Chengjuan Chen

发表

Methotrexate enhances antigen presentation and maturation of tumour antigen-loaded dendritic cells through NLRP3 inflammasome activation: a strategy for dendritic cell-based cancer vaccine

Yu Zhou, Tiantai Zhang, Gaona Shi, 2021, Therapeutic advances in medical oncology.

Novel 1H-pyrazolo[3,4-d]pyrimidin-6-amino derivatives as potent selective Janus kinase 3 (JAK3) inhibitors. Evaluation of their improved effect for the treatment of rheumatoid arthritis.

Lei Shu, Da-yong Zhang, Chengjuan Chen, 2020, Bioorganic chemistry.

A highly selective JAK3 inhibitor is developed for treating rheumatoid arthritis by suppressing γc cytokine–related JAK-STAT signal

Yu Zhou, Tiantai Zhang, Gaona Shi, 2022, Science advances.

Structure-based design and synthesis of 1H-pyrazolo[3,4-d]pyrimidin-4-amino derivatives as Janus kinase 3 inhibitors.

Da-yong Zhang, Chengjuan Chen, Tian-tai Zhang, 2018, Bioorganic & medicinal chemistry.

Exploring a novel triptolide derivative possess anti-colitis effect via regulating T cell differentiation.

Yu Zhou, Tiantai Zhang, Dongming Zhang, 2021, International immunopharmacology.

Discovery and evaluation of ZT55, a novel highly-selective tyrosine kinase inhibitor of JAK2V617F against myeloproliferative neoplasms

Chao Yang, Tiantai Zhang, Dan Zhang, 2019, Journal of Experimental & Clinical Cancer Research.

JAK3 inhibitors for the treatment of inflammatory and autoimmune diseases: a patent review (2016–present)

D. Lu, Tiantai Zhang, Tao Sun, 2021, Expert opinion on therapeutic patents.

Novel nitric oxide-releasing derivatives of triptolide as antitumor and anti-inflammatory agents: Design, synthesis, biological evaluation, and nitric oxide release studies.

Fang-fang Lai, Xiaoguang Chen, Ke Liu, 2020, European journal of medicinal chemistry.

Structure-based design and synthesis of pyrimidine-4,6-diamine derivatives as Janus kinase 3 inhibitors.

Lei Shu, Da-yong Zhang, Chengjuan Chen, 2019, Bioorganic & medicinal chemistry.

Celastrol Targets Cullin-Associated and Neddylation-Dissociated 1 to Prevent Fibroblast-Myofibroblast Transformation against Pulmonary Fibrosis.

Yu Zhou, Dongmei Wang, Tianming Yang, 2022, ACS chemical biology.

Isotalatizidine, a C19-diterpenoid alkaloid, attenuates chronic neuropathic pain through stimulating ERK/CREB signaling pathway-mediated microglial dynorphin A expression

Yu Zhou, Huan Xia, Tiantai Zhang, 2020, Journal of Neuroinflammation.

The Anti-Allergic Rhinitis Effect of Traditional Chinese Medicine of Shenqi by Regulating Mast Cell Degranulation and Th1/Th2 Cytokine Balance

Xiaoju Shi, Min Hu, Chengjuan Chen, 2017, Molecules.

Emerging small-molecule inhibitors of the Bruton's tyrosine kinase (BTK): Current development.

Dongmei Wang, Tiantai Zhang, Jie Zhang, 2021, European journal of medicinal chemistry.

A novel triptolide derivative ZT01 exerts anti-inflammatory effects by targeting TAK1 to prevent macrophage polarization into pro-inflammatory phenotype.

Yu Zhou, Tiantai Zhang, Dongming Zhang, 2020, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Divanillyl sulfone suppresses NLRP3 inflammasome activation via inducing mitophagy to ameliorate chronic neuropathic pain in mice

Yu Zhou, Qing-lan Guo, Gaona Shi, 2021, Journal of Neuroinflammation.

Design, synthesis, and pharmacological evaluation of 4- or 6-phenyl-pyrimidine derivatives as novel and selective Janus kinase 3 inhibitors.

Lei Shu, Tiantai Zhang, Da-yong Zhang, 2020, European journal of medicinal chemistry.

Quercetin impedes Th17 cell differentiation to mitigate arthritis involving PPARγ-driven transactivation of SOCS3 and redistribution corepressor SMRT from PPARγ to STAT3.

Gaona Shi, Xin Wu, Yan Yang, 2022, Molecular nutrition & food research.

Therapeutic potential of the target on NLRP3 inflammasome in multiple sclerosis.

Lei Wu, Yu Zhou, Tiantai Zhang, 2021, Pharmacology & therapeutics.

Machine Learning Models Based on Molecular Fingerprints and an Extreme Gradient Boosting Method Lead to the Discovery of JAK2 Inhibitors

Xiaojian Wang, Minjian Yang, Wenqiang Jia, 2019, J. Chem. Inf. Model..

Discovery of novel selective Janus kinase 2 (JAK2) inhibitors bearing a 1H-pyrazolo[3,4-d]pyrimidin-4-amino scaffold.

Lei Shu, Da-yong Zhang, Chengjuan Chen, 2019, Bioorganic & medicinal chemistry.

Discovery and evaluation of ZT55, a novel highly-selective tyrosine kinase inhibitor of JAK2V617F against myeloproliferative neoplasms

Chao Yang, Tiantai Zhang, Dan Zhang, 2019, Journal of experimental & clinical cancer research : CR.

Design, synthesis, and evaluation of isoflavone analogs as multifunctional agents for the treatment of Alzheimer's disease.

Dongmei Wang, Song Wu, Xinpeng Li, 2019, European journal of medicinal chemistry.

Bone-derived MSCs encapsulated in alginate hydrogel prevent collagen-induced arthritis in mice through the activation of adenosine A2A/2B receptors in tolerogenic dendritic cells

Lei Wu, Xinlong Yan, Yu Zhou, 2023, Acta pharmaceutica Sinica. B.

JAK inhibition ameliorated experimental autoimmune encephalomyelitis by blocking GM-CSF-driven inflammatory signature of monocytes

Lei Wu, Yu Zhou, Tiantai Zhang, 2023, Acta pharmaceutica Sinica. B.

Methyl Salicylate Lactoside Protects Neurons Ameliorating Cognitive Disorder Through Inhibiting Amyloid Beta-Induced Neuroinflammatory Response in Alzheimer’s Disease

Xiaowei Ma, Tiantai Zhang, Dongming Zhang, 2018, Front. Aging Neurosci..

A synthetic derivative of bioactive constituents from Isatis indigotica ameliorates hypersensitivity and arthritis by inhibiting JAK2-STAT3 pathway in mice.

Lei Wu, Yu Zhou, Tiantai Zhang, 2023, International immunopharmacology.

Emerging interleukin-1 receptor-associated kinase 4 (IRAK4) inhibitors or degraders as therapeutic agents for autoimmune diseases and cancer

Tiantai Zhang, Chengjuan Chen, Yifan Feng, 2024, Acta Pharmaceutica Sinica B.