Haoyu Ye

发表

Synthesis, structure-activity relationships and biological evaluation of barbigerone analogues as anti-proliferative and anti-angiogenesis agents.

Yuquan Wei, F. Wang, Mingli Xiang, 2014, Bioorganic & medicinal chemistry letters.

Herb-sourced emodin inhibits angiogenesis of breast cancer by targeting VEGFA transcription

Longlong Wang, Jin Zhao, R. Xiang, 2020, Theranostics.

Non-toxic dose of liposomal honokiol suppresses metastasis of hepatocellular carcinoma through destabilizing EGFR and inhibiting the downstream pathways

Yuquan Wei, X. Shao, Heying Pei, 2016, Oncotarget.

Studies on the anti-psoriasis effects and its mechanism of a dual JAK2/FLT3 inhibitor flonoltinib maleate.

P. Lin, Zhuang Yang, Ming-hai Tang, 2021, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

New Highly Potent NLRP3 Inhibitors: Furanochalcone Velutone F Analogues.

Ming-hai Tang, Lijuan Chen, Wenshuang Wu, 2022, ACS medicinal chemistry letters.

Structure-Based Design and Synthesis of N-Substituted 3-Amino-β-Carboline Derivatives as Potent αβ-Tubulin Degradation Agents.

Yan Liu, Zhuang Yang, Ming-hai Tang, 2022, Journal of medicinal chemistry.

Discovery of a Series of Hydroxamic Acid-Based Microtubule Destabilizing Agents with Potent Antitumor Activity.

Yan Liu, Zhuang Yang, Ming-hai Tang, 2021, Journal of medicinal chemistry.

Design, synthesis, and structure-activity relationship studies of novel millepachine derivatives as potent antiproliferative agents.

Yuquan Wei, X. Liang, Liang Ma, 2012, European journal of medicinal chemistry.

Enrichment and isolation of barbigerone from Millettia pachycarpa Benth. using high-speed counter-current chromatography and preparative HPLC.

Ming-hai Tang, A. Peng, Li-juan Chen, 2010, Journal of separation science.

Synthesis, activity, and docking study of phenylthiazole acids as potential agonists of PPARγ

Liang Ma, Taijin Wang, Min Shi, 2016, Drug design, development and therapy.

Deguelin—An inhibitor to tumor lymphangiogenesis and lymphatic metastasis by downregulation of vascular endothelial cell growth factor‐D in lung tumor model

Yuquan Wei, A. Fu, Li-juan Chen, 2010, International journal of cancer.

Alkaloids from Black Pepper (Piper nigrum L.) Exhibit Anti-inflammatory Activity in Murine Macrophages by Inhibiting Activation of NF-κB Pathway.

Ming-hai Tang, Heying Pei, Lijuan Chen, 2020, Journal of agricultural and food chemistry.

Small Molecules Promote Selective Denaturation and Degradation of Tubulin Heterodimers through a Low-Barrier Hydrogen Bond.

Dingguo Xu, L. Ouyang, Heying Pei, 2022, Journal of medicinal chemistry.

Rapid separation and identification of major constituents in Pseudolarix kaempferi by ultra-performance liquid chromatography coupled with electrospray and quadrupole time-of-flight tandem mass spectrometry.

Liang Ma, Ming-hai Tang, A. Peng, 2009, Rapid communications in mass spectrometry : RCM.

Synthesis and discovery of new compounds bearing coumarin scaffold for the treatment of pulmonary fibrosis.

Zhuang Yang, Ming-hai Tang, Heying Pei, 2019, European journal of medicinal chemistry.

Millepachine showed novel antitumor effects in cisplatin‐resistant human ovarian cancer through inhibiting drug efflux function of ATP‐binding cassette transporters

Wenshuang Wu, Zhihui Li, Yang Liu, 2018, Phytotherapy research : PTR.

Identification of Pyrrolo[2,3- d]pyrimidine-Based Derivatives as Potent and Orally Effective Fms-like Tyrosine Receptor Kinase 3 (FLT3) Inhibitors for Treating Acute Myelogenous Leukemia.

Yuquan Wei, Sheng-yong Yang, Mingli Xiang, 2019, Journal of Medicinal Chemistry.

Metabolic profiling in liver microsomes and mice of E28, a potent FLT3 inhibitor

Ming-hai Tang, Yan Tan, Yong Chen, 2022, Xenobiotica; the fate of foreign compounds in biological systems.

Sample injection strategy to increase throughput in counter-current chromatography: Case study of Honokiol purification.

S. Ignatova, I. Sutherland, L. Zu, 2016, Journal of chromatography. A.

SKLB060 Reversibly Binds to Colchicine Site of Tubulin and Possesses Efficacy in Multidrug-Resistant Cell Lines

Yiguo Hu, Sheng-yong Yang, Peng Bai, 2018, Cellular Physiology and Biochemistry.

Covalent modification of Cys-239 in β-tubulin by small molecules as a strategy to promote tubulin heterodimer degradation

Yong Li, Lijuan Chen, Weimin Li, 2019, The Journal of Biological Chemistry.

The compound millepachine and its derivatives inhibit tubulin polymerization by irreversibly binding to the colchicine-binding site in β-tubulin

T. Yang, F. Wang, Heying Pei, 2018, The Journal of Biological Chemistry.

Honokiol Metabolites Study in Rat Kidney Employing UHPLC-Q-TOF/MS and 13C Stable Isotope Labeling

Ming-hai Tang, Neng Qiu, Li-juan Chen, 2015, Chromatographia.

Flavonoids from the stems of Millettia pachyloba Drake mediate cytotoxic activity through apoptosis and autophagy in cancer cells

Ming-hai Tang, Lijuan Chen, Huan Tang, 2019, Journal of advanced research.

Intermittent counter-current extraction as an alternative approach to purification of Chinese herbal medicine.

S. Ignatova, I. Sutherland, Li-juan Chen, 2009, Journal of chromatography. A.

Preparative separation of a terpenoid and alkaloids from Tripterygium wilfordii Hook. f. using high-performance counter-current chromatography. Comparison of various elution and operating strategies.

S. Ignatova, I. Sutherland, A. Peng, 2008, Journal of chromatography. A.

Preparative isolation and purification of three rotenoids and one isoflavone from the seeds of Millettia pachycarpa Benth by high-speed counter-current chromatography.

Yuquan Wei, Hang Song, Ming-hai Tang, 2008, Journal of chromatography. A.

Bioactivity-guided isolation of anti-inflammation flavonoids from the stems of Millettia dielsiana Harms.

Shucai Li, Ming-hai Tang, Lijuan Chen, 2014, Fitoterapia.

Synthesis, Activity, and Docking Study of Novel Phenylthiazole‐Carboxamido Acid Derivatives as FFA2 Agonists

Liang Ma, Heying Pei, P. Fu, 2016, Chemical biology & drug design.

Identification of the target protein and molecular mechanism of honokiol in anti-inflammatory action.

Ming-hai Tang, Lijuan Chen, Wenshuang Wu, 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Comparison of counter-current chromatography and preparative high performance liquid chromatography applied to separating minor impurities in drug preparations.

Kai Chen, Shucai Li, Lijuan Chen, 2014, Journal of chromatography. A.

Anti-inflammatory activity of ethyl acetate fraction of the seeds of Brucea Javanica.

Shucai Li, Huan Tang, A. Peng, 2013, Journal of ethnopharmacology.

Two new triterpenoids from the stems of Celastrus orbiculatus Thunb

Huan Tang, L. Ma, Linlin Xue, 2018, Phytochemistry Letters.

Discovery and synthesis of novel magnolol derivatives with potent anticancer activity in non-small cell lung cancer.

Ming-hai Tang, Lijuan Chen, Huan Tang, 2018, European journal of medicinal chemistry.

Millepachine, a novel chalcone, induces G2/M arrest by inhibiting CDK1 activity and causing apoptosis via ROS-mitochondrial apoptotic pathway in human hepatocarcinoma cells in vitro and in vivo.

Yuquan Wei, Zhu Yuan, Heying Pei, 2013, Carcinogenesis.

Synthesis and biological evaluation of novel pyranochalcone derivatives as a new class of microtubule stabilizing agents.

X. Liang, Mingli Xiang, Liang Ma, 2013, European journal of medicinal chemistry.

Structural exploration, synthesis and pharmacological evaluation of novel 5-benzylidenethiazolidine-2,4-dione derivatives as iNOS inhibitors against inflammatory diseases.

X. Liang, Mingli Xiang, Liang Ma, 2015, European journal of medicinal chemistry.

Biphenyl-type neolignans from stem bark of Magnolia officinalis with potential anti-tumor activity.

Lijuan Chen, X. Qiu, Li Wan, 2020, Fitoterapia.

Identification, characterization and HPLC quantification of formulation‐related impurities of honokiol, an antitumor natural drug candidate in clinical trials

Lijuan Chen, Huan Tang, A. Peng, 2018, Journal of pharmaceutical and biomedical analysis.

Separation of flavonoids from Millettia griffithii with high-performance counter-current chromatography guided by anti-inflammatory activity.

Liang Ma, Heying Pei, Huan Tang, 2015, Journal of separation science.

Cytotoxic and apoptotic effects of constituents from Millettia pachycarpa Benth.

Shucai Li, Ming-hai Tang, A. Fu, 2012, Fitoterapia.

Separation of anthraquinone compounds from the seed of Cassia obtusifolia L. using recycling counter-current chromatography.

Shucai Li, A. Peng, Li-juan Chen, 2012, Journal of separation science.

Phytochemical investigation of Millettia dorwardi Coll. et Hemsl

Shucai Li, Lijuan Chen, Huan Tang, 2015 .

Identification of compounds with cytotoxic activity from Millettia dorwardi Coll. Et. Hemsl

Ming-hai Tang, Huan Tang, A. Peng, 2018, Phytochemistry Letters.

Separation of caffeoylquinic acids and flavonoids from Asteris souliei by high-performance counter-current chromatography and their anti-inflammatory activity in vitro.

Ming-hai Tang, Heying Pei, Huan Tang, 2017, Journal of separation science.

Flow rate gradient high-speed counter-current chromatography separation of five diterpenoids from Triperygium wilfordii and scale-up.

Rui Li, Lijuan Chen, Xia Zhao, 2008, Journal of chromatography. A.

Preparative purification of anti-tumor derivatives of honokiol by high-speed counter-current chromatography.

Yuquan Wei, Cheng Peng, Sheng-yong Yang, 2008, Journal of chromatography. A.

Purification of honokiol derivatives from one-pot synthesis by high-performance counter-current chromatography.

Yuquan Wei, Shucai Li, Youfu Luo, 2010, Journal of chromatography. A.

Application of step-wise gradient high-performance counter-current chromatography for rapid preparative separation and purification of diterpene components from Pseudolarix kaempferi Gordon.

Cheng Peng, Yongkui Zhang, Hang Song, 2012, Journal of chromatography. A.

Separation of honokiol and magnolol by intermittent counter-current extraction.

Shucai Li, A. Peng, Li-juan Chen, 2010, Journal of chromatography. A.

Using High-Performance Counter-Current Chromatography Combined with Preparative High Performance Liquid Chromatogramphy for the Separation of Bioactive Compounds from the Water Extract of Gentiana macrophylla Pall

Shucai Li, Ming-hai Tang, A. Peng, 2012 .

Predictable and linear scale-up of four phenolic alkaloids separation from the roots of Menispermum dauricum using high-performance counter-current chromatography.

Ming-hai Tang, A. Peng, Li-juan Chen, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Preparative separation of capsaicin and dihydrocapsaicin from Capsicum frutescens by high-speed counter-current chromatography.

A. Peng, Li-juan Chen, Xia Li, 2009, Journal of separation science.

Elution-extrusion counter-current chromatography separation of five bioactive compounds from Dendrobium chrysototxum Lindl.

Shucai Li, A. Peng, Li-juan Chen, 2011, Journal of chromatography. A.

Preparative isolation and purification of anti-tumor agent ansamitocin P-3 from fermentation broth of Actinosynnema pretiosum using high-performance counter-current chromatography.

Yuquan Wei, Luoting Yu, Ming-hai Tang, 2010, Journal of separation science.

Optimising resolution for a preparative separation of Chinese herbal medicine using a surrogate model sample system.

S. Ignatova, I. Sutherland, A. Peng, 2009, Journal of chromatography. A.

Identification of metabolites of honokiol in rat urine using 13C stable isotope labeling and liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry.

Liang Ma, Ming-hai Tang, Lulu Cai, 2013, Journal of chromatography. A.

Liposomal honokiol induced lysosomal degradation of Hsp90 client proteins and protective autophagy in both gefitinib-sensitive and gefitinib-resistant NSCLC cells.

F. Wang, Sheng-yong Yang, Ming-hai Tang, 2017, Biomaterials.

13C stable isotope labeling followed by ultra-high performance liquid chromatography/quadrupole time-of-flight tandem mass spectrometry (UHPLC/Q-TOF MS) was applied to identify the metabolites of honokiol in rat small intestines

Ming-hai Tang, Na Ye, Li-juan Chen, 2015 .

Characterization of metabolic profile of honokiol in rat feces using liquid chromatography coupled with quadrupole time-of-flight tandem mass spectrometry and (13)C stable isotope labeling.

Yuquan Wei, Yongkui Zhang, Hang Song, 2014, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Coumarinolignans Isolated from the Seeds of Brucea javanica

Shucai Li, Huan Tang, A. Peng, 2014 .

Rational design, synthesis, and pharmacological properties of pyranochalcone derivatives as potent anti-inflammatory agents.

Yuquan Wei, X. Liang, Mingli Xiang, 2012, European journal of medicinal chemistry.

Barbigerone, an isoflavone, inhibits tumor angiogenesis and human non-small-cell lung cancer xenografts growth through VEGFR2 signaling pathways

A. Peng, Li-juan Chen, Xuewei Wang, 2012, Cancer Chemotherapy and Pharmacology.

Purinostat Mesylate Is a Uniquely Potent and Selective Inhibitor of HDACs for the Treatment of BCR-ABL–Induced B-Cell Acute Lymphoblastic Leukemia

Fang Wang, Yiguo Hu, Zhuang Yang, 2019, Clinical Cancer Research.

The Natural Compound Withaferin A Covalently Binds to Cys239 of β-Tubulin to Promote Tubulin Degradation

Yong Li, Lijuan Chen, Wei-Qun Yan, 2019, Molecular Pharmacology.

Barbigerone reverses multidrug resistance in breast MCF‐7/ADR cells

Heying Pei, Lijuan Chen, Li-sheng Zheng, 2018, Phytotherapy research : PTR.

Ethanol extract of Liriodendron chinense (Hemsl.) Sarg barks attenuates hyperuricemic nephropathy by inhibiting renal fibrosis and inflammation in mice.

Ming-hai Tang, P. Fu, Jing Liu, 2020, Journal of ethnopharmacology.

Honokiol Ameliorates Post-Myocardial Infarction Heart Failure Through Ucp3-Mediated Reactive Oxygen Species Inhibition

Yan Liu, Heying Pei, Lijuan Chen, 2022, Frontiers in Pharmacology.

Characterization of In Vivo Metabolites of a Potential Anti-obesity Compound, the 3-Methyl-1H-Purine-2,6-Dione Derivative C-11, Employing Ultra-High Performance Liquid Chromatography Coupled with Quadrupole Time-of-Flight Mass Spectrometry

Liang Ma, Ming-hai Tang, Neng Qiu, 2016, Chromatographia.

Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson's disease via the activation of Nrf2/keap1 pathway.

Lijuan Chen, Mingsong Shi, Linlin Xue, 2020, European journal of medicinal chemistry.

MAPK‐Targeted Drug Delivered by a pH‐Sensitive MSNP Nanocarrier Synergizes with PD‐1 Blockade in Melanoma without T‐Cell Suppression

Hubing Shi, Jie Xu, Huan Meng, 2019, Advanced Functional Materials.

Millepachine, a potential topoisomerase II inhibitor induces apoptosis via activation of NF-κB pathway in ovarian cancer

Yuquan Wei, Lijuan Chen, Buyun Ma, 2016, Oncotarget.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Yuquan Wei, L. Ouyang, Zhuang Yang, 2020, Science Advances.

Preclinical studies of Flonoltinib Maleate, a novel JAK2/FLT3 inhibitor, in treatment of JAK2V617F-induced myeloproliferative neoplasms

T. Yang, Zhuang Yang, Ming-hai Tang, 2022, Blood Cancer Journal.

An isoflavone derivative potently inhibits the angiogenesis and progression of triple-negative breast cancer by targeting the MTA2/SerRS/VEGFA pathway

Longlong Wang, Jin Zhao, R. Xiang, 2020, Cancer biology & medicine.

In Vitro and In Vivo Primary Metabolic Characterization of F18, a Novel Histone Deacetylase-6 (HDAC6) Inhibitor, Using UHPLC–QqQ–MS/MS and Q-TOF–MS Methods

Liang Ma, Ming-hai Tang, Li-juan Chen, 2016, Chromatographia.

Isogambogenic acid induces apoptosis-independent autophagic cell death in human non-small-cell lung carcinoma cells

Yuquan Wei, Shucai Li, Heying Pei, 2015, Scientific Reports.

Millettia pachycarpa exhibits anti-inflammatory activity through the suppression of LPS-induced NO/iNOS expression.

Shucai Li, Ming-hai Tang, Huan Tang, 2014, The American journal of Chinese medicine.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin and provides insights into microtubule dynamic instability

Yuquan Wei, L. Ouyang, Zhuang Yang, 2020, bioRxiv.

Design, synthesis and discovery of 2(1H)-quinolone derivatives for the treatment of pulmonary fibrosis through inhibition of TGF-β/smad dependent and independent pathway.

Zhuang Yang, Ming-hai Tang, Heying Pei, 2020, European journal of medicinal chemistry.

From lead to clinic: A review of the structural design of P2X7R antagonists.

Wenshuang Wu, Ruijia Zhang, Na Li, 2023, European journal of medicinal chemistry.

Design, Synthesis, and Bioactivity Evaluation of Dual-Target Inhibitors of Tubulin and Src Kinase Guided by Crystal Structure.

Ming-hai Tang, Lijuan Chen, Wei-Qun Yan, 2021, Journal of medicinal chemistry.

Discovery of pyrimidine-5-carboxamide derivatives as novel salt-inducible kinases (SIKs) inhibitors for inflammatory bowel disease (IBD) treatment.

Nannan Li, Lijuan Chen, Mingsong Shi, 2023, European journal of medicinal chemistry.

A new role of low barrier hydrogen bond in mediating protein stability by small molecules

Yuquan Wei, Dingguo Xu, L. Ouyang, 2021, bioRxiv.

Characterization of in vitro primary metabolic profile of SKLB-M8, a novel antitumor compound, using liquid chromatography coupled with triple quadrupole tandem mass spectrometry and quadrupole time-of-flight tandem mass spectrometry

Ming-hai Tang, Neng Qiu, Li-juan Chen, 2015 .

Reversible binding of the anticancer drug KXO1 (tirbanibulin) to the colchicine-binding site of β-tubulin explains KXO1's low clinical toxicity

Lijuan Chen, Wei-Qun Yan, Yamei Yu, 2019, The Journal of Biological Chemistry.

UPLC-MS/MS method development and application to pharmacokinetic study in rats and dogs of Flonoltinib Maleat.

Zhuang Yang, Qianlun Pu, Yanting Zhou, 2023, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Design and synthesis of 1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles and pyrazolo[3,4-b]pyridines for Aurora-A kinase inhibitors.

Yuquan Wei, Sheng-yong Yang, Youfu Luo, 2010, Bioorganic & Medicinal Chemistry Letters.

SKLB-23bb, A HDAC6-Selective Inhibitor, Exhibits Superior and Broad-Spectrum Antitumor Activity via Additionally Targeting Microtubules

Yuquan Wei, Yiguo Hu, F. Wang, 2018, Molecular Cancer Therapeutics.

Enhancement of therapeutic effectiveness by combining liposomal honokiol with cisplatin in ovarian carcinoma

Z. Li, Xia Zhao, X. Lin, 2007, International Journal of Gynecologic Cancer.

The effect and mechanism of millepachine-disrupted spindle assembly in tumor cells

Wenshuang Wu, A. Su, Jingqiang Zhu, 2018, Anti-Cancer Drugs.

Discovery and synthesis of novel magnolol derivatives with potent anticancer activity in non-small cell lung cancer.

Ming-hai Tang, Lijuan Chen, Huan Tang, 2018, European journal of medicinal chemistry.

Cevipabulin-tubulin complex reveals a novel agent binding site on α-tubulin with tubulin degradation effect

Yuquan Wei, Zhuang Yang, Ming-hai Tang, 2021, Science Advances.