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Discovery of novel serine palmitoyltransferase inhibitors as cancer therapeutic agents.

Yuta Tanaka, B. Saito, Kazunobu Aoyama, 2018, Bioorganic & medicinal chemistry.

Loss of lysophospholipase 3 increases atherosclerosis in apolipoprotein E-deficient mice.

Y. Taniyama, R. Tozawa, M. Nakata, 2005, Biochemical and biophysical research communications.

Ameliorative effect of phosphodiesterase 4 and 5 inhibitors in deoxycorticosterone acetate‐salt hypertensive uni‐nephrectomized KKAy mice

Mitsugi Ookawara, T. Matsuo, K. Tohyama, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Synthesis and evaluation of hedgehog signaling inhibitor with novel core system.

S. Sasaki, T. Ohashi, Yuta Tanaka, 2015, Bioorganic & medicinal chemistry.

DMD049650 727..734

H. Tojo, S. Asahi, W. Shyu, 2013 .

Improvement of pulmonary arterial hypertension, inflammatory response, and epithelium injury by dual activation of cAMP/cGMP pathway in a rat model of monocrotaline-induced pulmonary hypertension

T. Matsuo, K. Tohyama, Yo Muraki, 2019, Bioscience, biotechnology, and biochemistry.

Identification of the first highly selective inhibitor of human lactate dehydrogenase B

T. Soga, N. Takakura, T. Kawamoto, 2020, Scientific Reports.

A new brain‐penetrant glucosylceramide synthase inhibitor as potential Therapeutics for Gaucher disease

H. Oki, Yuta Tanaka, T. Onishi, 2021, Journal of neurochemistry.

Discovery of Novel 5-(Piperazine-1-carbonyl)pyridin-2(1H)-one Derivatives as Orally eIF4A3-Selective Inhibitors.

K. Fukuda, Y. Imaeda, Y. Kosugi, 2017, ACS medicinal chemistry letters.

Discovery of pyrrolo[3,2-c]quinoline-4-one derivatives as novel hedgehog signaling inhibitors.

S. Sasaki, T. Ohashi, H. Tojo, 2012, Bioorganic & medicinal chemistry.

CETSA quantitatively verifies in vivo target engagement of novel RIPK1 inhibitors in various biospecimens

M. Yoshikawa, M. Mochizuki, Tsuyoshi Ishii, 2017, Scientific Reports.

Antitumor activity of a novel and orally available inhibitor of serine palmitoyltransferase.

R. Adachi, Atsushi Kiba, M. Hirayama, 2017, Biochemical and biophysical research communications.

Molecular mechanism and potential target indication of TAK-931, a novel CDC7-selective inhibitor

K. Burke, Jie Yu, T. Miyazaki, 2019, Science Advances.

Molecular mechanism and potential target indication of TAK-931 , a novel CDC 7-selective inhibitor

K. Burke, Jie Yu, T. Miyazaki, 2019 .

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.

S. Sasaki, T. Ohashi, Yuta Tanaka, 2012, Bioorganic & medicinal chemistry.

Pharmacokinetic and Pharmacodynamic Modeling of Hedgehog Inhibitor TAK-441 for the Inhibition of Gli1 messenger RNA Expression and Antitumor Efficacy in Xenografted Tumor Model Mice

Maki Miyamoto, Wen Chyi Shyu, Takahiro Kondo, 2013, Drug Metabolism and Disposition.

Discovery of the investigational drug TAK-441, a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor: modification of the core skeleton for improved solubility.

S. Sasaki, T. Ohashi, Yuta Tanaka, 2012, Bioorganic & medicinal chemistry.

Abstract 2823: TAK-441, a novel investigational small molecule hedgehog pathway inhibitor for use in cancer therapy

M. Kawamura, S. Sasaki, H. Tojo, 2011 .