H. Dahmen

发表

Inhibition of gp130 Signaling in Breast Cancer Blocks Constitutive Activation of Stat3 and Inhibits in Vivo Malignancy

P. Heinrich, G. Müller-Newen, Li Li, 2004, Cancer Research.

Activation of the signal transducer gp130 by interleukin-11 and interleukin-6 is mediated by similar molecular interactions.

G. Ciliberto, I. Kerr, P. Heinrich, 1998, The Biochemical journal.

Roles in IL-6 Signal Transduction Full-Length Glycoprotein 130 Have Different The Cytoplasmic Tyrosine Motifs in

P. Heinrich, G. Müller-Newen, H. Dahmen, 1999 .

MCT-21-0934 859..870

L. Vassilev, B. Blume, T. Fuchss, 2022 .

Therapeutic targeting of ATR yields durable regressions in small cell lung cancers with high replication stress.

S. Steinberg, J. Khan, Jun S. Wei, 2021, Cancer cell.

A fusion protein of interleukin‐11 and soluble interleukin‐11 receptor acts as a superagonist on cells expressing gp130

P. Heinrich, G. Müller-Newen, J. Grötzinger, 1999, FEBS letters.

Activation of the signal transducer glycoprotein 130 by both IL-6 and IL-11 requires two distinct binding epitopes.

P. Heinrich, G. Müller-Newen, J. Grötzinger, 1999, Journal of immunology.

Signal Transducer Glycoprotein 130 Extracellular Domains for Activation of the Importance of the Membrane-Proximal Tacken

P. Heinrich, I. Kurth, S. Pflanz, 1999 .

Abstract 3500: Highly potent and selective ATM kinase inhibitor M4076: A clinical candidate drug with strong anti-tumor activity in combination therapies

Daniel Kuhn, T. Fuchss, A. Blaukat, 2019, Molecular and Cellular Biology / Genetics.

Reconstitution of two isoforms of the human interleukin-11 receptor and comparison of their functional properties.

P. Heinrich, G. Müller-Newen, M. Hallet, 1997, FEBS letters.

Functional Analysis of Hsp70 Inhibitors

M. Mayer, B. Bukau, D. Musil, 2013, PloS one.

Pharmacologic Inhibitor of DNA-PK, M3814, Potentiates Radiotherapy and Regresses Human Tumors in Mouse Models

L. Vassilev, V. Kirkin, T. Fuchss, 2020, Molecular Cancer Therapeutics.

Abstract 1658: M3814, a novel investigational DNA-PK inhibitor: enhancing the effect of fractionated radiotherapy leading to complete regression of tumors in mice

T. Fuchss, A. Blaukat, U. Pehl, 2016 .

Definition of receptor binding sites on human interleukin-11 by molecular modeling-guided mutagenesis.

P. Heinrich, G. Müller-Newen, S. Minvielle, 1999, European journal of biochemistry.

The Cytoplasmic Tyrosine Motifs in Full-Length Glycoprotein 130 Have Different Roles in IL-6 Signal Transduction1

P. Heinrich, G. Müller-Newen, F. Schaper, 2000, The Journal of Immunology.

Importance of the Membrane-Proximal Extracellular Domains for Activation of the Signal Transducer Glycoprotein 1301

P. Heinrich, G. Müller-Newen, I. Kurth, 2000, The Journal of Immunology.

Constitutive internalization and association with adaptor protein‐2 of the interleukin‐6 signal transducer gp130

P. Heinrich, G. Müller-Newen, F. Schaper, 1998, FEBS letters.

Reconstitution of two isoforms of the human interleukin‐11 receptor and comparison of their functional properties

P. Heinrich, G. Müller-Newen, M. Hallet, 1997 .

A New Class of Selective ATM Inhibitors as Combination Partners of DNA Double-Strand Break Inducing Cancer Therapies

L. Vassilev, B. Blume, T. Fuchss, 2022, Molecular cancer therapeutics.

Abstract 369: Antitumor activity of M4344, a potent and selective ATR inhibitor, in monotherapy and combination therapy

B. Elenbaas, P. Reaper, S. Bagrodia, 2019, Experimental and Molecular Therapeutics.

Selective Inhibition of ATM-dependent Double-strand Break Repair and Checkpoint Control Synergistically Enhances the Efficacy of ATR Inhibitors

L. Vassilev, B. Elenbaas, A. Blaukat, 2023, Molecular cancer therapeutics.

Mapping combinatorial drug effects to DNA damage response kinase inhibitors

Y. Guan, Sven-Eric Schelhorn, Hanrui Zhang, 2023, Nature communications.