K. Huang

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

Laura G. Dubois, Philip F. Hughes, J. Strachan, 2009, Journal of Medicinal Chemistry.

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.

Philip F. Hughes, J. Veal, S. Hall, 2012, Bioorganic & medicinal chemistry letters.

Discovery of benzamide tetrahydro-4H-carbazol-4-ones as novel small molecule inhibitors of Hsp90.

J. Veal, S. Hall, J. Rice, 2008, Bioorganic & medicinal chemistry letters.

Small molecule inhibitors of Hsp90 potently affect inflammatory disease pathways and exhibit activity in models of rheumatoid arthritis.

Laura G. Dubois, J. Veal, P. Fadden, 2008, Arthritis and rheumatism.

Process Development and Scale-Up of an Hsp90 Inhibitor

R. Garigipati, Laurence J. Lawless, Xuechuan Hong, 2012 .

Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.

Briana Foley, Laura G. Dubois, Philip F. Hughes, 2010, Chemistry & biology.

Derives de carbazole

J. Veal, G. Hanson, K. Huang, 2006 .

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.

Philip F. Hughes, J. Veal, S. Hall, 2012, Bioorganic & medicinal chemistry letters.