Liesbet Geris

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Mathematical modeling in regenerative medicine: from bench to bedside

Liesbet Geris, 2017 .

Model-guided bone tissue engineering: from bench to bedside via in silico modeling

Liesbet Geris, 2014 .

A Boolean network approach to developmental engineering

Liesbet Geris, Hans Van Oosterwyck, Johan Kerkhofs, 2011 .

Tissue engineering: from mechanisms to therapy via mathematical modeling

Liesbet Geris, 2011 .

Bringing computational models of bone regeneration to the clinic

Liesbet Geris, Aurélie Carlier, Johan Lammens, 2015, Wiley interdisciplinary reviews. Systems biology and medicine.

A mechano-regulatory model for bone healing predictions under the influence of ultrasound

Dimitrios I. Fotiadis, Liesbet Geris, Hans Van Oosterwyck, 2015, 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC).

An Introduction to Uncertainty in the Development of Computational Models of Biological Processes

Liesbet Geris, David Gomez-Cabrero, L. Geris, 2016 .

UvA-DARE (Digital Academic Repository) Virtual physiological human 2016: translating the virtual physiological human to the clinic

Liesbet Geris, Alfons G. Hoekstra, Maria Siebes, 2022 .

In silico regenerative medicine: how computational tools allow addressing challenges in a volatile market.

Liesbet Geris, 2016 .

Linking decoupled bioprocess design to tissue-engineered construct quality attributes: a stairway to robust manufacturing

Liesbet Geris, Frank Luyten, Jan Schrooten, 2013 .

The Virtual Physiological Human

Liesbet Geris, L. Geris, 2020 .

Computational Bone Tissue Engineering: Virtual Models for Living Implants

Liesbet Geris, 2018 .

A Dynamic Graph Model of Endochondral Ossification can assess the Importance of Biological Actors in Differentiation

Liesbet Geris, Hans Van Oosterwyck, Johan Kerkhofs, 2012 .

MAXIMIZING NEOTISSUE GROWTH IN A PERFUSION BIOREACTOR USING BAYESIAN OPTIMIZATION

Liesbet Geris, Mohammad Mehrian, Ioannis Papantoniou, 2017 .

In silico methods - Computational alternatives to animal testing.

Liesbet Geris, Susanna Röblitz, Andrea Volkamer, 2018, ALTEX.

Immersed Boundary Models for Quantifying Flow-Induced Mechanical Stimuli on Stem Cells Seeded on 3D Scaffolds in Perfusion Bioreactors

Liesbet Geris, Bart Smeets, Frank P. Luyten, 2016, PLoS Comput. Biol..

A Multiphysics model of neotissue growth in a perfu sion bioreactor

Liesbet Geris, Jan Schrooten, Ioannis Papantoniou, 2014 .

The future is digital: In silico tissue engineering

Liesbet Geris, Aurélie Carlier, Ioannis Papantoniou, 2018, Current Opinion in Biomedical Engineering.

Optimization of contrast enhanced Ct for neo-tissue quantification using a design of experiment approach

Liesbet Geris, Jan Schrooten, Frank Luyten, 2015 .

The Third Era of Tissue Engineering: Reversing the Innovation Drivers.

Liesbet Geris, Ioannis Papantoniou, I. Papantoniou, 2019, Tissue engineering. Part A.

Computational bone tissue engineering

Liesbet Geris, 2017 .

Verifying and Validating Quantitative Systems Pharmacology and In Silico Models in Drug Development: Current Needs, Gaps, and Challenges

Liesbet Geris, Jean-Pierre Boissel, Flora T Musuamba, 2020, CPT: pharmacometrics & systems pharmacology.

A Boolean network model of the growth plate

Liesbet Geris, Hans Van Oosterwyck, Johan Kerkhofs, 2010 .

Optimizing neotissue growth inside perfusion bioreactors with respect to culture and labor cost: a multi-objective optimization study using evolutionary algorithms

Liesbet Geris, Mohammad Mehrian, L. Geris, 2020, Computer methods in biomechanics and biomedical engineering.

Replicating Endochondral Processes Through the Induction and Control of Periosteal Cell Differentiation.

Liesbet Geris, Frank Luyten, Luis Freitas Mendes, 2013 .

In silico powers for smarter regeneration

Liesbet Geris, 2017 .

Lessons from the Growth Plate: Computational Modelling of Chondrogenic Differentiation

Liesbet Geris, Johan Kerkhofs, Frank Luyten, 2016 .

Optimizing The Micro-Environment In A Tissue Engineering Scaffold: A Computational Approach

Liesbet Geris, Maarten Moesen, Hans Van Oosterwyck, 2010 .

Computational Modeling Under Uncertainty: Challenges and Opportunities

Liesbet Geris, David Gomez-Cabrero, Jesper Tegnér, 2016 .

A visco-elastic model for the prediction of orthodontic tooth movement

Liesbet Geris, An Van Schepdael, Kris De Bondt, 2014, Computer methods in biomechanics and biomedical engineering.

Bayesian Multiobjective Optimisation With Mixed Analytical and Black-Box Functions: Application to Tissue Engineering

Liesbet Geris, Marc Peter Deisenroth, Ruth Misener, 2019, IEEE Transactions on Biomedical Engineering.

To heal or not to heal: designing successful bone tissue engineering strategies with a multiscale bioregulatory model

Liesbet Geris, Hans Van Oosterwyck, Aurélie Carlier, 2014 .

A novel mathematical model to simulate and predict tissue regeneration

Jos Vander Sloten, Liesbet Geris, Hans Van Oosterwyck, 2006 .

In Vivo, In Vitro, In Silico: Computational Tools for Product and Process Design in Tissue Engineering

Liesbet Geris, L. Geris, 2012 .

MOSAIC: A Multiscale Model of Osteogenesis and Sprouting Angiogenesis with Lateral Inhibition of Endothelial Cells

Liesbet Geris, Hans Van Oosterwyck, Katie Bentley, 2012, PLoS Comput. Biol..

Improving Perfusion Bioreactor Yields by Using Particle Swarm Optimization

Liesbet Geris, Mohammad Mehrian, Ioannis Papantoniou, 2016 .

NanoCT and contrast-enhanced nanoCT as first line screening and quality control tools for robust production of tissue engineered products: an overview

Liesbet Geris, Frank Luyten, Greet Kerckhofs, 2015 .

Effect of ultrasound on bone fracture healing: A computational bioregulatory model

Dimitrios I. Fotiadis, Liesbet Geris, Hans Van Oosterwyck, 2018, Comput. Biol. Medicine.

Sensitivity Analysis by Design of Experiments

Liesbet Geris, Aurélie Carlier, An Van Schepdael, 2016 .

Product and Process Design: Toward Industrial TE Manufacturing

Liesbet Geris, Athanasios Mantalaris, Jean-Marie Aerts, 2014 .

A modular, standalone perfusion bioreactor for robust, monitored and controlled tissue engineering

Liesbet Geris, Ioannis Papantoniou, Toon Lambrechts, 2018 .

Determining optimum parameter bounds for a model of Wnt, BMP and ERK Crosstalk during Osteochondrogenic Differentiation using Genetic Algorithms

Liesbet Geris, Mohammad Mehrian, Morgan Germain, 2015 .

Computational tools for biomaterial design: from reverse engineering to mechanistic modeling

Liesbet Geris, 2018 .

Bayesian Multi-Objective Optimisation of Neotissue Growth in a Perfusion Bioreactor Set-up

Liesbet Geris, Roberto Calandra, Simon Olofsson, 2017 .

Mathematical modeling of fracture healing in mice: comparison between experimental data and numerical simulation results

Rüdiger Weiner, Jos Vander Sloten, Liesbet Geris, 2006, Medical and Biological Engineering and Computing.

Computational modeling of bone fracture non-unions: four clinically relevant case studies

Liesbet Geris, Aurélie Carlier, Johan Lammens, 2015, In silico cell and tissue science.

Incorporating Quality In Engineered Tissues Using Bottom-Up Niche Assemblies

Liesbet Geris, Frank Luyten, Ioannis Papantoniou, 2017 .

A Semiquantitative Framework for Gene Regulatory Networks: Increasing the Time and Quantitative Resolution of Boolean Networks

Liesbet Geris, Johan Kerkhofs, L. Geris, 2015, PloS one.

Streamlining cell therapy manufacturing: Automated production and integrated data management

Jean-Marie Aerts, Liesbet Geris, Ioannis Papantoniou, 2019 .

Multi-objective optimization of cost-efficient neotissue growth inside 3D scaffolds using evolutionary algorithms

Liesbet Geris, Ruth Misener, Simon Olofsson, 2018 .

A reduced model developed for describing neotissue growth during dynamic bioreactor culture

Liesbet Geris, Mohammad Mehrian, Yann Guyot, 2015 .

Computational modeling in tissue engineering

Liesbet Geris, L. Geris, 2013 .

Mechanobiology of bone regeneration and bone adaptation to achieve stable long-term fixation of endosseous implants

Jos Vander Sloten, Liesbet Geris, Ignace Naert, 2005 .

Model-Based Optimization of the Medium Refreshment Regime During Neotissue Growth in a Perfusion Bioreactor

Liesbet Geris, Mohammad Mehrian, Yann Guyot, 2017 .

Materiomics: Computational analysis of high-throughput material screens

Marcel J. T. Reinders, Liesbet Geris, Marc Hulsman, 2013 .

In silico models for regenerative medicine: hype or help?

Liesbet Geris, 2013 .

Digital twins in tissue engineering: from bench to bedside via the computer.

Liesbet Geris, 2019 .

Size Does Matter: An Integrative In Vivo-In Silico Approach for the Treatment of Critical Size Bone Defects

Liesbet Geris, Hans Van Oosterwyck, Aurélie Carlier, 2014, PLoS Comput. Biol..

A single cell-based modelling framework for bone tissue engineering

Liesbet Geris, Bart Smeets, Herman Ramon, 2010 .

Computational bone tissue engineering: from carriers and culture to clinics

Liesbet Geris, 2015 .

Turning Nature’s own processes into design strategies for living bone implant biomanufacturing: a decade of Developmental Engineering

Liesbet Geris, Ioannis Papantoniou, Gabriella Nilsson Hall, 2020, Advanced drug delivery reviews.

Serum- and scaffold-free technology for in vivo bone and cartilage formation using human periosteum-derived cells

Liesbet Geris, Luis Freitas Mendes, Yoke Chin Chai, 2015 .

Developing scaffold free constructs for bone and cartilage tissue engineering through optimization of culture conditions for human periosteum-derived cells

Liesbet Geris, Luis Freitas Mendes, Yoke Chin Chai, 2015 .

Contrast enhanced nanoCT parameter optimisation for volumetric analyses of in vitro manufactured tissue-engineered bone constructs

Liesbet Geris, Frank Luyten, Jan Schrooten, 2014 .

Computational design of tissue engineering scaffolds

Liesbet Geris, Esther Reina-Romo, Ioannis Papantoniou, 2019, Handbook of Tissue Engineering Scaffolds: Volume One.

Occurrence and Treatment of Bone Atrophic Non-Unions Investigated by an Integrative Approach

Jos Vander Sloten, Liesbet Geris, Hans Van Oosterwyck, 2010, PLoS Comput. Biol..

Cancer modeling: From mechanistic to data-driven approaches, and from fundamental insights to clinical applications

Liesbet Geris, Sophie Bekisz, L. Geris, 2020, J. Comput. Sci..

Threats and Opportunities for the Clinical Investigation of High-risk Medical Devices in the Context of the New European Regulations

Nicos Maglaveras, Lionel Pazart, Liesbet Geris, 2021, BIODEVICES.

An open source crash course on parameter estimation of computational models using a Bayesian optimization approach

Mojtaba Barzegari, Liesbet Geris, 2021, Journal of Open Source Education.

Possible Contexts of Use for In Silico Trials Methodologies: A Consensus-Based Review

Simon J. Sonntag, Marco Viceconti, Michael Neidlin, 2021, IEEE Journal of Biomedical and Health Informatics.

Reproducible research in computational sciences: A use case for uncertainty quantification using Jupyter Notebooks

Mojtaba Barzegari, Liesbet Geris, 2021, KU Leuven Open Science Day.

Computational modeling of degradation process of biodegradable magnesium biomaterials pdf

Mojtaba Barzegari, Liesbet Geris, Sviatlana V. Lamaka, 2021, ArXiv.

Computational Modeling and Reverse Engineering to Reveal Dominant Regulatory Interactions Controlling Osteochondral Differentiation: Potential for Regenerative Medicine

Liesbet Geris, Johan Kerkhofs, Raphaelle Lesage, 2018, Front. Bioeng. Biotechnol..

Towards Self-Regulated Bioprocessing: A Compact Benchtop Bioreactor System for Monitored and Controlled 3D Cell and Tissue Culture.

Liesbet Geris, Ioannis Papantoniou, Frank P Luyten, 2019, Biotechnology journal.

Contrast-Enhanced Nanofocus X-Ray Computed Tomography Allows Virtual Three-Dimensional Histopathology and Morphometric Analysis of Osteoarthritis in Small Animal Models

Martine Wevers, Liesbet Geris, Jan Schrooten, 2014, Cartilage.

Uncertainty in biology: a computational modeling approach

Liesbet Geris, David Gomez-Cabrero, L. Geris, 2015 .

Simultaneous 3D visualization and quantification of the bone marrow adiposity and vascularity using novel contrast agents for contrast-enhanced computed tomography

Liesbet Geris, Frank Luyten, Tatjana N. Parac-Vogt, 2016 .

Oxygen as a critical determinant of bone fracture healing-a multiscale model.

Liesbet Geris, Aurélie Carlier, Hans Van Oosterwyck, 2015, Journal of theoretical biology.

Application of mechanoregulatory models to simulate peri-implant tissue formation in an in vivo bone chamber.

Liesbet Geris, Ignace Naert, Joke Duyck, 2008, Journal of biomechanics.

Multifactorial Optimization of Contrast-Enhanced Nanofocus Computed Tomography for Quantitative Analysis of Neo-Tissue Formation in Tissue Engineering Constructs

Liesbet Geris, Frank P. Luyten, Peter Dubruel, 2015, PloS one.

Relating the Chondrocyte Gene Network to Growth Plate Morphology: From Genes to Phenotype

Liesbet Geris, Frank P. Luyten, Johan Kerkhofs, 2012, PloS one.

Maximizing neotissue growth kinetics in a perfusion bioreactor: An in silico strategy using model reduction and Bayesian optimization

Liesbet Geris, Ruth Misener, Simon Olofsson, 2018, Biotechnology and bioengineering.

Mathematical Modeling in Wound Healing, Bone Regeneration and Tissue Engineering

Liesbet Geris, Alf Gerisch, L. Geris, 2010, Acta biotheoretica.

Angiogenesis in bone fracture healing: a bioregulatory model.

Rüdiger Weiner, Jos Vander Sloten, Liesbet Geris, 2008, Journal of theoretical biology.

Regenerative orthopaedics: in vitro, in vivo … in silico

Liesbet Geris, L. Geris, 2014, International Orthopaedics.

Simultaneous three-dimensional visualization of mineralized and soft skeletal tissues by a novel microCT contrast agent with polyoxometalate structure.

Liesbet Geris, Frank P Luyten, Greet Kerckhofs, 2018, Biomaterials.

A cell based modelling framework for skeletal tissue engineering applications.

Liesbet Geris, Bart Smeets, Herman Ramon, 2010, Journal of biomechanics.

Mechanical loading affects angiogenesis and osteogenesis in an in vivo bone chamber: a modeling study.

Liesbet Geris, Ignace Naert, Joke Duyck, 2010, Tissue engineering. Part A.

Predicting in vitro human mesenchymal stromal cell expansion based on individual donor characteristics using machine learning.

Liesbet Geris, Frank P. Luyten, Mohammad Mehrian, 2020, Cytotherapy.

Mathematical Modelling of Cell Adhesion in Tissue Engineering using Continuum Models

Liesbet Geris, Alf Gerisch, 2010 .

Towards a quantitative understanding of oxygen tension and cell density evolution in fibrin hydrogels.

Liesbet Geris, Jan Schrooten, Jan Demol, 2011, Biomaterials.

Uncertainty in Biology

Liesbet Geris, David Gomez-Cabrero, 2016 .

Different mechanoregulatory models predict different patterns of tissue differentiation

Liesbet Geris, Ignace Naert, Hans Van Oosterwyck, 2005 .

Numerical simulation of two-dimensional and three-dimensional axisymmetric advection–diffusion systems with complex geometries using finite-volume methods

Liesbet Geris, Alf Gerisch, J. M. A. Ashbourn, 2010, Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences.

The combined bone forming capacity of human periosteal derived cells and calcium phosphates.

Liesbet Geris, Jan Schrooten, Frank P Luyten, 2011, Biomaterials.

A hybrid bioregulatory model of angiogenesis during bone fracture healing

Liesbet Geris, Dirk Vandepitte, Alf Gerisch, 2011, Biomechanics and modeling in mechanobiology.

Potential treatment strategies for atrophic non-unions

Jos Vander Sloten, Liesbet Geris, Hans Van Oosterwyck, 2009 .

Mathematical modeling of bone regeneration including the angiogenic process

Liesbet Geris, J. Vander Sloten, H. Van Oosterwyck, 2006 .