Jamie Young

发表

Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia

U. McDermott, S. Price, M. Ashcroft, 2021, Communications biology.

Cadmium chloride, benzo[a]pyrene and cyclophosphamide tested in the in vitro mammalian cell micronucleus test (MNvit) in the human lymphoblastoid cell line TK6 at Covance laboratories, Harrogate UK in support of OECD draft Test Guideline 487.

D. Kirkland, P. Fowler, Katie Smith, 2010, Mutation research.

Preclinical characterization of the CDK4/6 inhibitor LY2835219: in-vivo cell cycle-dependent/independent anti-tumor activities alone/in combination with gemcitabine

P. Iversen, L. Gelbert, Concha Sánchez-Martínez, 2014, Investigational New Drugs.

Genome-wide chemical mutagenesis screens allow unbiased saturation of the cancer genome and identification of drug resistance mutations

M. Stratton, L. Stebbings, G. Bignell, 2017, bioRxiv.

Genome-wide CRISPR/Cas9 deletion screen defines mitochondrial gene essentiality and identifies routes for tumour cell viability in hypoxia

S. Price, M. Ashcroft, R. Morgan, 2021, Communications Biology.

Abstract B233: Identification and characterization of LY2835219: A potent oral inhibitor of the cyclin-dependent kinases 4 and 6 (CDK4/6) with broad in vivo antitumor activity.

L. Gelbert, Concha Sánchez-Martínez, B. Neubauer, 2011 .

Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. I. Choice of cell type.

Katie Smith, David Kirkland, Stefan Pfuhler, 2012, Mutation research.

Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. II. Importance of accurate toxicity measurement.

Katie Smith, David Kirkland, Stefan Pfuhler, 2012, Mutation research.

Reduction of misleading ("false") positive results in mammalian cell genotoxicity assays. III: sensitivity of human cell types to known genotoxic agents.

Katie Smith, David Kirkland, Stefan Pfuhler, 2014, Mutation research. Genetic toxicology and environmental mutagenesis.

Etoposide; colchicine; mitomycin C and cyclophosphamide tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster lung (CHL) cells at Covance laboratories; Harrogate UK in support of OECD draft Test Guideline 487.

D. Kirkland, P. Fowler, Katie Smith, 2010, Mutation research.

5-Fluorouracil, colchicine, benzo[a]pyrene and cytosine arabinoside tested in the in vitro mammalian cell micronucleus test (MNvit) in Chinese hamster V79 cells at Covance Laboratories, Harrogate, UK in support of OECD draft Test Guideline 487.

D. Kirkland, P. Fowler, Katie Smith, 2010, Mutation research.