E. D. Smith

发表

Discovery of novel 2-aminobenzamide inhibitors of heat shock protein 90 as potent, selective and orally active antitumor agents.

Laura G. Dubois, Philip F. Hughes, J. Strachan, 2009, Journal of Medicinal Chemistry.

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.

Philip F. Hughes, J. Veal, S. Hall, 2012, Bioorganic & medicinal chemistry letters.

A six-step synthesis of (S)-5-ethenyl-3-(1-methyl-2-pyrrolidinyl)pyridine (SIB-1508Y) from (S)-nicotine

D. Comins, E. D. Smith, 2006 .

Regioselective C-2 and C-6 substitution of (S)-nicotine and nicotine derivatives.

D. Comins, E. D. Smith, Florence C. Fevrier, 2005, Organic letters.

Synthesis of C-4 substituted nicotine derivatives via an N-acylpyridinium salt of (S)-nicotine.

D. Comins, E. D. Smith, Florence C. Fevrier, 2005, Organic letters.

Synthesis of nicotine derivatives via reductive disilylation of (S)-nicotine.

D. Comins, E. D. Smith, Florence C. Fevrier, 2006, Organic letters.

A new synthesis of the ORL-1 antagonist 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one (J-113397) and activity in a calcium mobilization assay.

J. Deschamps, James B. Thomas, H. Navarro, 2008, Bioorganic & medicinal chemistry.

Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90.

Briana Foley, Laura G. Dubois, Philip F. Hughes, 2010, Chemistry & biology.

Design, synthesis and biological evaluation of renin inhibitors guided by simulated annealing of chemical potential simulations.

F. Guarnieri, J. Kulp, B. Grella, 2017, Bioorganic & medicinal chemistry.

Discovery of novel aminoquinazolin-7-yl 6,7-dihydro-indol-4-ones as potent, selective inhibitors of heat shock protein 90.

Philip F. Hughes, J. Veal, S. Hall, 2012, Bioorganic & medicinal chemistry letters.