E. Fernandez

发表

Structural understanding of stabilization patterns in engineered bispecific Ig‐like antibody molecules

Guohui Li, A. Lugovskoy, Xiufeng Wu, 2009, Proteins.

A new thermodynamic model describes the effects of ligand density and type, salt concentration and protein species in hydrophobic interaction chromatography.

J. O’Connell, E. Fernandez, R. W. Deitcher, 2010, Journal of chromatography. A.

Kinetic study of β‐amyloid residue accessibility using reductive alkylation and mass spectrometry

D. Fabris, T. Good, W. Qi, 2009, Biotechnology and bioengineering.

Systematic measurements of peptide adsorption in hydrophobic chromatography

A. Freed, Kosta Makrodimitris, E. Fernandez, 2006 .

Erratum: A nuclear magnetic resonance technique for determining hybridoma cell concentration in hollow fiber bioreactors

H. Blanch, A. Mancuso, D. Clark, 1990, Nature Biotechnology.

A Column Design for Reducing Viscous Fingering in Size Exclusion Chromatography

John G. Tsavalas, T. Norton, E. Fernandez, 1996 .

Analysis of column tortuosity for MnCl2 and bacterial diffusion using magnetic resonance imaging.

James A. Smith, M. Olson, E. Fernandez, 2005, Environmental science & technology.

Molecular level insights into thermally induced α-chymotrypsinogen A amyloid aggregation mechanism and semiflexible protofibril morphology.

William F. Weiss, M. Ivanova, C. Roberts, 2010, Biochemistry.

Monitoring Human Copper/Zinc Superoxide Dismutase Misfolding/Aggregation in Mammalian Cells

Inchan Kwon, Jacob A. Irwin, S. Zheng, 2012 .

Structural Differences between A b (1-40) Intermediate Oligomers and Fibrils Elucidated by Proteolytic Fragmentation and Hydrogen/Deuterium Exchange

T. Good, W. Qi, Aming Zhang, 2009 .

Benzyl alcohol-induced destabilization of interferon-gamma: a study by hydrogen-deuterium isotope exchange.

M. Cromwell, S. Tobler, E. Fernandez, 2004, Journal of pharmaceutical sciences.

Quantification of bacterial chemotaxis in porous media using magnetic resonance imaging.

James A. Smith, M. Olson, E. Fernandez, 2004, Environmental science & technology.

The appearance of rapidly flowing blood on magnetic resonance images.

W G Bradley, W. Bradley, V. Waluch, 1984, AJR. American journal of roentgenology.

Evaluation of polymer matrices for an adsorptive approach to plasma detoxification.

G. Carta, Courtney A. Ober, J. Costanzo, 2010, Biomaterials.

Distinct Aggregation Mechanisms of Monoclonal Antibody Under Thermal and Freeze-Thaw Stresses Revealed by Hydrogen Exchange

M. Shirts, Sandeep Kumar, Aming Zhang, 2011, Pharmaceutical Research.

Structures of multidomain proteins adsorbed on hydrophobic interaction chromatography surfaces.

J. O’Connell, Weitong Sun, E. J. Fernandez, 2014, Journal of chromatography. A.

Protein instability during HIC: Hydrogen exchange labeling analysis and a framework for describing mobile and stationary phase effects

J. O’Connell, T. Przybycien, Yunzhi Xiao, 2007, Biotechnology and bioengineering.

Loading, stationary phase, and salt effects during hydrophobic interaction chromatography: alpha-lactalbumin is stabilized at high loadings.

J. O’Connell, E. Fernandez, Jace L. Fogle, 2006, Journal of chromatography. A.

How does a protein unfold on a reversed-phase liquid chromatography surface? ☆

E. Fernandez, J. McNay, J. L. McNay, 1999 .

Hydrophobic interaction chromatography selectivity changes among three stable proteins: conformation does not play a major role

E. J. Fernandez, Tara Tibbs Jones, E. Fernandez, 2004, Biotechnology and bioengineering.

Membrane interactions of a self-assembling model peptide that mimics the self-association, structure and toxicity of Abeta(1-40).

L. Tamm, W. Qi, L. C. Salay, 2009, Biochimica et biophysica acta.

Elucidating Structure, Stability, and Conformational Distributions during Protein Aggregation with Hydrogen Exchange and Mass Spectrometry

S. Tobler, E. Fernandez, 2006 .

Structural features of interferon‐γ aggregation revealed by hydrogen exchange

S. Tobler, E. Fernandez, 2002 .

Modulating non-native aggregation and electrostatic protein-protein interactions with computationally designed single-point mutations.

M. Blanco, A. Robinson, C. Roberts, 2016, Protein engineering, design & selection : PEDS.

Cis‐suppression to arrest protein aggregation in mammalian cells

Shaojie Zhang, Inchan Kwon, J. Costanzo, 2014, Biotechnology and bioengineering.

Conformational stability as a design target to control protein aggregation.

Christopher J Roberts, A. Robinson, C. Roberts, 2014, Protein engineering, design & selection : PEDS.

Computational design and biophysical characterization of aggregation-resistant point mutations for γD crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity.

William F. Weiss, Andrea Naranjo, Erinc Sahin, 2011, Biochemistry.

A safe, blood-brain barrier permeable triphenylmethane dye inhibits amyloid-β neurotoxicity by generating nontoxic aggregates.

Inchan Kwon, Hyung-Min Choi, W. Qi, 2011, ACS chemical neuroscience.

A New Approach to Explore the Impact of Freeze-Thaw Cycling on Protein Structure: Hydrogen/Deuterium Exchange Mass Spectrometry (HX-MS)

Satish K. Singh, S. Singh, W. Qi, 2011, Pharmaceutical Research.

Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Aβ fibril formation pathway

T. Good, Sungmun Lee, Sungmun Lee, 2007, Protein science : a publication of the Protein Society.

In situ analysis of protein chromatography and column efficiency using magnetic resonance imaging.

L. Hagel, E. Fernandez, N. S. Mitchell, 1997, Journal of chromatography. A.

N.m.r. spectroscopy: A non-invasive tool for studying intracellular processes

Douglas S. Clark, D. Clark, Erik J. Fernandez, 1987 .

Aggregation of anti-streptavidin immunoglobulin gamma-1 involves Fab unfolding and competing growth pathways mediated by pH and salt concentration.

Christopher J Roberts, Vladimir I Razinkov, C. Roberts, 2013, Biophysical chemistry.

Thermodynamics of amyloid dissociation provide insights into aggregate stability regimes.

C. Roberts, R. Brummitt, J. Andrews, 2012, Biophysical chemistry.

Protein instability during HIC: Describing the effects of mobile phase conditions on instability and chromatographic retention

J. O’Connell, Yunzhi Xiao, Kosta Makrodimitris, 2006, Biotechnology and bioengineering.

The effects of permeability heterogeneity on miscible viscous fingering: A three‐dimensional magnetic resonance imaging analysis

C. Grotegut, E. Fernandez, Veronica L. Fernandez, 1995 .

Chemical imaging of multicomponent viscous fingering in chromatography

T. Norton, E. Fernandez, Matthew L. Dickson, 1997 .

Viscous fingering in chromatography visualized via magnetic resonance imaging

Erik J. Fernandez, Lyn D. Plante, Paul M. Romano, 1994 .

Viscous Fingering in Size Exclusion Chromatography: Insights from Numerical Simulation

T. Norton, E. Fernandez, 1996 .

Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: Application to Aβ(1‐40) fibrillogenesis

Liming Zhao, T. Good, W. Qi, 2008, Biotechnology and bioengineering.

Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability.

T. Good, W. Qi, Aming Zhang, 2009, Biochemistry.

Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange.

T. Good, W. Qi, Wei Qi, 2009, Biophysical journal.

Protein stability and structure in HIC: hydrogen exchange experiments and COREX calculations.

J. O’Connell, A. Gospodarek, E. Fernandez, 2011, Langmuir : the ACS journal of surfaces and colloids.

Protein instability during HIC: Evidence of unfolding reversibility, and apparent adsorption strength of disulfide bond‐reduced α‐lactalbumin variants

J. O’Connell, Y. Xiao, E. Fernandez, 2009, Biotechnology and bioengineering.

Protein unfolding during reversed-phase chromatography: II. Role of salt type and ionic strength.

J. O’Connell, E. Fernandez, J. McNay, 2001, Biotechnology and bioengineering.

Protein unfolding during reversed-phase chromatography: I. Effect of surface properties and duration of adsorption.

E. Fernandez, J. McNay, J. L. McNay, 2001, Biotechnology and bioengineering.

QCM-D sensitivity to protein adsorption reversibility.

Jacob L. Jordan, E. Fernandez, 2008, Biotechnology and bioengineering.

Tracking lysozyme unfolding during salt-induced precipitation with hydrogen exchange and mass spectrometry.

N. Sherman, S. Tobler, E. Fernandez, 2000, Biotechnology and bioengineering.

Distinct Aggregation Mechanisms of Monoclonal Antibody Under Thermal and Freeze-Thaw Stresses Revealed by Hydrogen Exchange

Michael R. Shirts, M. Shirts, Sandeep Kumar, 2011, Pharmaceutical Research.

Effect of extracellular glutamine concentration on primary and secondary metabolism of a murine hybridoma: an in vivo 13C nuclear magnetic resonance study.

H. Blanch, A. Mancuso, D. Clark, 1998, Biotechnology and bioengineering.

31P NMR investigation of energy metabolism in perifused MMQ cells

C. Grisham, M. Goger, I. Login, 1994, Magnetic resonance in medicine.

Unfolding of a model protein on ion exchange and mixed mode chromatography surfaces.

J. O’Connell, Erik J Fernandez, A. Gospodarek, 2014, Journal of chromatography. A.

Reduction of the C191-C220 disulfide of α-chymotrypsinogen A reduces nucleation barriers for aggregation.

William F. Weiss, M. Ivanova, Erinc Sahin, 2014, Biophysical chemistry.

Changes in solvent exposure reveal the kinetics and equilibria of adsorbed protein unfolding in hydrophobic interaction chromatography.

J. O’Connell, E. Fernandez, R. W. Deitcher, 2010, Journal of chromatography. A.

ALLD: An object-oriented mesoscopic simulation program for polar biomolecules in hydrophobic chromatography or biomembranes

T. Woolf, J. O’Connell, E. J. Fernandez, 2005 .

A Nuclear Magnetic Resonance Technique for Determining Hybridoma Cell Concentration in Hollow Fiber Bioreactors

H. Blanch, A. Mancuso, D. Clark, 1990, Bio/Technology.

Surface association of motile bacteria and apparent tortuosity values in packed column experiments

James A. Smith, Karthik Narayanaswamy, E. Fernandez, 2009 .

Aprotinin conformational distributions during reversed-phase liquid chromatography. Analysis by hydrogen-exchange mass spectrometry.

J. O’Connell, E. Fernandez, B. Holmes, 2003, Journal of chromatography. A.

Probing residue-level unfolding during lysozyme precipitation.

E. Fernandez, S. T. Chang, 1998, Biotechnology and bioengineering.

Hydrogen Exchange-Mass Spectrometry Analysis of β-Amyloid Peptide Structure†

T. Good, S. Tobler, E. Fernandez, 2003 .

Hydrogen exchange-mass spectrometry analysis of beta-amyloid peptide structure.

T. Good, S. Tobler, E. Fernandez, 2003, Biochemistry.

The solution structure and dynamics of the DH‐PH module of PDZRhoGEF in isolation and in complex with nucleotide‐free RhoA

D. Svergun, T. Cierpicki, J. Bushweller, 2009, Protein science : a publication of the Protein Society.

Generalizing a two-conformation model for describing salt and temperature effects on protein retention and stability in hydrophobic interaction chromatography.

A. Rathore, J. O’Connell, E. J. Fernandez, 2007, Journal of chromatography. A.

Structural understanding of stabilization patterns in engineered bispecific Ig‐like antibody molecules

Guohui Li, A. Lugovskoy, Xiufeng Wu, 2009, Proteins.

Cis‐suppression to arrest protein aggregation in mammalian cells

Shaojie Zhang, Inchan Kwon, J. Costanzo, 2014, Biotechnology and bioengineering.

Unfolding and Conformational Distributions during Protein Precipitation

S. Tobler, E. Fernandez, Stephen T. Chang, 2001, Biotechnology progress.

Mathematical Modeling of Chemotactic Bacterial Transport through a Two-Dimensional Heterogeneous Porous Medium

James A. Smith, M. Olson, E. Fernandez, 2006 .

NMR Spectroscopy Studies of Hybridoma Metabolism in a Simple Membrane Reactor

Douglas S. Clark, Anthony Mancuso, A. Mancuso, 1988 .

Alpha-lactalbumin tertiary structure changes on hydrophobic interaction chromatography surfaces.

Tara Tibbs Jones, E. Fernandez, 2003, Journal of colloid and interface science.

The solution structure and dynamics of the DH‐PH module of PDZRhoGEF in isolation and in complex with nucleotide‐free RhoA

D. Svergun, T. Cierpicki, J. Bushweller, 2009, Protein science : a publication of the Protein Society.

Nuclear Magnetic Resonance Methods for Observing the Intracellular Environment of Mammalian Cells a

H. Blanch, A. Mancuso, D. Clark, 1990, Annals of the New York Academy of Sciences.

THz characterization of lysozyme at different conformations

Dwight L. Woolard, Nathan Swami, Tatiana Globus, 2005, SPIE Defense + Commercial Sensing.

Mesoscopic simulation of adsorption of peptides in a hydrophobic chromatography system.

T. Woolf, J. O’Connell, Kosta Makrodimitris, 2005, Analytical chemistry.

Kinetic study of β‐amyloid residue accessibility using reductive alkylation and mass spectrometry

D. Fabris, T. Good, W. Qi, 2009 .

Analysis of bacterial random motility in a porous medium using magnetic resonance imaging and immunomagnetic labeling.

James A. Smith, J. Sung, J. Maneval, 2003, Environmental science & technology.

Toward a Robust Model of Packing and Scale‐Up for Chromatographic Beds. 1. Mechanical Compression

J. Maneval, E. Fernandez, R. N. Keener, 2004, Biotechnology progress.

Toward a Robust Model of Packing and Scale‐Up for Chromatographic Beds. 2. Flow Packing

J. Maneval, E. Fernandez, R. N. Keener, 2004, Biotechnology progress.