Kevin Chen

发表

Novel monoamine oxidase A knock out mice with human-like spontaneous mutation

J. Shih, M. Bortolato, A. Scott, 2008, Neuroreport.

Striatal Damage and Oxidative Stress Induced by the Mitochondrial Toxin Malonate Are Reduced in Clorgyline-Treated Rats and MAO-A Deficient Mice

D. Butterfield, K. Young, J. Shih, 2004, Neurochemical Research.

Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice

O. Scremin, J. Shih, D. Holschneider, 1999, Brain Research.

Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A

M. Kung, J. Shih, I. Seif, 1999, Brain Research.

Molecular Studies of 5‐HT Receptors a

J. Shih, Kevin Chen, 1990, Annals of the New York Academy of Sciences.

Monoamine Oxidase A–Mediated Enhanced Catabolism of Norepinephrine Contributes to Adverse Remodeling and Pump Failure in Hearts With Pressure Overload

D. Kass, R. Blakely, K. Pacak, 2010, Circulation research.

Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts.

D. Kass, M. Lindsey, K. Pacak, 2014, Antioxidants & redox signaling.

R1, a Novel Repressor of the Human Monoamine Oxidase A*

S. Choi, X. Ou, J. Shih, 2005, Journal of Biological Chemistry.

Adverse Remodeling and Pump Failure in Hearts With Pressure Overload Mediated Enhanced Catabolism of Norepinephrine Contributes to − Monoamine Oxidase

D. Kass, R. Blakely, K. Pacak, 2009 .

Decreased Methylation and Transcription Repressor Sp3 Up-regulated Human Monoamine Oxidase (MAO) B Expression during Caco-2 Differentiation*

W. K. Wong, J. Shih, Kevin Chen, 2003, Journal of Biological Chemistry.

Transcription Factor E2F-Associated Phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and Simian Virus 40 Promoter Factor 1 (Sp1) Cooperatively Regulate Glucocorticoid Activation of Monoamine Oxidase B

X. Ou, J. Shih, J. Wu, 2011, Molecular Pharmacology.

Tissue Distribution of Human Monoamine Oxidase A and B mRNA

R. Neve, J. Shih, N. Lan, 1990, Journal of neurochemistry.

The Deduced Amino Acid Sequences of Human Platelet and Frontal Cortex Monoamine Oxidase B Are Identical

J. Shih, Kevin Chen, Hsiu‐Fei Wu, 1993, Journal of neurochemistry.

Different Organization of Human Monoamine Oxidase (Mao) A and B Promoters

J. Grimsby, Q. Zhu, Kevin Chen, 1993 .

Promoter Organization (MAO) A and B Genes and Activity of Human Monoamine Oxidase

J. Shih, J. Grimsby, Q. Zhu, 1992 .

In Vivo and in Vitro Functions of Two Types of Mao

J. Shih, Kevin Chen, 2002 .

Effects of Carboxyl-terminal Truncations on the Activity and Solubility of Human Monoamine Oxidase B*

J. Shih, I. Rebrin, Kevin Chen, 2001, The Journal of Biological Chemistry.

Striatal Dopamine Metabolism in Monoamine Oxidase B‐Deficient Mice : A Brain Dialysis Study

J. Shih, F. Fornai, F. Giorgi, 1999, Journal of neurochemistry.

Transcription factor binding to the core promoter of the human monoamine oxidase B gene in the cerebral cortex and in blood cells

J. Shih, L. Oreland, M. Damberg, 1998, Neuroscience Letters.

Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives

P. Gaspar, C. Alvarez, T. Vitalis, 2003, The Journal of comparative neurology.

Autoantibody profiling of monoamine oxidase A knockout mice, an autism spectrum disorder model

J. Shih, F. R. Sutandy, Guan-Da Syu, 2022, Brain, Behavior, and Immunity.

A Novel Role for Glyceraldehyde-3-Phosphate Dehydrogenase and Monoamine Oxidase B Cascade in Ethanol-Induced Cellular Damage

H. Meltzer, A. Sawa, M. Austin, 2010, Biological Psychiatry.

A novel role for GAPDH-MAO B cascade in ethanol-induced cellular damage

H. Meltzer, A. Sawa, M. Austin, 2010 .

Monoamine Oxidases Regulate Telencephalic Neural Progenitors in Late Embryonic and Early Postnatal Development

M. Mattson, J. Cadet, Kevin S. Chen, 2010, The Journal of Neuroscience.

Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice

Richard F. Thompson, J. Shih, Chanpreet Singh, 2013, Proceedings of the National Academy of Sciences.

Increased stress response and β–phenylethylamine in MAOB–deficient mice

Takeshi Kumazawa, M. Toth, J. Shih, 1997, Nature Genetics.

Forebrain-specific Expression of Monoamine Oxidase A Reduces Neurotransmitter Levels, Restores the Brain Structure, and Rescues Aggressive Behavior in Monoamine Oxidase A-deficient Mice*

J. Shih, I. Rebrin, I. Seif, 2007, Journal of Biological Chemistry.

Monoamine oxidase A and A/B knockout mice display autistic-like features.

Ryan D. Darling, R. Lin, C. Wellman, 2013, The international journal of neuropsychopharmacology.

Substrate and Inhibitor Specificities for Human Monoamine Oxidase A and B Are Influenced by a Single Amino Acid*

J. Shih, I. Rebrin, J C Shih, 2001, The Journal of Biological Chemistry.

Transcriptional regulation and multiple functions of MAO genes

J. Shih, J. Wu, Kevin Chen, 2011, Journal of Neural Transmission.

Monoamine oxidase inactivation: from pathophysiology to therapeutics.

J. Shih, M. Bortolato, Marco Bortolato, 2008, Advanced drug delivery reviews.

Molecular biology of serotonin (5-HT) receptors

J. Shih, T. Gallaher, Kevin Chen, 1991, Pharmacology Biochemistry and Behavior.

The Degradation of Serotonin: Role of MAO

J. Shih, M. Bortolato, Kevin Chen, 2010 .

Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli.

N. Hiroi, J. Shih, I. Seif, 2006, Human molecular genetics.

Altered gene expression in early postnatal monoamine oxidase A knockout mice

B. Tabakoff, J. Shih, S. Flink, 2017, Brain Research.

Monoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress

C. Wellman, J. Shih, M. Bortolato, 2015, The international journal of neuropsychopharmacology.

The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake.

Kevin S. Chen, J. Shih, M. Bortolato, 2014, Journal of psychiatric research.

Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice

M. Coba, J. Shih, M. Bortolato, 2013, Neuropharmacology.

Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice

Ryan D. Darling, N. Volkow, P. Thanos, 2012, Neuropharmacology.

NMDARs Mediate the Role of Monoamine Oxidase A in Pathological Aggression

A. Urbani, R. Frau, J. Shih, 2012, The Journal of Neuroscience.

Maladaptive defensive behaviours in monoamine oxidase A-deficient mice.

R. Frau, J. Shih, M. Bortolato, 2011, The international journal of neuropsychopharmacology.

Altered Expression of Tyrosine Hydroxylase in the Locus Coeruleus Noradrenergic System in Citalopram Neonatally Exposed Rats and Monoamine Oxidase A Knock Out Mice

Ryan D. Darling, R. Lin, J. Shih, 2011, Anatomical record.

Social Deficits and Perseverative Behaviors, but not Overt Aggression, in MAO-A Hypomorphic Mice

C. Wellman, J. Shih, M. Bortolato, 2011, Neuropsychopharmacology.

Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells

J. Shih, Qi-Long Ying, Ping Li, 2011, Journal of Neural Transmission.

Behavioral Disinhibition and Reduced Anxiety-like Behaviors in Monoamine Oxidase B-Deficient Mice

J. Shih, M. Bortolato, S. Godar, 2009, Neuropsychopharmacology.

Regulation of monoamine oxidase A by the SRY gene on the Y chromosome

Yun-Fai Chris Lau, J. Shih, J. Wu, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway.

X. Ou, J. Shih, Kevin Chen, 2006, Proceedings of the National Academy of Sciences of the United States of America.

J. Shih, C. Teng, Zhiping Zhang, 2006, Molecular endocrinology.

Serotonin Catabolism and the Formation and Fate of 5-Hydroxyindole Thiazolidine Carboxylic Acid*

J. Sweedler, N. Hatcher, Kevin S. Chen, 2006, Journal of Biological Chemistry.

The circadian rhythm of 5-HT biosynthetic and degradative enzymes in immortalized mouse neuroendocrine pineal cell line--a model for studying circadian rhythm.

Kevin S. Chen, J. Shih, Philip Yeung Lam, 2004, Life Science.

A Spontaneous Point Mutation Produces Monoamine Oxidase A/B Knock-out Mice with Greatly Elevated Monoamines and Anxiety-like Behavior*♦

J. Shih, D. Holschneider, I. Rebrin, 2004, Journal of Biological Chemistry.

Organization of MAO A and MAO B promoters and regulation of gene expression.

Kevin S. Chen, Kevin Chen, 2004, Neurotoxicology.

Biochemical effects of the monoamine neurotoxins DSP‐4 and MDMA in specific brain regions of MAO‐B‐deficient mice

Kevin S. Chen, J. Shih, F. Fornai, 2001, Synapse.

Phe208 and Ile199 in Human Monoamine Oxidase A and B Do Not Determine Substrate and Inhibitor Specificities as in Rat

J. Shih, Kevin Chen, R. M. Geha, 2000, Journal of neurochemistry.

Localization of monoamine oxidase A and B mRNA in the rat brain by in situ hybridization

T. Joh, J. Shih, J. Jahng, 1997, Synapse.

Glucocorticoid and Androgen Activation of Monoamine Oxidase A Is Regulated Differently by R1 and Sp1*

X. Ou, J. Shih, Kevin Chen, 2006, Journal of Biological Chemistry.

Activation of Human Monoamine Oxidase B Gene Expression by a Protein Kinase C MAPK Signal Transduction Pathway Involves c-Jun and Egr-1*

W. K. Wong, X. Ou, Kevin S. Chen, 2002, The Journal of Biological Chemistry.

Monoamine oxidase A (MAO A) inhibitors decrease glioma progression

Thomas C Chen, S. Groshen, J. Shih, 2016, Oncotarget.

A transient placental source of serotonin for the fetal forebrain

E. Deneris, R. Blakely, P. Levitt, 2011, Nature.

Retinoic Acid Activates Monoamine Oxidase B Promoter in Human Neuronal Cells*

X. Ou, Kevin S. Chen, J. Shih, 2009, The Journal of Biological Chemistry.

Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: Identification of two naturally occurring receptor variants and association analysis in schizophrenia

M. Rietschel, M. Nöthen, W. Maier, 1996, Human Genetics.

Schizophrenia, Monoamine Oxidase Activity, and Cigarette Smoking

G. Simpson, J. Shih, Kevin Chen, 1999, Neuropsychopharmacology.

No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan

H. Ko, Kevin S. Chen, J. Shih, 2002, Progress in Neuro-Psychopharmacology and Biological Psychiatry.

Serotonin2A receptor gene polymorphism in mood disorders

Kevin S. Chen, J. Shih, K. Ohara, 1997, Biological Psychiatry.

Characterization of the human 5-HT2A receptor gene promoter

J. Shih, Q. Zhu, Kevin Chen, 1995, The Journal of neuroscience : the official journal of the Society for Neuroscience.

Determination of transcription initiation sites and promoter activity of the human 5-HT2A receptor gene

J. Shih, Q. Zhu, Kevin Chen, 1995, Behavioural Brain Research.

Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate

Chun-Peng Liao, M. Gross, Chi-Hung Lin, 2018, Oncogene.

Dual Functions of Transcription Factors, Transforming Growth Factor-β-inducible Early Gene (TIEG)2 and Sp3, Are Mediated by CACCC Element and Sp1 Sites of Human Monoamine Oxidase (MAO) B Gene*

X. Ou, J. Shih, Kevin Chen, 2004, Journal of Biological Chemistry.

Down-Regulated GABAergic Expression in the Olfactory Bulb Layers of the Mouse Deficient in Monoamine Oxidase B and Administered With Amphetamine

J. Shih, H. Yin, T. Tien, 2010, Cellular and Molecular Neurobiology.

Differential effects of chronic amphetamine and baclofen administration on cAMP levels and phosphorylation of CREB in distinct brain regions of wild type and monoamine oxidase B‐deficient mice

J. Shih, S. Kalpana, H. Yin, 2006, Synapse.

Brain injury and inflammation genes common to a number of neurological diseases and the genes involved in the genesis of GABAnergic neurons are altered in monoamine oxidase B knockout mice

B. Tabakoff, Kevin S. Chen, J. Shih, 2021, Brain Research.

Analysis of Conserved Active Site Residues in Monoamine Oxidase A and B and Their Three-dimensional Molecular Modeling*

J. Wouters, J. Shih, F. Ooms, 2002, The Journal of Biological Chemistry.

Influence of C Terminus on Monoamine Oxidase A and B Catalytic Activity

J. Shih, Kevin Chen, Hsiu‐Fei Wu, 1996, Journal of Neurochemistry.

Glyceraldehyde-3-Phosphate Dehydrogenase–Monoamine Oxidase B-Mediated Cell Death-Induced by Ethanol is Prevented by Rasagiline and 1-R-Aminoindan

G. Rajkowska, M. Youdim, X. Ou, 2009, Neurotoxicity Research.

Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA.

P. Gaspar, J. Shih, C. Babinet, 1995, Science.

Structure and promoter organization of the human monoamine oxidase A and B genes.

J. Shih, J. Grimsby, Q. Zhu, 1993, Journal of psychiatry & neuroscience : JPN.

Modulation of [3H]quinpirole binding at striatal D2 dopamine receptors by a monoamine oxidaseA-like site: evidence from radioligand binding studies and D2 receptor- and MAO(A)-deficient mice.

D. Grandy, J. Shih, I. Seif, 2001, Life sciences.

Human monoamine oxidase A and B genes exhibit identical exon-intron organization.

J. Shih, N. Lan, K. Chen, 1991, Proceedings of the National Academy of Sciences of the United States of America.

Regulation of MAO-A and MAO-B gene expression.

J. Shih, Kevin Chen, K. Chen, 2004, Current medicinal chemistry.

The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake.

M. Bortolato, M. Ennas, A. Casti, 2014, Journal of Psychiatric Research.

Regulation of human monoamine oxidase B gene by Sp1 and Sp3.

J. Shih, Kevin Chen, Wai K. Wong, 2001, Molecular pharmacology.

Maladaptive defensive behaviours in monoamine oxidase A-deficient mice.

R. Frau, J. Shih, M. Bortolato, 2011, The international journal of neuropsychopharmacology.

Increased baroreceptor response in mice deficient in monoamine oxidase A and B.

D. Chialvo, O. Scremin, J. Shih, 2002, American journal of physiology. Heart and circulatory physiology.

MAO‐B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake

N. Hiroi, J. Shih, M. Lee, 2004, Genes, brain, and behavior.

Cloning of a novel monoamine oxidase cDNA from trout liver.

J. Shih, K. Chen, J. Grimsby, 1994, Molecular pharmacology.

Altered gene expression in early postnatal monoamine oxidase A knockout mice

B. Tabakoff, J. Shih, S. Flink, 2017, Brain Research.

Heart rate dynamics in monoamine oxidase-A- and -B-deficient mice.

D. Chialvo, O. Scremin, J. Shih, 2002, American journal of physiology. Heart and circulatory physiology.

Intact 5-HT2A receptor exons and the adjoining intron regions in schizophrenia.

K. Ohara, Hai-yin Zhang, T. Ishigaki, 1996, Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.

Regulation of monoamine oxidase A by the SRY gene on the Y chromosome

Yun-Fai Chris Lau, J. Shih, J. Wu, 2009, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Site-directed mutagenesis of serotonin 5-HT2 receptors

J. Shih, T. Gallaher, Kevin Chen, 1992, Journal of Chemical Neuroanatomy.