Lucas A Horn

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Radiotherapy Both Promotes and Inhibits Myeloid-Derived Suppressor Cell Function: Novel Strategies for Preventing the Tumor-Protective Effects of Radiotherapy

S. Ostrand-Rosenberg, Lucas A Horn, Nicholas G. Ciavattone, 2019, Front. Oncol..

Survival of the fittest: how myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment

S. Ostrand-Rosenberg, Daniel W. Beury, K. Parker, 2019, Cancer Immunology, Immunotherapy.

High‐mobility group box protein 1 promotes the survival of myeloid‐derived suppressor cells by inducing autophagy

S. Ostrand-Rosenberg, K. Parker, Lucas A Horn, 2016, Journal of leukocyte biology.

Tumor‐induced myeloid‐derived suppressor cell function is independent of IFN‐γ and IL‐4Rα

P. Sinha, S. Ostrand-Rosenberg, K. Parker, 2012, European journal of immunology.

CD3xPDL1 bi-specific T cell engager (BiTE) simultaneously activates T cells and NKT cells, kills PDL1+ tumor cells, and extends the survival of tumor-bearing humanized mice

P. Sinha, S. Ostrand-Rosenberg, V. Clements, 2017, Oncotarget.

The Use of a Humanized NSG-β2m−/− Model for Investigation of Immune and Anti-tumor Effects Mediated by the Bifunctional Immunotherapeutic Bintrafusp Alfa

J. Schlom, J. Greiner, C. Jochems, 2020, Frontiers in Oncology.

Inhibition of MDSC Trafficking with SX-682, a CXCR1/2 Inhibitor, Enhances NK-Cell Immunotherapy in Head and Neck Cancer Models

J. Schlom, J. Friedman, C. Allen, 2019, Clinical Cancer Research.

Priority Brief A Soluble Form of CD 80 Enhances Antitumor Immunity by Neutralizing Programmed Death Ligand-1 and Simultaneously Providing Costimulation

S. Ostrand-Rosenberg, S. Haile, Lucas A Horn, 2014 .

Tumor-targeted interleukin-12 synergizes with entinostat to overcome PD-1/PD-L1 blockade-resistant tumors harboring MHC-I and APM deficiencies

J. Schlom, Paul L. Chariou, S. Gameiro, 2022, Journal for ImmunoTherapy of Cancer.

HMGB1 enhances immune suppression by facilitating the differentiation and suppressive activity of myeloid-derived suppressor cells.

K. Tracey, Huan Yang, P. Sinha, 2014, Cancer research.

Phagocytic ability declines with age in adult Drosophila hemocytes

J. Leips, M. Starz-Gaiano, Lucas A Horn, 2014, Aging cell.

Age- and diet-specific effects of variation at S6 kinase on life history, metabolic, and immune response traits in Drosophila melanogaster.

J. Leips, M. Starz-Gaiano, M. De Luca, 2010, DNA and cell biology.

Soluble CD80 Protein Delays Tumor Growth and Promotes Tumor-Infiltrating Lymphocytes

S. Ostrand-Rosenberg, Tiha M. Long, V. Clements, 2017, Cancer Immunology Research.

Soluble CD 80 Protein Delays Tumor Growth and Promotes Tumor-In fi ltrating Lymphocytes

S. Ostrand-Rosenberg, Tiha M. Long, V. Clements, 2017 .

Interleukin-8: A chemokine at the intersection of cancer plasticity, angiogenesis, and immune suppression.

Kristen Fousek, C. Palena, Lucas A Horn, 2020, Pharmacology & therapeutics.

Tumor Plasticity and Resistance to Immunotherapy.

Kristen Fousek, C. Palena, Lucas A Horn, 2020, Trends in cancer.

Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity

J. Schlom, Kristen K. McCampbell, Kristen Fousek, 2020, Journal for ImmunoTherapy of Cancer.

Inhibiting myeloid-derived suppressor cell trafficking enhances T cell immunotherapy.

J. Schlom, C. Van Waes, J. Friedman, 2019, JCI insight.

The Programmed Death-1 Immune-Suppressive Pathway: Barrier to Antitumor Immunity

S. Ostrand-Rosenberg, S. Haile, Lucas A Horn, 2014, The Journal of Immunology.

A Soluble Form of CD80 Enhances Antitumor Immunity by Neutralizing Programmed Death Ligand-1 and Simultaneously Providing Costimulation

S. Ostrand-Rosenberg, S. Haile, Lucas A Horn, 2014, Cancer Immunology Research.

Remodeling the tumor microenvironment via blockade of LAIR-1 and TGF-β signaling enables PD-L1–mediated tumor eradication

J. Schlom, Paul L. Chariou, S. Langermann, 2022, The Journal of clinical investigation.

An Interleukin-15 Superagonist Enables Antitumor Ef ﬁ cacy of Natural Killer Cells Against All Molecular Variants of SCLC

J. Schlom, Kristen Fousek, Duane H. Hamilton, 2022 .

HMGB 1 Enhances Immune Suppression by Facilitating the Differentiation and Suppressive Activity of Myeloid-Derived Suppressor Cells

K. Tracey, Huan Yang, P. Sinha, 2014 .

Microenvironment and Immunology HMGB 1 Enhances Immune Suppression by Facilitating the Differentiation and Suppressive Activity of Myeloid-Derived Suppressor Cells

K. Tracey, Huan Yang, P. Sinha, 2014 .

Vaccine Increases the Diversity and Activation of Intratumoral T Cells in the Context of Combination Immunotherapy

J. Schlom, Kristen Fousek, J. Zebala, 2021, Cancers.

Combined MYC Activation and Pten Loss Are Sufficient to Create Genomic Instability and Lethal Metastatic Prostate Cancer.

C. Bieberich, J. Hicks, A. D. De Marzo, 2016, Cancer research.

Identification of Immune Cell Infiltration in Murine Pheochromocytoma during Combined Mannan-BAM, TLR Ligand, and Anti-CD40 Antibody-Based Immunotherapy

K. Pacak, J. Ženka, J. Chmelař, 2021, Cancers.

Novel strategies for inhibiting PD-1 pathway-mediated immune suppression while simultaneously delivering activating signals to tumor-reactive T cells

S. Ostrand-Rosenberg, Lucas A Horn, Juan Alvarez, 2015, Cancer Immunology, Immunotherapy.

Fulvestrant increases the susceptibility of enzalutamide-resistant prostate cancer cells to NK-mediated lysis

Kristen Fousek, Duane H. Hamilton, C. Palena, 2023, Journal for ImmunoTherapy of Cancer.

An IL-15 superagonist enables anti-tumor efficacy of NK cells against all molecular variants of small cell lung cancer (SCLC).

J. Schlom, Anish Thomas, Kristen Fousek, 2022, Journal of Thoracic Oncology.