Catherine K J Chen

Getting to the core of platinum drug bio-distributions: the penetration of anti-cancer platinum complexes into spheroid tumour models.

Nicole S. Bryce, M. D. de Jonge, D. Howard, 2012, Metallomics : integrated biometal science.

The effect of charge on the uptake and resistance to reduction of platinum(IV) complexes in human serum and whole blood models.

T. Hambley, P. Kappen, A. Renfrew, 2020, Metallomics : integrated biometal science.

Structural and anticancer properties of hydrogen bonded diphenyl phosphate adducts of Pt(IV) complexes: the importance of pKa matching.

T. Hambley, G. Deacon, T. Failes, 2012, Journal of inorganic biochemistry.

Influence of equatorial and axial carboxylato ligands on the kinetic inertness of platinum(IV) complexes in the presence of ascorbate and cysteine and within DLD-1 cancer cells.

T. Hambley, Jenny Z. Zhang, J. Aitken, 2013, Journal of medicinal chemistry.

The reduction of cis-platinum(iv) complexes by ascorbate and in whole human blood models using 1H NMR and XANES spectroscopy.

T. Hambley, P. Kappen, Catherine K J Chen, 2019, Metallomics : integrated biometal science.

trans-Platinum(iv) pro-drugs that exhibit unusual resistance to reduction by endogenous reductants and blood serum but are rapidly activated inside cells: 1H NMR and XANES spectroscopy study.

T. Hambley, D. Gibson, P. Kappen, 2020, Dalton transactions.

The impact of highly electron withdrawing carboxylato ligands on the stability and activity of platinum(IV) pro-drugs

T. Hambley, Catherine K J Chen, 2019, Inorganica Chimica Acta.