J. Fischer

发表

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity.

J. Blake, J. Christensen, B. Brandhuber, 2018, ACS medicinal chemistry letters.

Non-nucleoside inhibitors of HCV NS5B polymerase. Part 1: Synthetic and computational exploration of the binding modes of benzothiadiazine and 1,4-benzothiazine HCV NS5b polymerase inhibitors.

J. E. Robinson, J. Blake, S. Le Pogam, 2009, Bioorganic & medicinal chemistry letters.

Differential induction of cytochrome P-450 catalyzed activities by polychlorinated biphenyls and benzo [a]pyrene in B6C3F1 mouse liver and lung.

C. Mitchell, A. Dahl, J. Fischer, 1987, Toxicology.

Identification of the Clinical Development Candidate MRTX849, a Covalent KRASG12C Inhibitor for the Treatment of Cancer

J. Blake, J. Christensen, G. Vigers, 2020 .

Discovery and preclinical development of AR453588 as an anti-diabetic glucokinase activator.

Ashutosh Kumar Singh, F. Sullivan, E. Wallace, 2019, Bioorganic & medicinal chemistry.

Neuroprotective effects of erythropoietin on acute metabolic and pathological changes in experimentally induced neurotrauma Laboratory investigation

Shengle Zhang, J. Strauss, Sejal Shah, 2008 .

Identification of a novel 3,5-disubstituted pyridine as a potent, selective, and orally active inhibitor of Akt1 kinase.

Eric F. Johnson, X. Liu, V. Giranda, 2006, Bioorganic & medicinal chemistry letters.

Synthesis and SAR of indazole-pyridine based protein kinase B/Akt inhibitors.

Eric F. Johnson, X. Liu, V. Giranda, 2006, Bioorganic & medicinal chemistry.

Galanthamine: pharmacokinetics, tissue distribution and cholinesterase inhibition in brain of mice

W. Weber, T. Thomsen, U. Bickel, 1991, Neuropharmacology.

955 PRECLINICAL POTENCY, PHARMACOKINETIC AND ADME CHARACTERIZATION OF ABT-333, A NOVEL NON-NUCLEOSIDE HCV POLYMERASE INHIBITOR

A. Molla, D. Beno, C. Flentge, 2009 .

Effect of the cholinesterase inhibiting substance galanthamine on human EEG and visual evoked potentials.

G. Holl, T. Thomsen, M Straschill, 1992, Electroencephalography and clinical neurophysiology.

Identification of MRTX1133, a Noncovalent, Potent, and Selective KRASG12D Inhibitor.

J. Blake, J. Christensen, J. Lawson, 2021, Journal of medicinal chemistry.

The KRASG12C Inhibitor, MRTX849, Provides Insight Toward Therapeutic Susceptibility of KRAS Mutant Cancers in Mouse Models and Patients.

J. Fernandez-Banet, A. Pavlícek, J. Christensen, 2019, Cancer discovery.

Stereoselectivity of cholinesterase inhibition by galanthamine and tolerance in humans

T. Thomsen, U. Bickel, J. Fischer, 2004, European Journal of Clinical Pharmacology.

In vitro effects of various cholinesterase inhibitors on acetyl- and butyrylcholinesterase of healthy volunteers.

T. Thomsen, J. Fischer, H. Kewitz, 1991, Biochemical pharmacology.

The effect of molecular weight/lipophilicity on clearance of organic compounds from lungs.

R. Henderson, W. Bechtold, M. Medinsky, 1988, Toxicology and applied pharmacology.

A nano-scale barrel and cube: transition metal-mediated self-assembly of CpCoCb-derived ligand scaffolds.

A. E. Counterman, D. Clemmer, R. Brisbois, 2001, Journal of the American Chemical Society.

Inhibition of Acetylcholinesterase Activity in Human Brain Tissue and Erythrocytes by Galanthamine, Physostigmine and Tacrine

H. Barz, T. Thomsen, U. Bickel, 1991, European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies.

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 4: structure-based design, synthesis, and biological evaluation of benzo[d]isothiazole-1,1-dioxides.

April Wong, J. E. Robinson, Jim Li, 2009, Bioorganic & medicinal chemistry letters.

Synthesis and inhibitory properties of α(chlorofluoromethyl)-α-amino acids, a novel class of irreversible inactivators of decarboxylases

A. Mitschler, D. Schirlin, A. Cian, 1992 .

Neuroprotective effects of erythropoietin on acute metabolic and pathological changes in experimentally induced neurotrauma.

Shengle Zhang, J. Strauss, J. Fischer, 2008, Journal of neurosurgery.

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 3: synthesis and optimization studies of benzothiazine-substituted tetramic acids.

J. E. Robinson, J. Blake, C. Oshiro, 2009, Bioorganic & medicinal chemistry letters.

Non-nucleoside inhibitors of HCV polymerase NS5B. Part 2: Synthesis and structure-activity relationships of benzothiazine-substituted quinolinediones.

J. E. Robinson, J. Blake, C. Oshiro, 2009, Bioorganic & medicinal chemistry letters.