K. Frankowski

发表

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

T. Willson, S. K. R. Guduru, S. Frye, 2022, Alzheimer's & dementia.

Evaluating p97 Inhibitor Analogues for Potency against p97–p37 and p97–Npl4–Ufd1 Complexes

Henry J. Lin, T. Chou, F. Schoenen, 2016, ChemMedChem.

Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands

V. Setola, B. Roth, Benjamin Neuenswander, 2011, Proceedings of the National Academy of Sciences.

Small-Molecule Disruptors of Mutant Huntingtin-Calmodulin Protein-Protein Interaction Attenuate Deleterious Effects of Mutant Huntingtin.

J. Aubé, N. Muma, Anuradha Roy, 2022, ACS chemical neuroscience.

Table 1, Listing of all Assays and AIDs for this project

Susanne Heynen-Genel, Shenghua Shi, Thomas D.Y. Chung, 2010 .

Investigation of the role of βarrestin2 in kappa opioid receptor modulation in a mouse model of pruritus

L. Bohn, T. Prisinzano, J. Aubé, 2015, Neuropharmacology.

Autophagy activation by novel inducers prevents BECN2-mediated drug tolerance to cannabinoids

J. Marugan, Weiran Zhang, Congcong He, 2016, Autophagy.

Structure–activity relationship investigation of triazole-based kappa opioid receptor agonists

L. Bohn, K. Lovell, J. Aubé, 2021 .

Structure-activity relationship studies of functionally selective kappa opioid receptor agonists that modulate ERK 1/2 phosphorylation while preserving G protein over βarrestin2 signaling bias.

L. Bohn, K. Lovell, Stephen R Slauson, 2015, ACS chemical neuroscience.

Advances in Sulfonamide Kappa Opioid Receptor Antagonists: Structural Refinement and Evaluation of CNS Clearance.

L. Bohn, K. Lovell, M. Cameron, 2022, ACS chemical neuroscience.

Potency enhancement of the κ-opioid receptor antagonist probe ML140 through sulfonamide constraint utilizing a tetrahydroisoquinoline motif.

L. Bohn, Lei Zhou, K. Lovell, 2015, Bioorganic & medicinal chemistry.

Discovery and Optimization of Pyrrolopyrimidine Derivatives as Selective Disruptors of the Perinucleolar Compartment, a Marker of Tumor Progression toward Metastasis.

M. Ferrer, Noel Southall, A. Jadhav, 2022, Journal of medicinal chemistry.

Characterization of kappa opioid receptor mediated, dynorphin-stimulated [35S]GTPγS binding in mouse striatum for the evaluation of selective KOR ligands in an endogenous setting

L. Bohn, Lei Zhou, K. Lovell, 2015, Neuropharmacology.

Development of Pyrimidone D1 Dopamine Receptor Positive Allosteric Modulators.

D. Sibley, J. Aubé, Prashi Jain, 2020, Bioorganic & Medicinal Chemistry Letters.

Chemotype-selective Modes of Action of κ-Opioid Receptor Agonists*

R. Stevens, B. Roth, V. Katritch, 2013, The Journal of Biological Chemistry.

Syntheses of the Stemona alkaloids (+/-)-stenine, (+/-)-neostenine, and (+/-)-13-epineostenine using a stereodivergent Diels-Alder/azido-Schmidt reaction.

Jennifer E. Golden, J. Aubé, Yibin Zeng, 2008, Journal of the American Chemical Society.

Fluorescent primuline derivatives inhibit hepatitis C virus NS3-catalyzed RNA unwinding, peptide hydrolysis and viral replicase formation.

Alicia M. Hanson, Noreena L. Sweeney, S. Mukherjee, 2012, Antiviral research.

Grubbs's cross metathesis of eugenol with cis-2-butene-1,4-diol to make a natural product. An organometallic experiment for the undergraduate lab

D. Taber, K. Frankowski, 2006 .

Simultaneously Targeting the NS3 Protease and Helicase Activities for More Effective Hepatitis C Virus Therapy.

Akbar Ali, Kelin Li, Alicia M. Hanson, 2015, ACS chemical biology.

Discovery, Optimization and Characterization of ML417: A Novel and Highly Selective D3 Dopamine Receptor Agonist.

Ara M. Abramyan, M. Ferrer, D. Sibley, 2020, Journal of medicinal chemistry.

Divergent Electrochemical Carboamidation of Cyclic Amines.

Fei-jun Wang, K. Frankowski, 2022, Journal of Organic Chemistry.

Chapter 12 The total synthesis of amphibian alkaloids using the intramolecular schmidt reaction

Kevin J Frankowski, J. Aubé, A. Wrobleski, 2008 .

Grubbs' catalyst in paraffin: an air-stable preparation for alkene metathesis.

Kevin J Frankowski, D. Taber, Douglass F Taber, 2003, The Journal of organic chemistry.

Synthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence.

L. Bohn, K. Lovell, J. Aubé, 2016, The Journal of organic chemistry.

Efficient Synthesis of γ‐Lactams by a Tandem Reductive Amination/Lactamization Sequence.

Benjamin Neuenswander, J. Aubé, O. Reiser, 2008 .

Development of an Aryloxazole Class of Hepatitis C Virus Inhibitors Targeting the Entry Stage of the Viral Replication Cycle.

M. Ferrer, Noel Southall, Shanshan He, 2017, Journal of medicinal chemistry.

Practical Electrochemical Anodic Oxidation of Polycyclic Lactams for Late Stage Functionalization.

Jeffrey Aubé, Kevin J Frankowski, J. Aubé, 2015, Angewandte Chemie.

Explorations of stemona alkaloid-inspired analogues: skeletal modification and functional group diversification.

Benjamin Neuenswander, Jeffrey Aubé, Benjamin Neuenswander, 2008, Journal of combinatorial chemistry.

Metarrestin, a perinucleolar compartment inhibitor, effectively suppresses metastasis

K. Nagashima, M. Ferrer, A. Shilatifard, 2018, Science Translational Medicine.

Benzothiazole and Pyrrolone Flavivirus Inhibitors Targeting the Viral Helicase.

Alicia M. Hanson, Noreena L. Sweeney, B. Geiss, 2015, ACS infectious diseases.

Hepatitis C Virus NS3 Helicase Inhibitor Discovery

Alicia M. Hanson, Noreena L. Sweeney, Craig A. Belon, 2013 .

Helicase-catalyzed ATP Hydrolysis Stimulate Hepatitis C Virus NS 3 Primuline Derivatives That Mimic RNA to Enzymology :

Noreena L. Sweeney, S. Mukherjee, F. Schoenen, 2013 .

Identification and analysis of hepatitis C virus NS3 helicase inhibitors using nucleic acid binding assays

Alicia M. Hanson, Noreena L. Sweeney, S. Mukherjee, 2012, Nucleic acids research.

Optimization of potent hepatitis C virus NS3 helicase inhibitors isolated from the yellow dyes thioflavine S and primuline.

Jeffrey Aubé, Kelin Li, Alicia M. Hanson, 2012, Journal of medicinal chemistry.

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy.

M. Caron, T. Chung, M. Hedrick, 2012, ACS chemical neuroscience.

Efficient synthesis of gamma-lactams by a tandem reductive amination/lactamization sequence.

Benjamin Neuenswander, J. Aubé, O. Reiser, 2008, Journal of combinatorial chemistry.

Pharmacokinetic evaluation of the PNC disassembler metarrestin in wild-type and Pdx1-Cre;LSL-KrasG12D/+;Tp53R172H/+ (KPC) mice, a genetically engineered model of pancreatic cancer

M. Ferrer, Noel Southall, A. Wang, 2018, Cancer Chemotherapy and Pharmacology.

Primuline Derivatives That Mimic RNA to Stimulate Hepatitis C Virus NS3 Helicase-catalyzed ATP Hydrolysis*

Noreena L. Sweeney, S. Mukherjee, F. Schoenen, 2013, The Journal of Biological Chemistry.

Evaluating p97 Inhibitor Analogues for Their Domain Selectivity and Potency against the p97–p47 Complex

Henry J. Lin, T. Chou, F. Schoenen, 2015, ChemMedChem.

Structure–Activity Relationship Study Reveals ML240 and ML241 as Potent and Selective Inhibitors of p97 ATPase

R. Deshaies, T. Chou, F. Schoenen, 2013, ChemMedChem.

Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors*

A. M. Phillips, L. Bohn, Lei Zhou, 2013, The Journal of Biological Chemistry.

Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

Noel Southall, Zongyi Hu, Xin Hu, 2020, Nature Microbiology.

Fluoxazolevir inhibits hepatitis C virus infection in humanized chimeric mice by blocking viral membrane fusion

Noel Southall, Zongyi Hu, Xin Hu, 2020, Nature microbiology.

Use of AD Informer Set compounds to explore validity of novel targets in Alzheimer's disease pathology

T. Willson, S. Frye, Jessica E. Young, 2022, Alzheimer's & dementia.

AD Informer Set: Chemical tools to facilitate Alzheimer's disease drug discovery

T. Willson, S. Frye, Jessica E. Young, 2021, bioRxiv.

Decahydrobenzoquinolin-5-one sigma receptor ligands: Divergent development of both sigma 1 and sigma 2 receptor selective examples.

J. Aubé, Michael C. McLeod, K. Frankowski, 2016, Bioorganic & medicinal chemistry letters.

Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D2 Dopamine Receptor

D. Sibley, Y. Namkung, S. Laporte, 2018, Front. Synaptic Neurosci..

Synthesis of (+)-sulcatine G.

D. Taber, K. Frankowski, 2005, The Journal of organic chemistry.

Selective, reversible inhibitors of the AAA ATPase p97

Patrick Porubsky, Jeffrey Aubé, Kevin J. Frankowski, 2013 .

N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: Selective and Nonbasic κ-Opioid Receptor Ligands

V. Setola, B. Roth, P. Ghosh, 2010 .

Opioid Receptor Agonists κ Chemotype-selective Modes of Action of Signal Transduction :

R. Stevens, B. Roth, V. Katritch, 2013 .

Synthesis of N-alkyl-octahydroisoquinolin-1-one-8-carboxamide libraries using a tandem Diels-Alder/acylation sequence.

Benjamin Neuenswander, D. Fowler, J. Aubé, 2007, Journal of combinatorial chemistry.

Identification of Positive Allosteric Modulators of the D1 Dopamine Receptor That Act at Diverse Binding Sites

M. Ferrer, D. Sibley, Noel Southall, 2018, Molecular Pharmacology.

High-Throughput Screening, Discovery, and Optimization To Develop a Benzofuran Class of Hepatitis C Virus Inhibitors.

M. Ferrer, Noel Southall, Shanshan He, 2015, ACS combinatorial science.

Synthesis and receptor profiling of Stemona alkaloid analogues reveal a potent class of sigma ligands

V. Setola, B. Roth, Benjamin Neuenswander, 2011, Proceedings of the National Academy of Sciences.

Development of Functionally Selective, Small Molecule Agonists at Kappa Opioid Receptors*

L. Bohn, Lei Zhou, K. Lovell, 2013, The Journal of Biological Chemistry.

Discovery of FERM domain protein–protein interaction inhibitors for MSN and CD44 as a potential therapeutic approach for Alzheimer’s disease

T. Willson, A. Wingo, N. Seyfried, 2023, The Journal of biological chemistry.

Evaluating p97 Inhibitor Analogues for Potency against p97–p37 and p97–Npl4–Ufd1 Complexes

Henry J. Lin, T. Chou, F. Schoenen, 2016, ChemMedChem.

Generation of the AD Informer Set: Chemical tools to facilitate Alzheimer’s disease drug discovery

T. Willson, S. Frye, Jessica E. Young, 2021, Alzheimer's & Dementia.

N-Alkyl-octahydroisoquinolin-1-one-8-carboxamides: a Novel Class of Selective, Nonbasic, Nitrogen-Containing κ-Opioid Receptor Ligands.

V. Setola, B. Roth, P. Ghosh, 2010, ACS medicinal chemistry letters.