Makoto Hamada

发表

Downregulation of CYP1A2, CYP2B6, and CYP3A4 in Human Hepatocytes by Prolyl Hydroxylase Domain 2 Inhibitors via Hypoxia-Inducible Factor-α Stabilization

M. Tada, Sota Kato, Hiroki Takano, 2020, Drug Metabolism and Disposition.

Discovery of novel 2-[(4-hydroxy-6-oxo-2,3-dihydro-1H-pyridine-5-carbonyl)amino]acetic acid derivatives as HIF prolyl hydroxylase inhibitors for treatment of renal anemia.

H. Kakinuma, Sota Kato, Hiroki Takano, 2018, Bioorganic & medicinal chemistry letters.

Novel 3H-[1,2,3]triazolo[4,5-c]pyridine derivatives as GPR119 agonists: Synthesis and structure-activity/solubility relationships.

H. Kakinuma, Noriko Takayama, Fumiyasu Shiozawa, 2017, Bioorganic & medicinal chemistry.

Total synthesis of (-)-kaitocephalin.

T. Shinada, M. Kawasaki, Y. Ohfune, 2005, Organic letters.

Stereoselective Synthesis of (E)‐α,β‐Dehydroamino Acid Esters

T. Shinada, Takeshi Yamada, Y. Ohfune, 2013 .

(7S)-Kaitocephalin as a potent NMDA receptor selective ligand.

T. Shinada, Y. Shigeri, K. Shimamoto, 2016, Organic & biomolecular chemistry.

Efficient total synthesis of (-)-kaitocephalin.

T. Shinada, Y. Ohfune, Makoto Hamada, 2009, Organic letters.

Structure-activity relationship study at C9 position of kaitocephalin.

T. Shinada, Y. Shigeri, K. Shimamoto, 2016, Bioorganic & medicinal chemistry letters.

The Structure of (−)-Kaitocephalin Bound to the Ligand Binding Domain of the (S)-α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA)/Glutamate Receptor, GluA2*

R. Oswald, T. Shinada, Y. Ohfune, 2012, The Journal of Biological Chemistry.

Discovery of Novel Pyrazolylpyridine Derivatives for 20-Hydroxyeicosatetraenoic Acid Synthase Inhibitors with Selective CYP4A11/4F2 Inhibition.

H. Kakinuma, Hiroko Koretsune, Yuji Ito, 2022, Journal of medicinal chemistry.

Design and synthesis of 1H-pyrazolo[3,4-c]pyridine derivatives as a novel structural class of potent GPR119 agonists.

H. Kakinuma, Noriko Takayama, Fumiyasu Shiozawa, 2016, Bioorganic & medicinal chemistry letters.