J. Spencer

发表

J. Klinowski, J. Staunton, P. Gates, 2003 .

Molecular engineering of a backwards-moving myosin motor

J. Naismith, D. O'Hagan, H. Deng, 2022 .

Heterogeneous transfer hydrogenation involves pairwise hydrogen transfer from the same position of two molecules of formic acid

J. Spencer, Jinquan Yu, 1998 .

Identification of a Deacetylase Involved in the Maturation of Teicoplanin

A. Truman, J. Spencer, Louisa Robinson, 2006, Chembiochem : a European journal of chemical biology.

Crystal structures of the PLP‐ and PMP‐bound forms of BtrR, a dual functional aminotransferase involved in butirosin biosynthesis

T. Blundell, D. Chirgadze, B. Popovic, 2006, Proteins.

Biosynthesis of 2-deoxystreptamine-containing aminoglycoside antibiotics.

J. Spencer, Nicholas M. Llewellyn, 2006, Natural product reports.

Convenient synthesis of 2-deoxy-scyllo-inosose and 2-deoxy-scyllo-inosamine: two key intermediates on the biosynthetic pathway to aminoglycoside antibiotics

J. Spencer, Jinquan Yu, 2001 .

Biosynthesis of aminoglycoside antibiotics: cloning, expression and characterisation of an aminotransferase involved in the pathway to 2-deoxystreptamine.

F. Huang, Yanyan Li, J. Spencer, 2002, Chemical communications.

Direct comparison between the mechanism of hydrometalation and β-elimination in heterogeneous and homogeneous hydrogenation

J. Spencer, Jinquan Yu, P. Whitney, 1999 .

Characterisation of a sugar epimerase enzyme involved in the biosynthesis of a vancomycin-group antibiotic

Dudley H. Williams, Hung‐wen Liu, W. Scaife, 2000 .

The role of cep15 in the biosynthesis of chloroeremomycin: reactivation of an ancestral catalytic function.

P. Leadlay, A. Truman, E. Stegmann, 2008, Chemistry & biology.

Biosynthesis of butirosin: transfer and deprotection of the unique amino acid side chain.

Yanyan Li, J. Spencer, Nicholas M. Llewellyn, 2007, Chemistry & biology.

Expression and assay of an N-methyltransferase involved in the biosynthesis of a vancomycin group antibiotic

Dudley H. Williams, A. Hopkinson, T. I. Richardson, 2000 .

Sequential removal of the benzyl-type protecting groups PMB and NAP by oxidative cleavage using CAN and DDQ

Joseph A. Wright, Joseph A Wright, J. Spencer, 2001 .

Novel anti-Markovnikov regioselectivity in the Wacker reaction of styrenes.

Joseph A. Wright, Joseph A Wright, M. Gaunt, 2006, Chemistry.

Molecular basis of Celmer's rules: stereochemistry of catalysis by isolated ketoreductase domains from modular polyketide synthases.

P. Leadlay, J. Staunton, V. Stein, 2005, Chemistry & biology.

Biological chemistry: Enzymes line up for assembly

J. Spencer, Nicholas M. Llewellyn, 2007, Nature.

A general, Brønsted acid-catalyzed hetero-Michael addition of nitrogen, oxygen, and sulfur nucleophiles.

J. Spencer, Tobias C. Wabnitz, 2003, Organic letters.

Structure elucidation of a novel family of mycolactone toxins from the frog pathogen Mycobacterium sp. MU128FXT by mass spectrometry.

Hui Hong, P. Leadlay, T. Stinear, 2005, Chemical communications.

The fluorinase from Streptomyces cattleya is also a chlorinase.

J. Naismith, D. Robinson, D. O'Hagan, 2005, Angewandte Chemie.

First Evidence That the Mechanism of Catalytic Hydrogenation with Homogeneous Palladium and Rhodium Catalysts Is Strongly Influenced by Substrate Polarity

J. Spencer, Jinquan Yu, 1997 .

Covalent Linkage Mediates Communication between ACP and TE Domains in Modular Polyketide Synthases

P. Leadlay, K. Weissman, M. Tosin, 2008, Chembiochem : a European journal of chemical biology.

Malonyl carba(dethia)‐ and Malonyl oxa(dethia)‐coenzyme A as Tools for Trapping Polyketide Intermediates

D. Spiteller, M. Tosin, J. Spencer, 2009, Chembiochem : a European journal of chemical biology.

Incorporation of fluoroacetate into an aromatic polyketide and its influence on the mode of cyclization.

Hui Hong, D. Spiteller, J. Spencer, 2008, Angewandte Chemie.

Directed mutagenesis alters the stereochemistry of catalysis by isolated ketoreductase domains from the erythromycin polyketide synthase.

P. Leadlay, N. Campillo, A. Baerga-Ortiz, 2006, Chemistry & biology.

Biological Fluorination in Streptomyces cattleya : The Fluorinase

Xiaofeng Zhu, J. Naismith, D. O'Hagan, 2008 .

Crystal structure and mechanism of a bacterial fluorinating enzyme

J. Naismith, C. Dong, D. O'Hagan, 2004, Nature.

The gene cluster for fluorometabolite biosynthesis in Streptomyces cattleya: a thioesterase confers resistance to fluoroacetyl-coenzyme A.

P. Leadlay, T. Mironenko, S. Haydock, 2006, Chemistry & biology.

Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation.

M. Gaunt, J. Spencer, J. Yu, 2001, Chemical communications.

Derailing the Wacker oxidation: development of a palladium-catalyzed amidation reaction.

M. Gaunt, J. Spencer, 2001, Organic letters.

Convenient preparation of trans-arylalkenes via palladium(II)-catalyzed isomerization of cis-arylalkenes.

M. Gaunt, J. Spencer, Jinquan Yu, 2002, The Journal of organic chemistry.

Transfer hydrogenation using recyclable polyurea-encapsulated palladium: efficient and chemoselective reduction of aryl ketones.

Steven V Ley, S. Ley, Hai‐Chen Wu, 2003, Chemical communications.

Rational Design of Benzyl-Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Catalytic Hydrogenolysis

M. Gaunt, J. Spencer, Jinquan Yu, 1998 .

Evidence that protons can be the active catalysts in Lewis acid mediated hetero-Michael addition reactions.

J. Spencer, Tobias C. Wabnitz, Jinquan Yu, 2004, Chemistry.

Convenient synthesis of Cbz-protected β-amino ketones by a copper-catalysed conjugate addition reaction

J. Spencer, Tobias C. Wabnitz, 2002 .

Investigation of the mechanism and steric course of the reaction catalyzed by 6-methylsalicylic acid synthase from Penicillium patulum using (R)-[1-13C;2-2H]- and (S)-[1-13C;2-2H]malonates.

P. Jordan, J. Spencer, 1992, Biochemistry.

Mechanistic and stereochemical investigation of fatty acid and polyketide biosynthesis using chiral malonates

P. Jordan, J. Spencer, 1991 .

Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic

Hui Hong, P. Leadlay, Yuhui Sun, 2008, Chembiochem : a European journal of chemical biology.

Stereospecific deoxygenation of phosphine oxides with retention of configuration using triphenylphosphine or triethyl phosphite as an oxygen acceptor.

Hai‐Chen Wu, J. Spencer, Jinquan Yu, 2004, Organic letters.

New insight into the mechanism of catalytic hydrogenation allows the structure of the key intermediate in asymmetric hydrogenation to be predicted

J. Spencer, Jinquan Yu, Jin-Quan Yu, 1998 .

Chimeric glycosyltransferases for the generation of hybrid glycopeptides.

T. Blundell, A. Truman, M. Dias, 2009, Chemistry & biology.

Catalyst-induced changes in a substituted aromatic: A combined approach via experiment and theory

D. King, Y. Tan, S. Jenkins, 2005 .

Evidence for Direct Hydride Delivery from Formic Acid in Transfer Hydrogenation

J. Spencer, Jinquan Yu, 1999 .

Preferential hydrogenolysis of NAP esters provides a new orthogonal protecting group strategy for carboxylic acids

C. Boschetti, M. Gaunt, J. Spencer, 1999 .

Rational Design of Benzyl-Type Protecting Groups Allows Sequential Deprotection of Hydroxyl Groups by Catalytic Hydrogenolysis

M. Gaunt, J. Spencer, Jinquan Yu, 1998 .

Stereoselective Deoxygenation of myo-Inositol Monotosylates with Lithium Triethylborohydride

J. Spencer, Jinquan Yu, 1996 .

Stereospecific deoxygenation of phosphine oxides with retention of configuration using triphenylphosphine or triethyl phosphite as an oxygen acceptor.

Hai‐Chen Wu, J. Spencer, Jinquan Yu, 2004, Organic letters.

Stereochemical uniformity in marine polyether ladders--implications for the biosynthesis and structure of maitotoxin.

A. Gallimore, J. Spencer, 2006, Angewandte Chemie.

Evidence for the role of the monB genes in polyether ring formation during monensin biosynthesis.

P. Leadlay, J. Staunton, V. Bolanos-Garcia, 2006, Chemistry & biology.

Intermediates in monensin biosynthesis: A late step in biosynthesis of the polyether ionophore monensin is crucial for the integrity of cation binding

P. Leadlay, Wolfgang Hüttel, J. Spencer, 2014, Beilstein journal of organic chemistry.

Stereochemical Uniformity in Marine Polyether Ladders — Implications for the Biosynthesis and Structure of Maitotoxin

A. Gallimore, J. Spencer, 2006 .

Accumulation of an E,E,E-triene by the monensin-producing polyketide synthase when oxidative cyclization is blocked.

James Staunton, P. Leadlay, J. Staunton, 2005, Angewandte Chemie.

P. Bhogal, J. Spencer, P. Shoolingin‐Jordan, 1996, Biochemistry.

A method for trapping intermediates of polyketide biosynthesis with a nonhydrolyzable malonyl-coenzyme A analogue.

D. Spiteller, Claire L Waterman, J. Spencer, 2005, Angewandte Chemie.

Synthetic Chain Terminators Off‐Load Intermediates from a Type I Polyketide Synthase

P. Leadlay, Elaine Stephens, L. Betancor, 2010, Chembiochem : a European journal of chemical biology.

Identification of a Pentaketide Stilbene Produced by a Type III Polyketide Synthase from Pinus sylvestris and Characterisation of Free Coenzyme A Intermediates

Tsung-Lin Li, D. Spiteller, J. Spencer, 2009, Chembiochem : a European journal of chemical biology.

The synthesis of chiral malonates and the determination of their chirality using fatty acid synthase and mass spectrometry

P. Jordan, J. Spencer, D. Corina, 1986 .

Mechanism of the Ring Contraction Step in Vitamin B12 Biosynthesis: The Origin and Subsequent Fate of the Oxygen Functionalities in Precorrin-3x

M. Kajiwara, A. Scott, P. J. Santander, 1994 .

Characterization of the enzyme BtrD from Bacillus circulans and revision of its functional assignment in the biosynthesis of butirosin.

A. Truman, F. Huang, J. Spencer, 2007, Angewandte Chemie.

High-throughput mutagenesis to evaluate models of stereochemical control in ketoreductase domains from the erythromycin polyketide synthase.

P. Leadlay, A. Baerga-Ortiz, H. O’Hare, 2006, Chemistry & biology.

Biosynthesis of the vancomycin group of antibiotics: characterisation of a type III polyketide synthase in the pathway to (S)-3,5-dihydroxyphenylglycine.

D. Williams, H. Hong, O. W. Choroba, 2001, Chemical communications.

Evidence that a Novel Thioesterase is Responsible for Polyketide Chain Release during Biosynthesis of the Polyether Ionophore Monensin

Wolfgang Kroutil, James Staunton, Hui Hong, 2006, Chembiochem : a European journal of chemical biology.

Purification and properties of 6-methylsalicylic acid synthase from Penicillium patulum.

P. Jordan, J. Spencer, 1992, The Biochemical journal.

Glyceryl‐S‐Acyl Carrier Protein as an Intermediate in the Biosynthesis of Tetronate Antibiotics

Hui Hong, P. Leadlay, Yuhui Sun, 2008, Chembiochem : a European journal of chemical biology.

Biosynthesis of 2-Deoxystreptamine-Containing Aminoglycoside Antibiotics

J. Spencer, Nicholas M. Llewellyn, 2007 .

Elaboration of Neosamine Rings in the Biosynthesis of Neomycin and Butirosin

N. Koorbanally, D. Spiteller, F. Huang, 2007, Chembiochem : a European journal of chemical biology.

The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: characterisation of an aminotransferase involved in the formation of 2-deoxystreptamine.

T. Mironenko, S. Haydock, D. Spiteller, 2005, Organic & biomolecular chemistry.

Chemoenzymatic acylation of aminoglycoside antibiotics.

J. Spencer, Nicholas M. Llewellyn, 2008, Chemical communications.

Combined Chemical‐Enzymatic Assembly of Aminoglycoside Derivatives with N‐1‐AHB Side Chain

T. Baasov, Igor Nudelman, Marina Cherniavsky, 2008 .

The neomycin biosynthetic gene cluster of Streptomyces fradiae NCIMB 8233: genetic and biochemical evidence for the roles of two glycosyltransferases and a deacetylase.

P. Leadlay, F. Huang, J. Spencer, 2008, Organic & biomolecular chemistry.

Biosynthesis of the unique amino acid side chain of butirosin: possible protective-group chemistry in an acyl carrier protein-mediated pathway.

R. Giri, F. Huang, Yanyan Li, 2005, Chemistry & biology.

Biosynthetic gene cluster of the glycopeptide antibiotic teicoplanin: characterization of two glycosyltransferases and the key acyltransferase.

P. Leadlay, T. Mironenko, S. Haydock, 2004, Chemistry & biology.

Characterisation of a hydroxymandelate oxidase involved in the biosynthesis of two unusual amino acids occurring in the vancomycin group of antibiotics.

D. Williams, A. Sandercock, O. W. Choroba, 2001, Chemical communications.

Gene dissection demonstrates that the Escherichia coli cysG gene encodes a multifunctional protein.

M. Warren, S. Woodcock, C. Roessner, 1994, The Biochemical journal.

Biosynthesis of vitamin B12: ring contraction is preceded by incorporation of molecular oxygen into precorrin-3

C. Roessner, A. Scott, N. Stolowich, 1993 .

Structural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlK

T. Blundell, P. Leadlay, D. Chirgadze, 2010, The Journal of Biological Chemistry.

A Novel Mycolactone from a Clinical Isolate of Mycobacterium ulcerans Provides Evidence for Additional Toxin Heterogeneity as a Result of Specific Changes in the Modular Polyketide Synthase

Hui Hong, P. Leadlay, T. Stinear, 2005, Chembiochem : a European journal of chemical biology.

Spectroscopic and electronic structure studies of aromatic electrophilic attack and hydrogen-atom abstraction by non-heme iron enzymes

E. Solomon, F. Huang, A. Decker, 2006, Proceedings of the National Academy of Sciences.

The Escherichia coli cysG gene encodes the multifunctional protein, siroheme synthase

C. Roessner, A. Scott, J. B. Spencer, 1993, FEBS letters.

Identification using LC-MSn of co-metabolites in the biosynthesis of the polyketide toxin mycolactone by a clinical isolate of Mycobacterium ulcerans.

Hui Hong, P. Leadlay, S. Cole, 2003, Chemical communications.

Possible origin of electronic effects in Rh(I)-catalyzed enantioselective hydrogenation.

S. A. Hamid, Hai‐Chen Wu, J. Spencer, 2009, Journal of the American Chemical Society.

Biosynthesis of the Vancomycin Group of Antibiotics: Involvement of an Unusual Dioxygenase in the Pathway to (S)-4-Hydroxyphenylglycine

and P H Williams, O. W. Choroba, J. Spencer, 2000 .

Conversion of hydroxyphenylpyruvate dioxygenases into hydroxymandelate synthases by directed evolution

Andrew N. Holding, H. O’Hare, F. Huang, 2006, FEBS letters.

Spectroscopic and electronic structure studies of the role of active site interactions in the decarboxylation reaction of alpha-keto acid-dependent dioxygenases.

E. Solomon, J. B. Spencer, M. Kavana, 2006, Journal of inorganic biochemistry.

Biosynthesis of vitamin B12

C. Roessner, A. Scott, N. Stolowich, 1993, FEBS letters.

Overexpression in Escherichia coli of 12 vitamin B12 biosynthetic enzymes.

B. Atshaves, C. Roessner, A. Scott, 1995, Protein expression and purification.

Isolation, structure, and genetically engineered synthesis of precorrin-5, the pentamethylated intermediate of vitamin B12 biosynthesis

B. Atshaves, C. Roessner, A. Scott, 1993 .

Genetically engineered synthesis of precorrin-6x and the complete corrinoid, hydrogenobyrinic acid, an advanced precursor of vitamin B12.

C. Roessner, A. Scott, P. J. Santander, 1994, Chemistry & biology.

The Hyperfine Coupling Constants and Rates of Exchange for C13N- with the Axial and Equatorial Positions in Cr(CN)5-NO-3

R. J. Myers, J. Spencer, 1964 .

Analysis of the Tetronomycin Gene Cluster: Insights into the Biosynthesis of a Polyether Tetronate Antibiotic

Hui Hong, P. Leadlay, Yuhui Sun, 2008, Chembiochem : a European journal of chemical biology.

Absolute Stereochemistry of Precorrin-3x and Its Relevance to the Dichotomy of Ring Contraction Mechanism in Vitamin B12 Biosynthesis

Jianji Wang, A. Scott, P. J. Santander, 1996 .

Biosynthesis of vitamin B12

C. Roessner, A. Scott, J. B. Spencer, 1993, FEBS letters.

Covalent Linkage Mediates Communication between ACP and TE Domains in Modular Polyketide Synthases

P. Leadlay, K. Weissman, M. Tosin, 2008, Chembiochem : a European journal of chemical biology.

Chemoenzymatic acylation of aminoglycoside antibiotics.

J. Spencer, Nicholas M. Llewellyn, 2008, Chemical communications.

Chimeric glycosyltransferases for the generation of hybrid glycopeptides.

T. Blundell, A. Truman, M. Dias, 2009, Chemistry & biology.