P. Brookes

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The distribution of benzo(a)pyrene DNA adducts in mammalian chromatin.

P. Jack, P. Brookes, 1981, Nucleic acids research.

The reaction of 7,8-dihydro-7,8-dihydroxybenzo (a) pyrene-9,10-oxide with DNA in relation to the benzo (a) pyrene-DNA products isolated from cells.

R. Harvey, E. Tarmy, M. Osborne, 1976, Chemico-biological interactions.

The reaction of mono- and di-functional alkylating agents with nucleic acids.

P. D. Lawley, P. Brookes, 1961, The Biochemical journal.

766. The alkylation of guanosine and guanylic acid

P. D. Lawley, P. Brookes, 1961 .

Cell‐mediated mutagenesis in cultured chinese hamster cells by polycyclic hydrocarbons: Mutagenicity and DNA reaction related to carcinogenicity in a series of compounds

R. Newbold, J. Amos, C. Wigley, 1979, International journal of cancer.

The reaction of mustard gas with nucleic acids in vitro and in vivo.

P. D. Lawley, P. Brookes, 1960, The Biochemical journal.

The Benzo(0)pyrene Deoxyribonucleoside Products Isolated from DNA after Metabolism of Benzo(o)pyrene by Rat Liver Microsomes in the Presence of DNA1

P. Brookes, Michael, H. King, 2006 .

The role of 9‐hydroxybenzo(a)pyrene in the microsome mediated binding of benzo(a)pyrene to dna

M. Thompson, P. Brookes, H. King, 1976, International journal of cancer.

The relation of metabolism to macromolecular binding of the carcinogen benzo[a]pyrene, by mouse embryo cells in culture

M. Duncan, P. Brookes, 1970, International journal of cancer.

Characterization of the mouse met proto-oncogene.

E. A. Deakin, C. Cooper, D. Edwards, 1988, Oncogene.

Studies on the formation of hydrocarbon-deoxyribonucleoside products by the binding of derivatives of 7-methylbenz(a)anthracene to DNA in aqueous solution and in mouse embryo cells in culture.

A. Dipple, W. Baird, P. Grover, 1973, Cancer research.

Mutation in mammalian cells by stereoisomers of anti-benzo[a] pyrene-diolepoxide in relation to the extent and nature of the DNA reaction products.

M. Osborne, P. Brookes, 1982, Carcinogenesis.

Minor products from the reaction of (+) and (-) benzo[a]-pyrene-anti-diolepoxide with DNA.

R. Harvey, M. Osborne, P. Brookes, 1981, Carcinogenesis.

Developmental and Metabolic Control Mechanisms and Neoplasia.

P. Brookes, 1968 .

A quantitative comparison of the mutagenicity of carcinogenic polycyclic hydrocarbon derivatives in cultured mammalian cells

R. Harvey, R. Newbold, P. Brookes, 1979, International journal of cancer.

Carcinogenic Hydrocarbons and Human Cells in Culture

M. Duncan, P. Brookes, 1971, Nature.

Ionization of DNA bases or base analogues as a possible explanation of mutagenesis, with special reference to 5-bromodeoxyuridine.

P. D. Lawley, P. Brookes, 1962, Journal of molecular biology.

Role of intercalation in polycyclic aromatic hydrocarbon carcinogenesis.

S. Venitt, J. DiGiovanni, R. Harvey, 1985, Carcinogenesis; a comprehensive survey.

Reflections on possible mechanisms of action of anti-inflammatory drugs.

W. Dick, P. Lee, P. Rooney, 1973, Current medical research and opinion.

Biochemical and immunological characterisation of mutants induced in V79 Chinese hamster cells by a benzo[a]pyrene diolepoxide.

C. Mundy, R. Newbold, P. Brookes, 1982, Carcinogenesis.

Nature of Alkylation Lesions and Their Repair: Significance for Ideas on Mutagenesis

S. Venitt, P. D. Lawley, P. Brookes, 2008 .

Electrofluorescence study of polycyclic hydrocarbon diol-epoxide binding to DNA

B. R. Jennings, M. Osborne, P. Brookes, 1986, Proceedings of the Royal Society of London. Series B. Biological Sciences.

The identification of 3-methylcholanthrene-9,10-dihydrodiol as an intermediate in the binding of 3-methylcholanthrene to DNA in cells in culture.

M. Osborne, P. Brookes, H. King, 1978, Chemico-biological interactions.

The metabolism and dna binding of 3‐methyl‐cholanthrene

M. Osborne, P. Brookes, H. King, 1977, International journal of cancer.

Exceptional mutagenicity of a benzo[a]pyrene diol epoxide in cultured mammalian cells

R. Newbold, P. Brookes, 1976, Nature.

Effects on DNA: Chemical Methods

P. D. Lawley, P. Brookes, 1971 .

Isolation of the hydrocarbon-deoxyribonucleoside products from the DNA of mouse embryo cells treated in culture with 7-methylbenz(a)anthracene-3H.

W. Baird, P. Brookes, 1973, Cancer research.

The early history of the biological alkylating agents, 1918-1968.

P. Brookes, 1990, Mutation research.

(+/-)-7alpha,8beta-dihydroxy-9beta,10beta-epoxy-7,8,9,10-tetrahydrobenzo(a)-pyrene is an intermediate in the metabolism and binding to DNA of benzo(a)pyrene.

R. Harvey, M. Osborne, F. A. Beland, 1976, Proceedings of the National Academy of Sciences of the United States of America.

Mutagenicity of polycyclic aromatic hydrocarbons.

P. Brookes, 1977, Mutation research.

The reaction of (±)‐7α, 8β‐dihydroxy‐9β, 10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(a)pyrene with dna

R. Harvey, M. Osborne, P. Brookes, 1976 .

FURTHER STUDIES ON THE ALKYLATION OF NUCLEIC ACIDS AND THEIR CONSTITUENT NUCLEOTIDES.

P. D. Lawley, P. Brookes, 1963, The Biochemical journal.

The interaction of 7,12-dimethylbenz(a)anthracene with cells sensitive and resistant to toxicity induced by this carcinogen.

V. Defendi, L. Diamond, P. Brookes, 1967, Cancer research.

Effects of alkylating agents on the induced synthesis of beta-galactosidase by Escherichia coli Bs-1.

S. Venitt, P. D. Lawley, P. Brookes, 1968, Biochimica et biophysica acta.

Molecular Mechanism of the Cytotoxic Action of Difunctional Alkylating Agents and of Resistance to this Action

P. D. Lawley, P. Brookes, P. D. LAWLEY, 1965, Nature.

Cytotoxicity of alkylating agents towards sensitive and resistant strains of Escherichia coli in relation to extent and mode of alkylation of cellular macromolecules and repair of alkylation lesions in deoxyribonucleic acids.

P. D. Lawley, P. Brookes, 1968, The Biochemical journal.

Quantitative aspects of the reaction of some carcinogens with nucleic acids and the possible significance of such reactions in the process of carcinogenesis.

P. Brookes, 1966, Cancer research.

The 7-methylbenz(a)anthracene deoxyribonucleoside products isolated from DNA after metabolism of the carcinogen by rat liver microsomes in the presence of DNA.

M. Osborne, M. Thompson, P. Brookes, 1976, Chemico-biological interactions.

Methylation of adenine in deoxyadenylic acid or deoxyribonucleic acid at N-7.

P. D. Lawley, P. Brookes, 1964, The Biochemical journal.

112. The methylation of adenosine and adenylic acid

P. D. Lawley, P. Brookes, 1960 .

Theory of tumour initiation by chemical carcinogens: dependence of activity on structure of ultimate carcinogen.

A. Dipple, P. D. Lawley, P. Brookes, 1968, European journal of cancer.

Interstrand cross-linking of DNA by difunctional alkylating agents.

P. D. Lawley, P. Brookes, 1967, Journal of molecular biology.

254. The methylation of cystosine and cytidine

P. D. Lawley, P. Brookes, 1962 .

Retention of tritium during the binding of tritiated benzo(a)pyrene to DNA

M. Osborne, M. Thompson, P. Brookes, 1975, International Journal of Cancer.

Evidence for the Binding of Polynuclear Aromatic Hydrocarbons to the Nucleic Acids of Mouse Skin : Relation between Carcinogenic Power of Hydrocarbons and their Binding to Deoxyribonucleic Acid

P. D. Lawley, P. Brookes, 1964, Nature.

REACTION OF SOME MUTAGENIC AND CARCINOGENIC COMPOUNDS WITH NUCLEIC ACIDS.

P. D. Lawley, P. Brookes, 1964, Journal of cellular and comparative physiology.

EVIDENCE FOR THE ACTION OF ALKYLATING AGENTS ON DEOXYRIBONUCLEIC ACID.

P. D. Lawley, P. Brookes, 1963, Experimental cell research.

The induction of azaguanine-resistant mutants in cultured Chinese hamster cells by reactive derivatives of carcinogenic hydrocarbons.

M. Duncan, P. Brookes, 1973, Mutation research.

The nature of benzo[a]pyrene binding to dna in an epithelial cell culture system.

M. Thompson, C. Wigley, P. Brookes, 1976 .

Comparison of the metabolism of benzo[alpha]pyrene and binding to DNA caused by rat liver nuclei and microsomes.

M. Osborne, K. Alexandrov, M. Thompson, 1976, Chemico-biological interactions.

Comparison of the cellular DNA-bound products of benzo(alpha)pyrene with the products formed by the reaction of benzo(alpha)pyrene-4,5-oxide with DNA.

W. Baird, R. Harvey, P. Brookes, 1975, Cancer research.

Rat liver microsome‐mediated binding of benzo(A)pyrene metabolites to DNA

M. Osborne, M. Thompson, P. Brookes, 1976, International journal of cancer.

The nature of the deoxyribonucleosides involved in the binding of carcinogenic hydrocarbons to the DNA of mouse embryo cells

P. Brookes, Pamela Jones, Jacqueline Amos, 1975, International journal of cancer.

The benzo(alpha)pyrene deoxyribonucleoside products isolated from DNA after metabolism of benzo(alpha)pyrene by rat liver microsomes in the presence of DNA.

M. Thompson, P. Brookes, H. King, 1975, Cancer research.

Metabolism and binding to cellular macromolecules of a series of hydrocarbons by mouse embryo cells in culture

A. Dipple, M. Duncan, P. Brookes, 1969, International journal of cancer.

Biological Effects of Specific Hydrocarbon-DNA Reactions

R. Newbold, P. Brookes, 1980 .

On the nature of the product which results when 7,8-dihydro-7,8-dihydroxybenzo(a)pyrene is metabolised in vitro and bound to DNA.

R. Harvey, E. Tarmy, M. Thompson, 1976, Chemico-biological interactions.

3 – The Interaction of Polycyclic Hydrocarbons with DNA of Mammalian Cells in Culture

M. Osborne, P. Brookes, H. King, 1978 .

EFFECTS OF ALKYLATING AGENTS ON T2 AND T4 BACTERIOPHAGES.

P. D. Lawley, P. Brookes, 1963, The Biochemical journal.

The reaction of trans-7,8-dihydroxy-anti-9,10-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene with DNA involves attack at the N7-position of guanine moieties.

R. Harvey, M. Osborne, P. Brookes, 1978, Chemico-biological interactions.

Reaction of 7-bromomethylbenz(a)anthracene with nucleic acids, polynucleotides, and nucleosides.

A. Dipple, D. Mackintosh, P. Brookes, 1971, Biochemistry.

The in vitro and in vivo reaction at the N7-position of guanine of the ultimate carcinogen derived from benzo[a]pyrene

M. Osborne, P. Brookes, H. King, 1979 .

The preparation and properties of some benzylated nucleosides.

A. Dipple, P. D. Lawley, P. Brookes, 1968, Journal of the Chemical Society. Perkin transactions 1.

Role of Covalent Binding in Carcinogenicity

P. Brookes, 1977 .

Mutagenicity of the carcinogen 7-bromomethylbenz (a)-anthracene: a quantitative study in repair-deficient strains of Escherichia coli.

S. Venitt, E. Tarmy, P. Brookes, 1973, Mutation research.

Acidic Dissociation of 7 : 9-Dialkylguanines and its Possible Relation to Mutagenic Properties of Alkylating Agents

P. D. Lawley, P. Brookes, 1961, Nature.

Cell-mediated mutagenesis in cultured Chinese hamster cells by carcinogenic polycyclic hydrocarbons: nature and extent of the associated hydrocarbon-DNA reaction.

R. Newbold, M. Thompson, C. Wigley, 1977, Mutation research.

Isolation and degradation of DNA from cells treated with tritium-labeled 7,12-dimethylbenz(a)anthracene: studies on the nature of the binding of this carcinogen to DNA.

C. Heidelberger, P. Brookes, 1969, Cancer research.

Methylated bases in liver nucleic acids from rats treated with dimethylnitrosamine

P. Magee, P. D. Lawley, P. Swann, 1968 .

Activated Ki‐ras genes in bladder epithelial cell lines transformed by treatment of primary mouse bladder explant cultures with 7,12‐dimethylbenz[a]anthracene

C. Cooper, I. Summerhayes, W. Warren, 1988, Molecular carcinogenesis.

Studies on the Incorporation of an Unnatural Amino Acid, p-DI-(2-Hydroxy[14C2]Ethyl) Amino-L-Phenylalanine, into Proteins

P. Brookes, 1959, British Journal of Cancer.

Metabolism and macromolecular binding of dibenz(a,c)anthracene and dibenz(a,h)anthracene by mouse embryo cells in culture

M. Duncan, P. Brookes, 1972, International journal of cancer.

The development of resistance to carcinogen-induced cytotoxicity in hamster embryo cultures.

V. Defendi, L. Diamond, P. Brookes, 1968, Experimental cell research.

On the interaction of carcinogens with DNA.

P. Brookes, 1971, Biochemical pharmacology.

Amplification and overexpression of the met gene in spontaneously transformed NIH3T3 mouse fibroblasts.

C. Cooper, C. Heldin, M. Beckman, 1986, The EMBO journal.

On the nature of the mutations induced by the diolepoxide of benzo[a]pyrene in mammalian cells.

P. Brookes, H. King, 1984, Carcinogenesis.

Primary structure of the met protein tyrosine kinase domain.

E. A. Deakin, C. Cooper, A. Chan, 1987, Oncogene.

THE ACTION OF ALKYLATING AGENTS ON DEOXYRIBONUCLEIC ACID IN RELATION TO BIOLOGICAL EFFECTS OF THE ALKYLATING AGENTS.

P. D. Lawley, P. Brookes, 1963, Experimental cell research.

Covalent interaction of carcinogens with DNA.

P. Brookes, 1975, Life sciences.

Lack of oestradiol-DNA binding in mouse embryo cell cultures or following rat-liver microsomal metabolism.

P. Brookes, S. Duncan, 1979, Cancer letters.

4 The relation of Cancer Induction and Genetic Damage

H. Druckrey, P. Brookes, GaryM. Williams, 2016 .

The binding of benzo[α] pyrene to DNA does not involve substitution at the 6-position

R. Harvey, M. Osborne, P. Brookes, 1976 .

The binding to mouse skin DNA of benzo[a]pyrene, its 7,8-diol and 7,8-diol-9,10-epoxides in relation to the tumorigenicity of these compounds.

P. Brookes, 1979, Cancer letters.

International Commission for Protection against Environmental Mutagens and Carcinogens. ICPEMC working paper 2/4: Critical assessment of the value of in vitro cell transformation for predicting in vivo carcinogenicity of chemicals.

P. Brookes, 1981, Mutation research.

The binding of benzo(a)pyrene to DNA components of differing sequence complexity

P. Jack, P. Brookes, 1980, International journal of cancer.

Enzyme activities in extracts of 8-azaguanine-resistant mutants of cultured Chinese hamster cells induced by the carcinogen, 7-bromomethylbenz(a)anthracene.

M. Duncan, P. Brookes, 1974, Mutation research.

Mutation in mammalian cells by isomers of 5-methylchrysene diolepoxide.

R. Harvey, P. Brookes, J. Pataki, 1986, Carcinogenesis.

Field desorption and chemical ionization mass spectra of ‘crown’ and macrobicyclic polyether complexes of potassium

D. Parsons, M. Truter, K. Hall, 1982 .

Action of the carcinogen 7-bromomethylbenz(a)anthracene on DNA.

A. Michelson, F. Pochon, P. Brookes, 1971, European journal of biochemistry.

Activation of the met oncogene in the human MNNG-HOS cell line involves a chromosomal rearrangement.

N. Spurr, B. Reeves, A. Chan, 1986, Carcinogenesis.

The effect of variable serum factors and clonal morphology on the ability to detect hypoxanthine guanine phosphoribosyl transferase (HPRT) deficient variants in cultured Chinese hamster cells

C. Arlett, R. Newbold, B. Bridges, 1975 .

Comparison of the products of the reaction of 7-methylbenz(a)anthracene 5,6-oxide and RNA, with those formed in 7-methylbenz(a)anthracene-treated cells.

W. Baird, P. Grover, P. Sims, 1976, Cancer research.

Pathophysiology of Carcinogenesis in Digestive Organs

P. Brookes, 1978, British Journal of Cancer.

Chemical Mutagens

J. Drake, R. Mortimer, T. Manney, 1971, Springer US.

Chemical Mutagens

J. Drake, J. Crow, R. Mortimer, 1971, Springer US.

On the mechanism of induction of resistance to 6-thioguanine in Chinese hamster V79 cells by 3-methylcholanthrene-diolepoxide.

P. Brookes, H. King, 1985, Carcinogenesis.