A. Boal

发表

Biochemical Approaches to Probe the Role of the Auxiliary Iron-Sulfur Cluster of Lipoyl Synthase from Mycobacterium Tuberculosis.

S. Booker, V. R. Jeyachandran, Jay V Pendyala, 2021, Methods in molecular biology.

α-Amine Desaturation of d-Arginine by the Iron(II)- and 2-(Oxo)glutarate-Dependent l-Arginine 3-Hydroxylase, VioC.

C. Krebs, J. Bollinger, N. P. Dunham, 2018, Biochemistry.

A Substrate-triggered µ-Peroxodiiron(III) Intermediate in the 4-Chloro-L-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate

Michelle C. Y. Chang, C. Krebs, J. Bollinger, 2021, bioRxiv.

Structural Basis for Superoxide Activation of Flavobacterium johnsoniae Class I Ribonucleotide Reductase and for Radical Initiation by Its Dimanganese Cofactor.

C. Pollock, C. Krebs, J. Bollinger, 2018, Biochemistry.

Structural basis for assembly of the Mn(IV)/Fe(III) cofactor in the class Ic ribonucleotide reductase from Chlamydia trachomatis.

C. Krebs, J. Bollinger, A. Rosenzweig, 2013, Biochemistry.

Two Distinct Mechanisms for C-C Desaturation by Iron(II)- and 2-(Oxo)glutarate-Dependent Oxygenases: Importance of α-Heteroatom Assistance.

C. Krebs, J. Bollinger, Bo Zhang, 2018, Journal of the American Chemical Society.

Structure-Guided Reprogramming of a Hydroxylase To Halogenate Its Small Molecule Substrate.

Xinyu Liu, Wei‐chen Chang, N. P. Dunham, 2017, Biochemistry.

Substrate-triggered Formation of a Peroxo-Fe2(III/III) Intermediate during Fatty Acid Decarboxylation by UndA.

C. Krebs, J. Bollinger, Bo Zhang, 2019, Journal of the American Chemical Society.

DNA-bound redox activity of DNA repair glycosylases containing [4Fe-4S] clusters.

J. Barton, E. Yavin, V. O'shea, 2005, Biochemistry.

Structural Basis for Activation of Class Ib Ribonucleotide Reductase

A. Rosenzweig, J. Stubbe, J. Cotruvo, 2010, Science.

The immune system mimics a pathogen

A. Boal, 2019, Science.

SznF, a Metalloenzyme Employed in the Biosynthesis of Streptozotocin

M. McBride, A. Boal, 2021, Encyclopedia of Inorganic and Bioinorganic Chemistry.

AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress.

Xueyuan Jiang, N. P. Dunham, Kun Miao, 2017, Angewandte Chemie.

Use of Non-canonical Tyrosine Analogs to Probe Control of Radical Intermediates during Endoperoxide Installation by Verruculogen Synthase (FtmOx1)

C. Krebs, A. Silakov, Chi-Yun Lin, 2022 .

Structural insights into auxiliary cofactor usage by radical S-adenosylmethionine enzymes.

V. R. Jeyachandran, A. Boal, 2022, Current opinion in chemical biology.

Electrochemical detection of lesions in DNA.

J. Barton, A. Boal, 2005, Bioconjugate chemistry.

A peroxodiiron(III) intermediate mediating both N-hydroxylation steps in biosynthesis of the N-nitrosourea pharmacophore of streptozotocin by SznF.

C. Krebs, J. Bollinger, Grace E Kenney, 2020, Journal of the American Chemical Society.

An Iron(IV)-Oxo Intermediate Initiating l-Arginine Oxidation but Not Ethylene Production by the 2-Oxoglutarate-Dependent Oxygenase, Ethylene-Forming Enzyme.

C. Krebs, J. Bollinger, K. Davis, 2021, Journal of the American Chemical Society.

Facile and E-selective intramolecular ring-closing metathesis reactions in 3(10)-helical peptides: a 3D structural study.

C. Toniolo, M. Crisma, A. Moretto, 2007, Journal of the American Chemical Society.

Mechanisms of 2-oxoglutarate-dependent oxygenases: The hydroxylation paradigm and beyond

C. Krebs, J. Bollinger, Wei‐chen Chang, 2015 .

Structure of a ferryl mimic in the archetypal iron(II)- and 2-(oxo)-glutarate-dependent dioxygenase, TauD.

C. Krebs, J. Bollinger, K. Davis, 2019, Biochemistry.

A New Microbial Pathway for Organophosphonate Degradation Catalyzed by Two Previously Misannotated Non-Heme-Iron Oxygenases.

C. Krebs, J. Bollinger, Bo Zhang, 2019, Biochemistry.

Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase.

Benjamin D. Allen, C. Pollock, C. Krebs, 2017, Journal of the American Chemical Society.

Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

M. L. Hillwig, Xinyu Liu, A. Mitchell, 2016, Nature chemical biology.

Assembly of the unusual oxacycles in the orthosomycin antibiotics

J. Bollinger, Wei‐chen Chang, A. Boal, 2015, Proceedings of the National Academy of Sciences.

The periodic table of ribonucleotide reductases

A. K. Boal, Terry B. Ruskoski, A. Boal, 2021, The Journal of biological chemistry.

The dimanganese(II) site of Bacillus subtilis class Ib ribonucleotide reductase.

A. Rosenzweig, J. Stubbe, J. Cotruvo, 2012, Biochemistry.

Rerouting the Pathway for the Biosynthesis of the Side Ring System of Nosiheptide: The Roles of NosI, NosJ, and NosK

T. Grove, S. Booker, A. Boal, 2017, Journal of the American Chemical Society.

Evidence that the β subunit of Chlamydia trachomatis ribonucleotide reductase is active with the manganese ion of its manganese(IV)/iron(III) cofactor in site 1.

C. Krebs, J. Bollinger, A. Rosenzweig, 2012, Journal of the American Chemical Society.

Hydrogen Donation but not Abstraction by a Tyrosine (Y68) during Endoperoxide Installation by Verruculogen Synthase (FtmOx1).

Benjamin D. Allen, C. Krebs, J. Bollinger, 2019, Journal of the American Chemical Society.

The Cation−π Interaction Enables a Halo-Tag Fluorogenic Probe for Fast No-Wash Live Cell Imaging and Gel-Free Protein Quantification

A. K. Boal, Xiaosong Li, Hongbin Liu, 2017, Biochemistry.

Steric enforcement of cis-epoxide formation in the radical C-O-coupling reaction by which (S)-2-hydroxypropylphosphonate epoxidase (HppE) produces Fosfomycin.

Shengbin Zhou, C. Krebs, J. Bollinger, 2019, Journal of the American Chemical Society.

Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

C. Krebs, J. Bollinger, A. Rosenzweig, 2014, Science.

Structural biology of copper trafficking.

A. Rosenzweig, A. Boal, 2009, Chemical reviews.

Crystal structures of cisplatin bound to a human copper chaperone.

A. Rosenzweig, A. Boal, 2009, Journal of the American Chemical Society.

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

E. Balskus, A. Mitchell, R. Rohac, 2018, Nature.

DNA-mediated charge transport in redox sensing and signaling.

Joseph C Genereux, Jacqueline K Barton, J. Barton, 2010, Journal of the American Chemical Society.

Protein-DNA charge transport: redox activation of a DNA repair protein by guanine radical.

Elizabeth M. Boon, Alison L. Livingston, J. Barton, 2005, Proceedings of the National Academy of Sciences of the United States of America.

An endogenous dAMP ligand in Bacillus subtilis class Ib RNR promotes assembly of a noncanonical dimer for regulation by dATP

S. Meisburger, W. Thomas, N. Ando, 2018, Proceedings of the National Academy of Sciences.

Discovery, structure and mechanism of a tetraether lipid synthase

W. Metcalf, Matteo Cossu, Bo Wang, 2022, Nature.

Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA

T. Grove, Erica L. Schwalm, S. Booker, 2016, Science.

Organophosphonate-degrading PhnZ reveals an emerging family of HD domain mixed-valent diiron oxygenases

C. Krebs, J. Bollinger, N. Yennawar, 2013, Proceedings of the National Academy of Sciences.

Drop-on-demand sample delivery for studying biocatalysts in action at X-ray free-electron lasers

Uwe Bergmann, Henrik Lemke, Mengning Liang, 2017, Nature Methods.

Emerging Structural and Functional Diversity in Proteins With Dioxygen-Reactive Dinuclear Transition Metal Cofactors

C. Krebs, J. Bollinger, A. K. Boal, 2020 .

DNA repair glycosylases with a [4Fe-4S] cluster: a redox cofactor for DNA-mediated charge transport?

J. Barton, E. Yavin, A. Boal, 2007, Journal of inorganic biochemistry.

Biochemical and Structural Characterization of XoxG and XoxJ and Their Roles in Lanthanide‐Dependent Methanol Dehydrogenase Activity

J. Cotruvo, M. McBride, Hannah R. Rose, 2019, Chembiochem : a European journal of chemical biology.

Structural basis for an unprecedented enzymatic alkylation in cylindrocyclophane biosynthesis

K. Davis, E. Balskus, N. Glasser, 2021, bioRxiv.

Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis

C. Townsend, H. Knox, S. Booker, 2022, Nature.

Structure and assembly of the diiron cofactor in the heme-oxygenase-like domain of the N-nitrosourea-producing enzyme SznF

J. Bollinger, C. Okafor, A. K. Boal, 2020, bioRxiv.

Inhibition of DNA transcription using cationic mixed monolayer protected gold clusters.

V. Rotello, A. K. Boal, C. M. McIntosh, 2001, Journal of the American Chemical Society.

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

Squire J. Booker, Neela H. Yennawar, A. Rosenzweig, 2011, Science.

Redox signaling between DNA repair proteins for efficient lesion detection

J. Barton, D. Newman, Joseph C. Genereux, 2009, Proceedings of the National Academy of Sciences.

Metal-free class Ie ribonucleotide reductase from pathogens initiates catalysis with a tyrosine-derived dihydroxyphenylalanine radical

Benjamin D. Allen, R. Griffin, C. Krebs, 2018, Proceedings of the National Academy of Sciences.

Streptococcus sanguinis Class Ib Ribonucleotide Reductase

A. Rosenzweig, O. Makhlynets, J. Stubbe, 2013, The Journal of Biological Chemistry.

Structures of Class Id Ribonucleotide Reductase Catalytic Subunits Reveal a Minimal Architecture for Deoxynucleotide Biosynthesis.

A. K. Boal, N. Yennawar, K. Davis, 2019, Biochemistry.

Structure-Function Relationships in Assembly of the Radical-Initiating Cofactors of Class Ia–e Ribonucleotide Reductases

K. Hu, A. Gandhi, Hannah R. Rose, 2020 .

Structural Biology of Copper Trafficking

A. Rosenzweig, A. Boal, 2010 .

Intrinsically disordered substrates dictate SPOP subnuclear localization and ubiquitination activity

N. Sabri, S. Showalter, T. Mittag, 2021, The Journal of biological chemistry.

Direct electrochemistry of endonuclease III in the presence and absence of DNA.

J. Barton, A. K. Boal, A. Gorodetsky, 2006, Journal of the American Chemical Society.

Biological contexts for DNA charge transport chemistry.

J. Barton, Edward J. Merino, A. Boal, 2008, Current opinion in chemical biology.

Response from Boal and Rosenzweig to Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.

A. Rosenzweig, A. Boal, 2015, Acta Crystallographica Section D: Biological Crystallography.

Mechanism-Based Strategies for Structural Characterization of Radical SAM Reaction Intermediates.

K. Davis, A. Boal, 2017, Methods in enzymology.

Use of Noncanonical Tyrosine Analogues to Probe Control of Radical Intermediates during Endoperoxide Installation by Verruculogen Synthase (FtmOx1).

C. Krebs, J. Bollinger, Chi-Yun Lin, 2022, ACS catalysis.

Structure of a B12-dependent radical SAM enzyme in carbapenem biosynthesis

C. Townsend, H. Knox, S. Booker, 2022, Nature.

Structural basis for carbapenam C-alkylation by TokK, a B12-dependent radical SAM enzyme

C. Townsend, H. Knox, S. Booker, 2021, bioRxiv.

An N-nitrosating metalloenzyme constructs the pharmacophore of streptozotocin

E. Balskus, A. Mitchell, R. Rohac, 2018, Nature.

Enhanced rare-earth separation with a metal-sensitive lanmodulin dimer

N. Yennawar, Ziye Dong, Joseph A. Mattocks, 2023, Nature.

A Radical Route for Nitrogenase Carbide Insertion

A. Rosenzweig, A. K. Boal, A. Boal, 2012, Science.

Analysis of RNA methylation by phylogenetically diverse Cfr radical SAM enzymes reveals an iron-binding accessory domain in a clostridial enzyme.

C. Krebs, Ryan J. Martinie, S. Booker, 2019, Biochemistry.

for Structures of class Id ribonucleotide reductase catalytic subunits reveal a minimal architecture for deoxynucleotide biosynthesis

N. Yennawar, K. Davis, M. Pandelia, 2019 .

Structural biology of copper trafficking.

A. Rosenzweig, A. Boal, 2009, Chemical reviews.

Structural Basis for Activation of Class Ib Ribonucleotide Reductase

A. Rosenzweig, J. Stubbe, J. Cotruvo, 2010, Science.

Actinobacillus ureae class Id ribonucleotide reductase alpha subunit

N. Yennawar, M. Pandelia, M. McBride, 2019 .

MIT Open Access Articles The Dimanganese(II) Site of Bacillus subtilis Class Ib Ribonucleotide Reductase

J. Cotruvo, A. Boal, JoAnne Stubbe, 2022 .

Substrate-Triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-l-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate.

Michelle C. Y. Chang, C. Krebs, J. Bollinger, 2022, Biochemistry.

Structure and assembly of the diiron cofactor in the heme-oxygenase–like domain of the N-nitrosourea–producing enzyme SznF

E. Balskus, M. McBride, A. Boal, 2021, Proceedings of the National Academy of Sciences.

Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA

T. Grove, Erica L. Schwalm, S. Booker, 2016, Science.

Supplementary Materials for Mechanism of the C5 Stereoinversion Reaction in the Biosynthesis of Carbapenem Antibiotics

C. Krebs, J. Bollinger, A. Rosenzweig, 2014 .

Optimized Substrate Positioning Enables Switches in the C-H Cleavage Site and Reaction Outcome in the Hydroxylation-Epoxidation Sequence Catalyzed by Hyoscyamine 6β-Hydroxylase.

Ryan J. Martinie, Debangsu Sil, C. Pollock, 2024, Journal of the American Chemical Society.

Synergistic Binding of the Halide and Cationic Prime Substrate of l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States.

C. Krebs, J. Bollinger, Debangsu Sil, 2023, Biochemistry.

Synergistic Binding of the Halide and Cationic Prime Substrate of the l-Lysine 4-Chlorinase, BesD, in Both Ferrous and Ferryl States

C. Krebs, Debangsu Sil, Chi-Yun Lin, 2023, bioRxiv.