic & clinical pharmacology & toxicology.

Contribution of RhoA/Rho-kinase/MEK1/ERK1/2/iNOS pathway to ischemia/reperfusion-induced oxidative/nitrosative stress and inflammation leading to distant and target organ injury in rats.

Ozden Vezir, N. Sucu, B. Tunctan, 2014, European journal of pharmacology.

5,14-HEDGE, a 20-HETE mimetic, reverses hypotension and improves survival in a rodent model of septic shock: contribution of soluble epoxide hydrolase, CYP2C23, MEK1/ERK1/2/IKKβ/IκB-α/NF-κB pathway, and proinflammatory cytokine formation.

J. Falck, B. Tunctan, K. Malik, 2013, Prostaglandins & other lipid mediators.

Contribution of vasoactive eicosanoids and nitric oxide production to the effect of selective cyclooxygenase-2 inhibitor, NS-398, on endotoxin-induced hypotension in rats.

J. Falck, B. Tunctan, K. Malik, 2010, Basic & clinical pharmacology & toxicology.

A synthetic analogue of 20-HETE, 5,14-HEDGE, reverses endotoxin-induced hypotension via increased 20-HETE levels associated with decreased iNOS protein expression and vasodilator prostanoid production in rats.

J. Falck, B. Tunctan, K. Malik, 2009, Basic & clinical pharmacology & toxicology.

Contribution of iNOS/sGC/PKG pathway, COX-2, CYP4A1, and gp91(phox) to the protective effect of 5,14-HEDGE, a 20-HETE mimetic, against vasodilation, hypotension, tachycardia, and inflammation in a rat model of septic shock.

J. Falck, B. Tunctan, K. Malik, 2013, Nitric oxide : biology and chemistry.

Activation of MEK1/ERK1/2/iNOS/sGC/PKG pathway associated with peroxynitrite formation contributes to hypotension and vascular hyporeactivity in endotoxemic rats.

B. Tunctan, Seyhan Sahan-Firat, B. Korkmaz, 2011, Nitric oxide : biology and chemistry.

Piroxicam reverses endotoxin-induced hypotension in rats: contribution of vasoactive eicosanoids and nitric oxide.

B. Tunctan, Seyhan Sahan-Firat, A. N. Sari, 2011, Basic & clinical pharmacology & toxicology.