S. Bratton

发表

Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis

Sara M. Nowinski, C. U. Lago, J. Rundhaug, 2012, Oncogene.

Caspase-dependent regulation of the ubiquitin–proteasome system through direct substrate targeting

Ting-Chun Yeh, S. Bratton, 2013, Proceedings of the National Academy of Sciences.

Nuclear Factor- (cid:2) B-inducing Kinase (NIK) Contains an Amino-terminal Inhibitor of Apoptosis (IAP)-binding Motif (IBM) That Potentiates NIK Degradation by Cellular IAP1 (c-IAP1) *

C. W. Wright, S. Bratton, Sunhee Lee, 2022 .

Reciprocity in ROS and autophagic signaling.

D. J. Wible, S. Bratton, 2018, Current opinion in toxicology.

Role of hydroquinone-thiol conjugates in benzene-mediated toxicity.

T. Monks, S. Lau, S. Bratton, 2010, Chemico-biological interactions.

Caspase-3 cleaves Apaf-1 into an ∼30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive ∼1.4 MDa apoptosome complex

G. Walker, G. Cohen, K. Cain, 2001, Cell Death and Differentiation.

Caspase cascades in chemically-induced apoptosis.

G. Cohen, S. Bratton, Gerald M. Cohen, 2001, Advances in experimental medicine and biology.

XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders.

J. C. Wilkinson, S. B. Bratton, G. Su, 2006, Molecular cell.

8.20 – Apoptosis☆

S. B. Bratton, D. J. Wible, S. Bratton, 2018 .

The Apaf‐1•procaspase‐9 apoptosome complex functions as a proteolytic‐based molecular timer

Srinivas Malladi, H. Fearnhead, S. Bratton, 2009, The EMBO journal.

Regulation of the intrinsic apoptosis pathway by reactive oxygen species.

Chu-Chiao Wu, S. Bratton, 2013, Antioxidants & redox signaling.

2.28 – Apoptosis

Srinivas Malladi, S. Bratton, Madhavi Challa-Malladi, 2010 .

ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy

D. J. Wible, D. Tang, S. Bratton, 2019, Cell Discovery.

Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis.

G. Cohen, M. MacFarlane, K. Cain, 2000, Experimental cell research.

The Apaf-1 apoptosome: a large caspase-activating complex.

G. Cohen, K. Cain, S. Bratton, 2002, Biochimie.

Proteasome-mediated Degradation of Smac during Apoptosis: XIAP Promotes Smac Ubiquitination in Vitro *

G. Cohen, M. MacFarlane, Marion MacFarlane, 2002, The Journal of Biological Chemistry.

The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities

Srinivas Malladi, Z. Zhang, Miao Chen, 2016, Nature Communications.

The E3 Ubiquitin Ligase cIAP1 Binds and Ubiquitinates Caspase-3 and -7 via Unique Mechanisms at Distinct Steps in Their Processing*

M. Butterworth, G. Cohen, Srinivas Malladi, 2009, Journal of Biological Chemistry.

TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1

S. Varadarajan, S B Bratton, S Varadarajan, 2010, Cell Death and Differentiation.

Intracellular Nucleotides Act as Critical Prosurvival Factors by Binding to Cytochrome C and Inhibiting Apoptosome

H. Fearnhead, V. Gandhi, Angel G. Martín, 2006, Cell.

Bcl-2 and Bcl-xL Inhibit CD95-mediated Apoptosis by Preventing Mitochondrial Release of Smac/DIABLO and Subsequent Inactivation of X-linked Inhibitor-of-Apoptosis Protein*

M. Butterworth, G. Cohen, M. MacFarlane, 2002, The Journal of Biological Chemistry.

XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis

G M Cohen, M. Butterworth, G. Cohen, 2002, Cell Death and Differentiation.

Apoptotic death sensor: an organelle's alter ego?

G. Cohen, S. Bratton, 2001, Trends in pharmacological sciences.

Recruitment, activation and retention of caspases‐9 and ‐3 by Apaf‐1 apoptosome and associated XIAP complexes

S. B. Bratton, G. Walker, S. Srinivasula, 2001, The EMBO journal.

Uncoupling of the Signaling and Caspase-inhibitory Properties of X-linked Inhibitor of Apoptosis*

Stephanie Birkey Reffey, S. B. Bratton, A. Roberts, 2004, Journal of Biological Chemistry.

The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis.

J. Richburg, Jessica L. Myers, S. Bratton, 2014, Seminars in cell & developmental biology.

Apaf-1 Oligomerizes into Biologically Active ∼700-kDa and Inactive ∼1.4-MDa Apoptosome Complexes*

Gail Walker, G. Walker, G. Cohen, 2000, The Journal of Biological Chemistry.

Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes.

G M Cohen, C Langlais, K Cain, 2000, The Journal of biological chemistry.

Identification of quinol thioethers in bone marrow of hydroquinone/phenol-treated rats and mice and their potential role in benzene-mediated hematotoxicity.

T. Monks, S. Lau, S. Bratton, 1997, Chemical research in toxicology.

Regulation of the Apaf-1–caspase-9 apoptosome

G. Salvesen, Guy S Salvesen, Shawn B Bratton, 2010, Journal of Cell Science.

Death receptors leave a caspase footprint that Smacs of XIAP

G. Cohen, S. Bratton, 2003, Cell Death and Differentiation.

BH3-Only Protein BIM Mediates Heat Shock-Induced Apoptosis

S. B. Bratton, I. M. Mahajan, Miao Chen, 2014, PloS one.

Peptide inhibitors: Four of a kind beats a pair.

S. Bratton, 2012, Nature chemical biology.

Drosophila Omi, a mitochondrial‐localized IAP antagonist and proapoptotic serine protease

Srinivas Malladi, K. White, S. Varadarajan, 2007, The EMBO journal.

Heat Shock Induces Apoptosis Independently of Any Known Initiator Caspase-activating Complex*

S. Bratton, R. Milleron, Rania S. Milleron, 2006, Journal of Biological Chemistry.

Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis

Sara M. Nowinski, C. U. Lago, J. Rundhaug, 2015, Nature Communications.

Caspase-9 swings both ways in the apoptosome

S. B. Bratton, Chu-Chiao Wu, S. Bratton, 2017, Molecular & cellular oncology.

‘Heated’ Debates in Apoptosis

S. Bratton, R. Milleron, Rania S. Milleron, 2007, Cellular and Molecular Life Sciences.

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

K. Dalby, D. J. Wible, S. Mukhopadhyay, 2023, bioRxiv.

Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c.

Srinivas Malladi, T. Monks, S. Lau, 2007, Biochemistry.

Does ATP promote or protect cells from apoptosis?

H. Fearnhead, V. Gandhi, Angel G. Martín, 2006 .

The putative benzene metabolite 2,3, 5-tris(glutathion-S-yl)hydroquinone depletes glutathione, stimulates sphingomyelin turnover, and induces apoptosis in HL-60 cells.

T. Monks, S. Lau, S. Bratton, 2000, Chemical research in toxicology.

Novel Localization of NMDA Receptors Within Neuroendocrine Gonadotropin-Releasing Hormone Terminals

J. Morrison, J. Mendenhall, W. Janssen, 2007, Experimental biology and medicine.

Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex.

G. Walker, G. Cohen, K. Cain, 2001, Cell death and differentiation.

ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy

D. J. Wible, D. Tang, Hsueh-Ping Chao, 2019, Cell Discovery.

The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation.

Srinivas Malladi, T. Monks, S. Lau, 2011, Toxicological sciences : an official journal of the Society of Toxicology.

DrICE resurrects Grim to antagonize DIAP1

Ting-Chun Yeh, S. Bratton, 2014, Cell cycle.

Regulation of the intrinsic apoptosis pathway by reactive oxygen species.

Chu-Chiao Wu, S. Bratton, 2013, Antioxidants & redox signaling.

Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control

K. Dalby, D. J. Wible, Collene R. Jeter, 2024, Cell death & disease.

Caspase-9 swings both ways in the apoptosome

Chu-Chiao Wu, S. Bratton, 2017, Molecular & cellular oncology.