Tomoharu Kuboyama

发表

Trigonelline recovers memory function in Alzheimer’s disease model mice: evidence of brain penetration and target molecule

Ximeng Yang, C. Tohda, M. Farid, 2020, Scientific Reports.

GRP78-Mediated Signaling Contributes to Axonal Growth Resulting in Motor Function Recovery in Spinal Cord-Injured Mice

C. Tohda, Tomoharu Kuboyama, Y. Tanie, 2020, Frontiers in Pharmacology.

Naringenin promotes microglial M2 polarization and Aβ degradation enzyme expression

C. Tohda, Zhiyou Yang, Tomoharu Kuboyama, 2019, Phytotherapy research : PTR.

[Development of New Therapies for Neurodegenerative Diseases via Axonal Growth].

Tomoharu Kuboyama, 2019, Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan.

Neuritic regeneration and synaptic reconstruction induced by withanolide A

K. Komatsu, C. Tohda, Tomoharu Kuboyama, 2005, British journal of pharmacology.

A Novel Rac1-GSPT1 Signaling Pathway Controls Astrogliosis Following Central Nervous System Injury*

D. Gutmann, A. Aiba, N. Saito, 2016, The Journal of Biological Chemistry.

Metabolite 1 of Protopanaxadiol-Type Saponins, an Axonal Regenerative Factor, Stimulates Teneurin-2 Linked by PI3-Kinase Cascade

K. Komatsu, C. Tohda, Tomoharu Kuboyama, 2006, Neuropsychopharmacology.

Shati/Nat8l Overexpression Improves Cognitive Decline by Upregulating Neuronal Trophic Factor in Alzheimer’s Disease Model Mice

S. Muramatsu, C. Tohda, Naotaka Izuo, 2022, Neurochemical Research.

Recovery from spinal cord injury via M2 microglial polarization induced by Polygalae Radix.

C. Tohda, Tomoharu Kuboyama, Seiya Kominato, 2020, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Cistanche tubulosa (Schenk) Wight Extract Enhances Hindlimb Performance and Attenuates Myosin Heavy Chain IId/IIx Expression in Cast-Immobilized Mice

C. Tohda, Y. Shimada, Yoshiyuki Kimbara, 2019, Evidence-based complementary and alternative medicine : eCAM.

Search for Natural Products Related to Regeneration of the Neuronal Network

Katsuko Komatsu, K. Komatsu, C. Tohda, 2005, Neurosignals.

Withanolide derivatives from the roots of Withania somnifera and their neurite outgrowth activities.

N. Nakamura, M. Hattori, Jing Zhao, 2002, Chemical & pharmaceutical bulletin.

Effects of Ashwagandha (roots of Withania somnifera) on neurodegenerative diseases.

K. Komatsu, C. Tohda, Tomoharu Kuboyama, 2014, Biological & pharmaceutical bulletin.

Active Constituents from Drynaria fortunei Rhizomes on the Attenuation of Aβ(25-35)-Induced Axonal Atrophy.

C. Tohda, Chihiro Tohda, Katsuhiro Konno, 2015, Journal of natural products.

Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha

N. Nakamura, M. Hattori, Jing Zhao, 2002, Neuroreport.

Matrine promotes neural circuit remodeling to regulate motor function in a mouse model of chronic spinal cord injury

C. Tohda, Tomoharu Kuboyama, Norio Tanabe, 2019, Neural regeneration research.

The Extract of Roots of Sophora flavescens Enhances the Recovery of Motor Function by Axonal Growth in Mice with a Spinal Cord Injury

C. Tohda, K. Konno, Kohei Kazuma, 2016, Front. Pharmacol..

HDAC3 inhibition ameliorates spinal cord injury by immunomodulation

Xiaoping Zhou, Hongyan Zou, R. Friedel, 2017, Scientific Reports.

A Systematic Strategy for Discovering a Therapeutic Drug for Alzheimer’s Disease and Its Target Molecule

C. Tohda, Zhiyou Yang, Tomoharu Kuboyama, 2017, Front. Pharmacol..

Current and future therapeutic strategies for functional repair of spinal cord injury.

C. Tohda, Tomoharu Kuboyama, 2011, Pharmacology & therapeutics.

New reliable scoring system, Toyama mouse score, to evaluate locomotor function following spinal cord injury in mice

C. Tohda, Tomoharu Kuboyama, Michiko Shigyo, 2014, BMC Research Notes.

Withanoside IV and its active metabolite, sominone, attenuate Aβ(25–35)‐induced neurodegeneration

Katsuko Komatsu, K. Komatsu, C. Tohda, 2006, The European journal of neuroscience.

Polygalae Radix Extract Prevents Axonal Degeneration and Memory Deficits in a Transgenic Mouse Model of Alzheimer’s Disease

C. Tohda, Hiroo Yamasaki, Keisuke Hirotsu, 2017, Front. Pharmacol..

Diosgenin is an exogenous activator of 1,25D3-MARRS/Pdia3/ERp57 and improves Alzheimer's disease pathologies in 5XFAD mice

I. Nemere, C. Tohda, T. Urano, 2012, Scientific Reports.

Extracellular vimentin interacts with insulin-like growth factor 1 receptor to promote axonal growth

C. Tohda, Masahito Tada-Umezaki, Tomoharu Kuboyama, 2015, Scientific Reports.

Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage

C. Tohda, Tomoharu Kuboyama, Young-Ae Lee, 2015, Neurobiology of Aging.

Natural Medicines and Their Underlying Mechanisms of Prevention and Recovery from Amyloid Β-Induced Axonal Degeneration in Alzheimer’s Disease

Ximeng Yang, C. Tohda, Tomoharu Kuboyama, 2020, International journal of molecular sciences.

A novel compound, denosomin, ameliorates spinal cord injury via axonal growth associated with astrocyte‐secreted vimentin

C. Tohda, Kenji Sugimoto, K. Teshigawara, 2013, British journal of pharmacology.

Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnifera) in SK‐N‐SH cells

K. Komatsu, C. Tohda, Tomoharu Kuboyama, 2000, Neuroreport.

Kamikihi-to (KKT) Rescues Axonal and Synaptic Degeneration Associated with Memory Impairment in a Mouse Model of Alzheimer's Disease, 5XFAD

C. Tohda, Rie Nakada, T. Urano, 2011, The International journal of neuroscience.

Comparing the Effects of Kamikihito in Japan and Kami‐Guibi‐Tang in Korea on Memory Enhancement: Working Towards the Development of a Global Study

W. Jung, Ki-Ho Cho, C. Tohda, 2015, Phytotherapy research : PTR.

Scientific basis for the anti-dementia drugs of constituents from Ashwagandha (Withania somnifera)(Chemical & Pharmacological study)

K. Komatsu, C. Tohda, Tomoharu Kuboyama, 2005 .

Extracellular Neuroleukin Enhances Neuroleukin Secretion From Astrocytes and Promotes Axonal Growth in vitro and in vivo

C. Tohda, Tomoharu Kuboyama, Y. Tanie, 2018, Front. Pharmacol..

Paxillin phosphorylation counteracts proteoglycan-mediated inhibition of axon regeneration

J. Bixby, H. Kamiguchi, V. Lemmon, 2013, Experimental Neurology.

Matrine Directly Activates Extracellular Heat Shock Protein 90, Resulting in Axonal Growth and Functional Recovery in Spinal Cord Injured-Mice

C. Tohda, Tomoharu Kuboyama, Norio Tanabe, 2018, Front. Pharmacol..

Quality assessment of Rheum species cultivated in Japan by focusing on M2 polarization of microglia

K. Komatsu, Kazufumi Toume, Tomoharu Kuboyama, 2023, Journal of Natural Medicines.

Combined Treatment with Two Water Extracts of Eleutherococcus senticosus Leaf and Rhizome of Drynaria fortunei Enhances Cognitive Function: A Placebo-Controlled, Randomized, Double-Blind Study in Healthy Adults

M. Matsui, Ximeng Yang, C. Tohda, 2020, Nutrients.

Memory Enhancement by Oral Administration of Extract of Eleutherococcus senticosus Leaves and Active Compounds Transferred in the Brain

K. Yoshimatsu, Ximeng Yang, C. Tohda, 2019, Nutrients.