D. Burns

发表

Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach.

R. Wynn, P. Scherle, K. Vaddi, 2022, Bioorganic & medicinal chemistry letters.

Discovery of a novel 2-spiro-proline steroid mimetic scaffold for the potent inhibition of 11β-HSD1.

R. Wynn, P. Scherle, Yanlong Li, 2022, Bioorganic & medicinal chemistry letters.

Sulfinimine-mediated asymmetric synthesis of 1,3-disubstituted tetrahydroisoquinolines: a stereoselective synthesis of cis- and trans-6,8-dimethoxy-1,3-dimethyl-1,2,3,4-tetrahydroisoquinoline.

Y. W. Andemichael, F. A. Davis, D. Burns, 2000, Organic letters.

Sulfinimines (Thiooximine S‐Oxides): Asymmetric Synthesis of Methyl (R)‐(+)‐β‐Phenylalanate from (S)‐(+)‐N‐(Benzylidene)‐p‐Toluenesulfinamide

F. A. Davis, G. V. Reddy, D. Fanelli, 2003 .

Asymmetric Synthesis of the Four Stereoisomers of 4-Hydroxypipecolic Acid

Tianan Fang, F. A. Davis, D. Burns, 2000 .

Asymmetric synthesis of alkaloids using polyfunctionalized chiral building blocks

Y. W. Andemichael, Tianan Fang, F. A. Davis, 2002 .

Asymmetric Synthesis of Conformationally Constrained trans-2,3-Piperidinedicarboxylic Acid Derivatives

B. Metcalf, W. Yao, Meizhong Xu, 2007 .

Discovery of novel selective HER-2 sheddase inhibitors through optimization of P1 moiety.

P. Scherle, Yanlong Li, M. Covington, 2009, Bioorganic & medicinal chemistry letters.

Identification of ADAM10 as a major source of HER2 ectodomain sheddase activity in HER2 overexpressing breast cancer cells

R. Wynn, P. Scherle, Phillip C. C. Liu, 2006, Cancer biology & therapy.

Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition.

R. Wynn, J. Fridman, P. Scherle, 2009, Bioorganic & Medicinal Chemistry Letters.

Phosgenated p-Nitrophenyl(polystyrene)ketoxime or Phoxime Resin. A New Resin for the Solid-Phase Synthesis of Ureas via Thermolytic Cleavage of Oxime-Carbamates†

Y. Hamuro, P. Soper, D. Burns, 1998 .

Conversion of an MMP-potent scaffold to an MMP-selective HER-2 sheddase inhibitor via scaffold hybridization and subtle P1' permutations.

J. Fridman, P. Scherle, K. Vaddi, 2008, Bioorganic & medicinal chemistry letters.

Chapter Ten - H4 Receptor Antagonists and Their Potential Therapeutic Applications

P. Scherle, W. Yao, N. Shin, 2014 .

Design and identification of selective HER-2 sheddase inhibitors via P1' manipulation and unconventional P2' perturbations to induce a molecular metamorphosis.

J. Fridman, P. Scherle, K. Vaddi, 2008, Bioorganic & medicinal chemistry letters.

Discovery of a potent, selective, and orally active human epidermal growth factor receptor-2 sheddase inhibitor for the treatment of cancer.

M. Bower, R. Wynn, J. Fridman, 2007, Journal of medicinal chemistry.

Discovery of 1'-(1-phenylcyclopropane-carbonyl)-3H-spiro[isobenzofuran-1,3'-pyrrolidin]-3-one as a novel steroid mimetic scaffold for the potent and tissue-specific inhibition of 11β-HSD1 using a scaffold-hopping approach.

R. Wynn, P. Scherle, K. Vaddi, 2022, Bioorganic & medicinal chemistry letters.