P. Ayton

发表

Differential expression of the topoisomerase II alpha and beta genes in human breast cancers.

A. Harris, H. Turley, D. Hochhauser, 1996, British Journal of Cancer.

Dimerization contributes to oncogenic activation of MLL chimeras in acute leukemias.

M. Cleary, C. So, P. Ayton, 2003, Cancer cell.

Isolation of cDNA clones encoding the beta isozyme of human DNA topoisomerase II and localisation of the gene to chromosome 3p24.

A. Harris, D. Sheer, J. Jenkins, 1992, Nucleic acids research.

A novel class of zinc finger/leucine zipper genes identified from the molecular cloning of the t(10;11) translocation in acute leukemia.

R. Berger, V. D. Valle, V. Della Valle, 1995, Blood.

Similar MLL-associated leukemias arising from self-renewing stem cells and short-lived myeloid progenitors.

I. Weissman, E. Passegué, M. Cleary, 2003, Genes & development.

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties.

M. Cleary, M. Ohki, I. Kitabayashi, 2002, Blood.

Molecular mechanisms of leukemogenesis mediated by MLL fusion proteins

M. Cleary, P. Ayton, 2001, Oncogene.

Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9.

M. Cleary, Michael L Cleary, Paul M Ayton, 2003, Genes & development.

MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP.

J. Kutok, C. Glass, M. Cleary, 2003, Cancer cell.

Binding to Nonmethylated CpG DNA Is Essential for Target Recognition, Transactivation, and Myeloid Transformation by an MLL Oncoprotein

M. Cleary, P. Ayton, E. Chen, 2004, Molecular and Cellular Biology.

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

M. Cleary, B. Young, C. Naftzger, 2002, Blood.

A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.

A. Shilatifard, J. Hess, M. Cleary, 2000, Blood.

progenitors by MLL-AF10 The AF10 leucine zipper is required for leukemic transformation of myeloid

B. Young, L. Michael, C. Naftzger, 2013 .

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.

Kevin S. Smith, M. Liedtke, M. Cleary, 2010, Blood.

The leukemia-associated-protein (LAP) domain, a cysteine-rich motif, is present in a wide range of proteins, including MLL, AF10, and MLLT6 proteins.

V. Saha, B. Young, T. Chaplin, 1995, Proceedings of the National Academy of Sciences of the United States of America.

MLL in Normal and Malignant Hematopoiesis

M. Cleary, P. Ayton, 2002 .

Truncation of the MLL gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos

M. Owen, I. Rosewell, B. Young, 2001, Genesis.