Saundra Clausen

Pyridones as Highly Selective, Noncovalent Inhibitors of T790M Double Mutants of EGFR.

C. Eigenbrot, Ivana Yen, S. Sideris, 2016, ACS medicinal chemistry letters.

Small Molecule Dysregulation of TEAD Lipidation Induces a Dominant-Negative Inhibition of Hippo Pathway Signaling.

Christian N. Cunningham, P. Beroza, Rohit Reja, 2020, Cell reports.

Inhibition of native hepatitis C virus replicase by nucleotide and non-nucleoside inhibitors.

N. Cammack, K. Klumpp, Weixing Li, 2005, Virology.

Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.

Siew K. Yeap, M. Ultsch, C. Eigenbrot, 2022, Journal of medicinal chemistry.

Discovery of a Noncovalent, Mutant-Selective Epidermal Growth Factor Receptor Inhibitor.

Siew K. Yeap, C. Eigenbrot, Ivana Yen, 2016, Journal of medicinal chemistry.

Noncovalent Mutant Selective Epidermal Growth Factor Receptor Inhibitors: A Lead Optimization Case Study.

Belen Dominguez-Fernandez, C. Eigenbrot, Ivana Yen, 2015, Journal of medicinal chemistry.

An allosteric pan-TEAD inhibitor blocks oncogenic YAP/TAZ signaling and overcomes KRAS G12C inhibitor resistance

Thijs J. Hagenbeek, P. Beroza, Hoai An Le Thi, 2023, Nature Cancer.

Targeting the Hippo pathway in cancers via ubiquitination dependent TEAD degradation

Thijs J. Hagenbeek, Z. Modrušan, I. Wertz, 2023, bioRxiv.