Eiji Kawanishi

发表

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for SARS-CoV-2 3CL Protease

A. Ojida, T. Ueda, S. Ohdo, 2022, bioRxiv.

First total synthesis of prunustatin A

Eiji Kawanishi, S. Yamakoshi, 2014 .

C-Glucosides with heteroaryl thiophene as novel sodium-dependent glucose cotransporter 2 inhibitors.

Y. Koga, S. Nomura, M. Tsuda-Tsukimoto, 2013, Bioorganic & medicinal chemistry.

N-Glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors.

Y. Koga, S. Nomura, M. Tsuda-Tsukimoto, 2013, Bioorganic & medicinal chemistry letters.

Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus.

Y. Koga, S. Nomura, M. Tsuda-Tsukimoto, 2010, Journal of medicinal chemistry.

Discovery of Chlorofluoroacetamide-Based Covalent Inhibitors for Severe Acute Respiratory Syndrome Coronavirus 2 3CL Protease.

A. Ojida, T. Ueda, S. Ohdo, 2022, Journal of medicinal chemistry.

Total synthesis of tetronolide, the aglycon of tetrocarcins

K. Takeda, E. Yoshii, Eiji Kawanishi, 1991 .

Chirality Transfer from Epoxide to Carbanion: Base‐Induced Alkylation of O‐Carbamoyl Cyanohydrins of β‐Silyl‐α,β‐epoxy Aldehyde

K. Takeda, H. Masu, K. Yamaguchi, 2008 .

Scalable Process Design for a PDE10A Inhibitor Consisting of Pyrazolopyrimidine and Quinoxaline as Key Units

Y. Moritani, Masayuki Utsugi, Eiji Toyofuku, 2019, Organic Process Research & Development.

Aryl-β-C-glucosidation using glucal boronate: application to the synthesis of tri-O-methylnorbergenin

T. Ishikawa, S. Nomura, Eiji Kawanishi, 2012 .

Synthetic Method for 2'-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction.

S. Obika, Eiji Kawanishi, S. Yamakoshi, 2018, Organic letters.

Computation-Assisted Disconnection Approach for the Synthesis of Neoantimycins, 15-Membered Macrocyclic Depsipeptides

Yuuki Arai, Kei Takeda, Michiko Sasaki, 2017 .

Tandem Base-Promoted Ring-Opening/Brook Rearrangement/Allylic Alkylation of O-Silyl Cyanohydrins of β-Silyl-α,β-epoxyaldehyde: Scope and Mechanism

K. Takeda, K. Yamaguchi, Eiji Kawanishi, 2003 .

Tandem Base-Promoted Ring Opening/Brook Rearrangement/Allylic Alkylation of O-Silyl Cyanohydrins of β-Silyl-α,β-epoxyaldehydes

K. Takeda, K. Yamaguchi, Eiji Kawanishi, 2002 .

Synthesis and properties of GuNA purine/pyrimidine nucleosides and oligonucleotides.

S. Obika, Katsuya Yamada, Takao Yamaguchi, 2020, Organic & biomolecular chemistry.

Discovery of a pyrazolo[1,5-a]pyrimidine derivative (MT-3014) as a highly selective PDE10A inhibitor via core structure transformation from the stilbene moiety.

J. Kotera, Takashi Sasaki, K. Takedomi, 2019, Bioorganic & medicinal chemistry.

Phosphodiesterase 10A PET Radioligand Development Program: From Pig to Human

S. Kapur, R. Carson, D. Weinzimmer, 2014, The Journal of Nuclear Medicine.

Selective covalent targeting of SARS-CoV-2 main protease by enantiopure chlorofluoroacetamide

K. Mizuguchi, A. Ojida, Suyong Re, 2021, Chemical science.

N-Glucosides as human sodium-dependent glucose cotransporter 2 (hSGLT2) inhibitors.

Y. Koga, S. Nomura, M. Tsuda-Tsukimoto, 2013, Bioorganic & medicinal chemistry letters.

Discovery of 2-[(E)-2-(7-Fluoro-3-methylquinoxalin-2-yl)vinyl]-6-pyrrolidin-1-yl-N-(tetrahydro-2H-pyran-4-yl)pyrimidin-4-amine Hydrochloride as a Highly Selective PDE10A Inhibitor.

J. Kotera, K. Omori, Takashi Sasaki, 2018, Chemical and pharmaceutical bulletin.