I. Manzanares

发表

The potent anticancer compound ecteinascidin-743 (ET-743) as its 2-propanol disolvate.

C. I. Sainz-Díaz, I. Manzanares, A. Francesch, 2003, Acta crystallographica. Section C, Crystal structure communications.

Synthesis of Ecteinascidin 743 Analogues from Cyanosafracin B: Isolation of a Kinetically Stable Quinoneimine Tautomer of a 5‐Hydroxyindole

C. Cuevas, A. Echavarren, A. Francesch, 2006 .

DNA and non-DNA targets in the mechanism of action of the antitumor drug trabectedin.

O. Olmea, C. Bailly, F. Mollinedo, 2005, Chemistry & biology.

Search for metabolites of ecteinascidin 743, a novel, marine-derived, anti-cancer agent, in man

J. Schellens, H. Rosing, J. Beijnen, 2001, Anti-cancer drugs.

Increased DNA binding specificity for antitumor ecteinascidin 743 through protein-DNA interactions?

F. Gago, R. García-Nieto, I. Manzanares, 2000, Journal of medicinal chemistry.

Effects of substituents on the chlorination of methyl 3‐hydroxythiophene‐2‐carboxylate and on the reaction of the resulting chlorinated products with active hydrogen containing compounds

I. Manzanares, C. Corral, J. Lissavetzky, 1990 .

Synthesis and cytotoxic evaluation of new derivatives of the marine alkaloid variolin B.

P. Molina, C. Cuevas, A. Francesch, 2006, Journal of medicinal chemistry.

Total syntheses of variolin B and deoxyvariolin B.

F. Albericio, C. Cuevas, J. Joule, 2003, The Journal of organic chemistry.

Synthesis of variolin B

F. Albericio, C. Cuevas, J. Joule, 2003 .

Benzo[f]azino[2,1-a]phthalazinium cations: novel DNA intercalating chromophores with antiproliferative activity.

J. Vaquero, F. Gago, J. Alvarez-Builla, 2004, Journal of medicinal chemistry.

Topoisomerase I-mediated DNA cleavage as a guide to the development of antitumor agents derived from the marine alkaloid lamellarin D: triester derivatives incorporating amino acid residues.

C. Bailly, C. Tardy, C. Cuevas, 2004, Bioorganic & medicinal chemistry.

Solid-phase total synthesis of the pentacyclic system lamellarins U and L.

Pablo Cironi, F. Albericio, M. Álvarez, 2003, Organic letters.

Stereochemistry of kahalalide F.

K. Rinehart, I. Bonnard, I. Manzanares, 2003, Journal of Natural Products.

Lamellarin D: a novel potent inhibitor of topoisomerase I.

Christian Bailly, Michaël Facompré, Ignacio Manzanares, 2003, Cancer research.

Total synthesis and biological evaluation of tamandarin B analogues.

C. Cuevas, M. Joullié, J. Adrio, 2007, The Journal of organic chemistry.

Solid Phase Synthesis of Lamellarins

Pablo Cironi, F. Albericio, M. Álvarez, 2003 .

Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potential antidepressant drugs.

V. Darias, C. Sánchez-Mateo, I. Manzanares, 1999, Bioorganic & medicinal chemistry.

DIELS-ALDER REACTION OF METHOXYTHIOPHENES : A NEW ONE-POT SYNTHESIS OF DIMETHYL PHTHALATES

I. Manzanares, C. Corral, J. Lissavetzky, 1997 .

Validation of a sensitive assay for thiocoraline in mouse plasma using liquid chromatography-tandem mass spectrometry.

P. Avilés, P. Calvo, G. Faircloth, 2003, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Solid-phase total synthesis of trunkamide A(1).

E. Giralt, F. Albericio, I. Manzanares, 2001, The Journal of organic chemistry.

A 3.(ET743)-DNA complex that both resembles an RNA-DNA hybrid and mimicks zinc finger-induced DNA structural distortions.

J. Mendieta, F. Gago, E. Marco, 2002, Journal of medicinal chemistry.

In vitro activity of aplidine, a new marine-derived anti-cancer compound, on freshly explanted clonogenic human tumour cells and haematopoietic precursor cells.

J. Jimeno, G. Faircloth, A. Hanauske, 1998, British Journal of Cancer.

Ecteinascidins: Putative Biosynthetic Precursors and Absolute Stereochemistry

R. Sakai, K. Rinehart, E. Jares-Erijman, 1996 .

Advances in the chemistry and pharmacology of ecteinascidins, a promising new class of anti-cancer agents.

F. Gago, E. Marco, R. García-Nieto, 2001, Current medicinal chemistry. Anti-cancer agents.

Reactions of methyl 3-hydroxythiophene-2-carboxylate. Part 4. Synthesis of methyl 5-azolyl-3-hydroxythiophene-2-carboxylates

I. Manzanares, M. El-Ashmawy, C. Corral, 1987 .

Synthesis and biological evaluation of tamandarin B analogues.

C. Cuevas, M. Joullié, J. Adrio, 2006, Organic letters.

Synthesis of ecteinascidin ET-743 and phthalascidin Pt-650 from cyanosafracin B.

F. de la Calle, C Cuevas, M Pérez, 2000, Organic letters.

In vitro characterization of the human biotransformation pathways of aplidine, a novel marine anti-cancer drug

J. Schellens, J. Beijnen, E. Brandon, 2007, Investigational New Drugs.

Synthesis of natural ecteinascidins (ET-729, ET-745, ET-759B, ET-736, ET-637, ET-594) from cyanosafracin B.

Natividad Rodríguez, Alberto Rodríguez, Valentín Martínez, 2003, The Journal of organic chemistry.

SYNTHESIS, STRUCTURE, AND ANTIMALARIAL ACTIVITY OF SOME ENANTIOMERICALLY PURE, CIS-FUSED CYCLOPENTENO-1,2,4-TRIOXANES

G. Bernardinelli, U. Burger, J. Mareda, 1995 .

Bending of DNA upon Binding of Ecteinascidin 743 and Phthalascidin 650 Studied by Unrestrained Molecular Dynamics Simulations

F. Gago, R. García-Nieto, I. Manzanares, 2000 .

Ecteinascidins: Putative Biosynthetic Precursors and Absolute Stereochemistry.

R. Sakai, K. Rinehart, E. Jares-Erijman, 1997 .