D. Soncini

发表

SIRT6 inhibitors with salicylate-like structure show immunosuppressive and chemosensitizing effects.

G. Damonte, P. Damonte, S. Bruzzone, 2017, Bioorganic & medicinal chemistry.

Therapy‐induced antitumor vaccination in neuroblastomas by the combined targeting of IL‐2 and TNFα

P. Castellani, B. Carnemolla, R. Accolla, 2010, International journal of cancer.

Nicotinamide phosphoribosyltransferase (NAMPT) inhibitors as therapeutics: rationales, controversies, clinical experience.

S. Bruzzone, F. Montecucco, A. Uccelli, 2013, Current drug targets.

Therapeutic activation of G protein-coupled estrogen receptor 1 in Waldenström Macroglobulinemia

G. Viglietto, N. Munshi, P. Tassone, 2022, Experimental Hematology & Oncology.

Treatment with the CC chemokine-binding protein Evasin-4 improves post-infarction myocardial injury and survival in mice

J. Vallée, F. Mach, F. Montecucco, 2013, Thrombosis and Haemostasis.

Exploiting tumor vulnerabilities: NAD+-depleting agents combined with anti-tumor drugs as innovative strategy to treat hematological malignancies

M. Gobbi, M. Cea, R. Lemoli, 2016, Expert review of anticancer therapy.

Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.

A. Ballestrero, F. Patrone, S. Parodi, 2010, Experimental hematology.

CD73 Protein as a Source of Extracellular Precursors for Sustained NAD+ Biosynthesis in FK866-treated Tumor Cells*

L. Sturla, A. De Flora, S. Bruzzone, 2013, The Journal of Biological Chemistry.

Catastrophic NAD+ Depletion in Activated T Lymphocytes through Nampt Inhibition Reduces Demyelination and Disability in EAE

A. Ballestrero, F. Patrone, E. Moran, 2009, PloS one.

Depletion of SIRT6 enzymatic activity increases acute myeloid leukemia cells’ vulnerability to DNA-damaging agents

M. Gobbi, A. Neri, S. Bruzzone, 2017, Haematologica.

Synthesis and biological characterization of 3-(imidazol-1-ylmethyl)piperidine sulfonamides as aromatase inhibitors.

A. Nencioni, M. Parenti, Federico Andreoli, 2016, Bioorganic & medicinal chemistry letters.

Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma

P. Tassone, A. Neri, M. Manzoni, 2019, Leukemia.

Grb7 Upregulation Is a Molecular Adaptation to HER2 Signaling Inhibition Due to Removal of Akt-Mediated Gene Repression

Mario Passalacqua, Franco Patrone, Vito Pistoia, 2010, PloS one.

NAMPT inhibition results in apoptosis of activated T lymphocytes: evidence for a role of PARP1

A. Ballestrero, P. Damonte, S. Bruzzone, 2014 .

The NAD+-dependent Histone Deacetylase SIRT6 Promotes Cytokine Production and Migration in Pancreatic Cancer Cells by Regulating Ca2+ Responses*

G. Feldmann, A. Ballestrero, F. Patrone, 2012, The Journal of Biological Chemistry.

APO866 Increases Antitumor Activity of Cyclosporin-A by Inducing Mitochondrial and Endoplasmic Reticulum Stress in Leukemia Cells

G. Damonte, A. Ballestrero, F. Patrone, 2015, Clinical Cancer Research.

Dual NAMPT and BTK Targeting Leads to Synergistic Killing of Waldenström Macroglobulinemia Cells Regardless of MYD88 and CXCR4 Somatic Mutation Status

N. Munshi, A. Ballestrero, M. Gobbi, 2016, Clinical Cancer Research.

Synergistic Interactions between HDAC and Sirtuin Inhibitors in Human Leukemia Cells

G. Damonte, A. Ballestrero, F. Patrone, 2011, PloS one.

The new small tyrosine-kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs.

M. Gobbi, A. Neri, B. Schwartz, 2019, Haematologica.

The new small molecule tyrosine-kinase inhibitor ARQ531 targets acute myeloid leukemia cells by disrupting multiple tumor-addicted programs

M. Gobbi, A. Neri, B. Schwartz, 2019 .

CD38-Induced Metabolic Dysfunction Primes Multiple Myeloma Cells for NAD+-Lowering Agents

A. Neri, A. De Flora, S. Bruzzone, 2023, Antioxidants.

Ras-induced resistance to lapatinib is overcome by MEK inhibition.

Silvio Parodi, Franco Patrone, Alberto Ballestrero, 2010, Current cancer drug targets.

EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition

A. Ballestrero, A. Quattrone, S. Indraccolo, 2015, BMC Cancer.

Amino acid depletion triggered by ʟ-asparaginase sensitizes MM cells to carfilzomib by inducing mitochondria ROS-mediated cell death.

M. Zucchetti, A. Neri, S. Bruzzone, 2020, Blood advances.

Fasting potentiates the anticancer activity of tyrosine kinase inhibitors by strengthening MAPK signaling inhibition

A. Ballestrero, P. Damonte, V. Longo, 2015, Oncotarget.

Sirtuin 6 Regulates the Activation of the ATP/Purinergic Axis in Endothelial Cells

A. Balduini, A. De Flora, S. Bruzzone, 2023, International journal of molecular sciences.

Treatment with Angiotensin-(1–7) reduces inflammation in carotid atherosclerotic plaques

N. Stergiopulos, F. Mach, R. Fraga-Silva, 2014, Thrombosis and Haemostasis.

Nicotinamide Phosphoribosyltransferase Promotes Epithelial-to-Mesenchymal Transition as a Soluble Factor Independent of Its Enzymatic Activity*

A. Ballestrero, P. Damonte, S. Bruzzone, 2014, The Journal of Biological Chemistry.

Dynamic simulations of pathways downstream of ERBB-family, including mutations and treatments: concordance with experimental results.

S Parodi, R Pesenti, R. Pesenti, 2010, Current cancer drug targets.

Targeting the deacetylase SIRT6 unveils spliceosome deregulation as exploitable vulnerability for aggressive myeloma

A. Neri, S. Bruzzone, A. Nencioni, 2023, Blood Advances.

Apoptosis reprogramming triggered by splicing inhibitors sensitizes multiple myeloma cells to Venetoclax treatment

N. Munshi, M. Samur, A. Neri, 2021, Haematologica.

Potent synergistic interaction between the Nampt inhibitor APO866 and the apoptosis activator TRAIL in human leukemia cells.

A. Ballestrero, F. Patrone, S. Parodi, 2010, Experimental hematology.

Long non-coding RNA NEAT1 targeting impairs the DNA repair machinery and triggers anti-tumor activity in multiple myeloma

P. Tassone, A. Neri, M. Manzoni, 2019, Leukemia.