B. Mckeever

发表

Structure-based design and synthesis of 1,3-oxazinan-2-one inhibitors of 11β-hydroxysteroid dehydrogenase type 1.

Suresh B. Singh, P. Carroll, D. Claremon, 2011, Journal of medicinal chemistry.

Site-directed mutagenesis of glutathione S-transferase YaYa. Important roles of tyrosine 9 and aspartic acid 101 in catalysis.

A. Y. Lu, C. B. Pickett, S. Huskey, 1992, The Journal of biological chemistry.

FK-506-binding protein: three-dimensional structure of the complex with the antagonist L-685,818.

J. Springer, J. Hermes, G. Wiederrecht, 1994, The Journal of biological chemistry.

A Menin-MLL Inhibitor Induces Specific Chromatin Changes and Eradicates Disease in Models of MLL-Rearranged Leukemia.

K. Ross, S. Armstrong, Heather J. Lee, 2019, Cancer cell.

The discovery of tetrahydrofluorenones as a new class of estrogen receptor beta-subtype selective ligands.

H. Wilkinson, N. Sharma, M. Carlquist, 2006, Bioorganic & medicinal chemistry letters.

Both coactivator LXXLL motif-dependent and -independent interactions are required for peroxisome proliferator-activated receptor gamma (PPARgamma) function.

Y. Li, G. Zhou, D. Moller, 2000, The Journal of biological chemistry.

Fluorescence characterization of the low pH-induced change in diphtheria toxin conformation: effect of salt.

E. London, M. Blewitt, R. Sarma, 1984, Biochemical and biophysical research communications.

Preliminary crystallographic investigation of the protein toxin from corynebacterium diphtheriae.

R. Sarma, B. Mckeever, 1982, The Journal of biological chemistry.

Fluorescence Quenching by a Brominated Detergent: Application to Diphtheria Toxin Structure a

E. London, A. Chattopadhyay, M. Blewitt, 1984 .

Expression, purification and crystallization of human 5-lipoxygenase-activating protein with leukotriene-biosynthesis inhibitors.

Jilly F. Evans, A. Ferguson, Shihua Xu, 2007, Acta crystallographica. Section F, Structural biology and crystallization communications.

Design and Synthesis of α-Aryloxyphenylacetic Acid Derivatives: A Novel Class of PPARα/γ Dual Agonists with Potent Antihyperglycemic and Lipid Modulating Activity

Y. Chao, J. Berger, D. Moller, 2005 .

A new class of glycogen phosphorylase inhibitors.

R. Myers, K. Chapman, C. A. Willoughby, 2003, Bioorganic & medicinal chemistry letters.

Discovery of BI 135585, an in vivo efficacious oxazinanone-based 11β hydroxysteroid dehydrogenase type 1 inhibitor.

Suresh B. Singh, B. Hamilton, D. Lala, 2017, Bioorganic & medicinal chemistry.

New Renin Inhibitor VTP-27999 Alters Renin Immunoreactivity and Does Not Unfold Prorenin

B. McKeever, A. Danser, M. Schalekamp, 2013, Hypertension.

Structure of human neutrophil elastase in complex with a peptide chloromethyl ketone inhibitor at 1.84-A resolution.

E. Fluder, M. Navia, T. Lin, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Molecular structure of a stable N-methylimidazole-magnesium 2,4-dinitrophenoxide complex. A model for histidine and N.tau.-methylhistidine coordination in MgATPases and their uncouplers

F. Ramirez, J. Marecek, P. Narayanan, 1979 .

Synthesis and antiviral activity of a series of HIV-1 protease inhibitors with functionality tethered to the P1 or P1' phenyl substituents: X-ray crystal structure assisted design.

P. Darke, W. Schleif, J. Quintero, 1992, Journal of Medicinal Chemistry.

Identification of spirooxindole and dibenzoxazepine motifs as potent mineralocorticoid receptor antagonists.

Suresh B. Singh, B. McKeever, Andrew P. Marcus, 2016, Bioorganic & medicinal chemistry.

New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides.

M. Murcko, J. Springer, P. Mallorga, 1991, Journal of medicinal chemistry.

New Isomeric Classes of Topically Active Ocular Hypotensive Carbonic Anhydrase Inhibitors: 5‐Substituted Thieno(2,3‐b)thiophene‐2‐sulfonamides and 5‐Substituted Thieno(3,2‐b)thiophene‐2‐sulfonamides.

M. Murcko, J. Springer, P. Mallorga, 1991 .

Benzimidazolones: a new class of selective peroxisome proliferator-activated receptor γ (PPARγ) modulators.

Margaret S. Wu, J. Berger, Gaochao Zhou, 2011, Journal of medicinal chemistry.

Crystal and molecular structure of magnesium bromide-tetrahydrofuran complexes: bis(tetrahydrofuran)magnesium bromide, orthorhombic, and diaquotetrakis(tetrahydrofuran)magnesium bromide, triclinic

F. Ramirez, J. Marecek, R. Sarma, 1977 .

Three-dimensional structure of aspartyl protease from human immunodeficiency virus HIV-1

M. Navia, J. Springer, P. Darke, 1989, Nature.

INTERCONVERSION OF COMPOUNDS WITH PENTA-AND HEXACOORDINATE PHOSPHORUS. CRYSTAL AND MOLECULAR STRUCTURE OF THE TRIALKYLAMMONIUM HEXAOXYPHOSPHORIDE, [(PO6)(C6H5)2(C6H4)(CF3C[dbnd]CCF3)]−[(C2H5)3NH]+

F. Ramirez, J. Marecek, R. Sarma, 1979 .

Effects of fluorescamine modification on light-induced H+-movement in reconstituted purple membrane of halobacteria.

D. Shiuan, S. Tu, F. Ramirez, 1981, Biochemical and biophysical research communications.

Magnesium bromide-tetrahydrofuran complexes: bis(tetrahydrofuran)magnesium bromide, tris(tetrahydrofuran)magnesium bromide, tetrakis(tetrahydrofuran)magnesium bromide, and diaquotetrakis(tetrahydrofuran)magnesium bromide. A reagent for the preparation of anhydrous magnesium phosphodiester salts

F. Ramirez, J. Marecek, R. Sarma, 1977 .

Both Coactivator LXXLL Motif-dependent and -independent Interactions Are Required for Peroxisome Proliferator-activated Receptor γ (PPARγ) Function*

Bruce A. Johnson, D. Moller, Gaochao Zhou, 2000, The Journal of Biological Chemistry.

Amino acid substitution of arginine 80 in 17beta-hydroxysteroid dehydrogenase type 3 and its effect on NADPH cofactor binding and oxidation/reduction kinetics.

R. Sheridan, B. McKeever, W. Geissler, 2002, Biochimica et biophysica acta.

Crystal Structure of Inhibitor-Bound Human 5-Lipoxygenase-Activating Protein

Jilly F. Evans, Shihua Xu, A. Ferguson, 2007, Science.

The three-dimensional structure of human granzyme B compared to caspase-3, key mediators of cell death with cleavage specificity for aspartic acid in P1.

H G Bull, N. Thornberry, J. W. Becker, 2001, Chemistry & biology.

Structure-based design of β-site APP cleaving enzyme 1 (BACE1) inhibitors for the treatment of Alzheimer's disease.

Shankar Venkatraman, S. Venkatraman, Suresh B. Singh, 2013, Journal of medicinal chemistry.

Oxygen-exchange studies on the pathways for magnesium adenosine 5'-triphosphate hydrolysis by actomyosin.

K. Shukla, F. Ramirez, J. Marecek, 1983, Biochemistry.

Design and synthesis of alpha-aryloxyphenylacetic acid derivatives: a novel class of PPARalpha/gamma dual agonists with potent antihyperglycemic and lipid modulating activity.

Y. Chao, J. Berger, D. Moller, 2005, Journal of medicinal chemistry.

CRYSTAL AND MOLECULAR STRUCTURE OF PENTAPHENOXYPHOSPHORANE, (C6H5O)5P. THE CONFIGURATION OF ACYCLIC, MONOCYCLIC, AND SPIROBICYCLIC PENTAOXYPHOSPHORANES

F. Ramirez, J. Marecek, R. Sarma, 1976 .

Protein crystal growth results for shuttle flights STS-26 and STS-29

G. S. Nelson, L. DeLucas, D. Stammers, 1991 .

The Differential Interactions of Peroxisome Proliferator-Activated Receptor γ Ligands with Tyr473 Is a Physical Basis for Their Unique Biological Activities

J. Berger, D. Moller, J. W. Becker, 2008, Molecular Pharmacology.

Amine fluorescamine compounds inhibit oxidative phosphorylation in rat liver mitochondria.

S. Tu, F. Ramirez, J. Marecek, 1984, Archives of biochemistry and biophysics.

Crystal and molecular structure of phosphate esters. 9. Crystal and molecular structure of o-hydroxyphenyl-o-phenylene phosphate, (o-HOC6H4)(C6H4)PO4. Equilibrium between pentavalent and tetravalent phosphorus in solutions

F. Ramirez, J. Marecek, R. Sarma, 1978 .

CRYSTAL AND MOLECULAR STRUCTURE OF PHOSPHATE ESTERS. 9. CRYSTAL AND MOLECULAR R STRUCTURE OF O‐HYDROXYPHENYL‐O‐PHENYLENE PHOSPHATE, (O‐HOC6H4)(C6H4)PO4. EQUILIBRIUM BETWEEN PENTAVALENT AND TETRAVALENT PHOSPHORUS IN SOLUTIONS

F. Ramirez, J. Marecek, R. Sarma, 1978 .

Additions and Corrections - Magnesium Bromide-Tetrahydrofuran Complexes: MgBr2(C4H8O)2, MgBr2(C4H8O)3, MgBr2(C4H8O)4, and MgBr2(C4H8O)4(H2O)2. A Reagent for the Preparation of Anhydrous Magnesium Phosphodiester Salts.

F. Ramirez, J. Marecek, R. Sarma, 1978 .

Discovery of a Novel, Orally Efficacious Liver X Receptor (LXR) β Agonist.

K. Fan, R. Gregg, Zhijie Liu, 2016, Journal of medicinal chemistry.

A Role for the Aspartyl Protease from the Human Immunodeficiency Virus Type 1 (HIV‐1) in the Orchestration of Virus Assembly

M. Navia, B. Mckeever, 1990, Annals of the New York Academy of Sciences.

Structural Studies of Elastase-Inhibitor Complexes with ß-Lactams

M. Navia, J. Springer, B. Mckeever, 1990 .

Binding of a Reduced-Peptide Inhibitor and a Statine-Containing Inhibitor to the Protease from the Human Immunodeficiency Virus

J. Springer, P. Fitzgerald, J. VanMiddlesworth, 1991 .

Crystallization of the aspartylprotease from the human immunodeficiency virus, HIV-1.

M. Navia, J. Springer, P. Darke, 1989, The Journal of biological chemistry.

Preliminary crystallographic data for protein S, a development-specific protein of Myxococcus xanthus.

S. Inouye, M. Inouye, B. McKeever, 1980, The Journal of biological chemistry.

Crystallographic analysis of a complex between human immunodeficiency virus type 1 protease and acetyl-pepstatin at 2.0-A resolution.

R. Dixon, J. Springer, P. Darke, 1991, The Journal of biological chemistry.

Modeling aided design of potent glycogen phosphorylase inhibitors.

R. Myers, B. McKeever, K. Chapman, 2005, Journal of molecular graphics & modelling.

Discovery of VTP-27999, an Alkyl Amine Renin Inhibitor with Potential for Clinical Utility.

Wei Zhao, Joan Guo, David A Claremon, 2011, ACS medicinal chemistry letters.

Discovery and optimization of adamantyl carbamate inhibitors of 11β-HSD1.

R. Gregg, Suresh B. Singh, H. Nar, 2010, Bioorganic & medicinal chemistry letters.

Spirocyclic ureas: orally bioavailable 11 beta-HSD1 inhibitors identified by computer-aided drug design.

Suresh B. Singh, D. Claremon, C. Tice, 2010, Bioorganic & medicinal chemistry letters.

Regulation of Sphingomyelin Phosphodiesterase Acid-Like 3A Gene (SMPDL3A) by Liver X Receptors

D. Lala, P. Noto, Y. Bukhtiyarov, 2012, Molecular Pharmacology.

Brain penetrant liver X receptor (LXR) modulators based on a 2,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole core.

K. Fan, R. Gregg, Suresh B. Singh, 2016, Bioorganic & medicinal chemistry letters.

Crystallization of human neutrophil elastase.

M. Navia, T. Lin, J. Springer, 1987, Journal of Biological Chemistry.

Biphenyl/diphenyl ether renin inhibitors: filling the S1 pocket of renin via the S3 pocket.

R. Bentley, C. Doe, Suresh B. Singh, 2011, Bioorganic & medicinal chemistry letters.

Positions of His‐64 and a bound water in human carbonic anhydrase II upon binding three structurally related inhibitors

J. Springer, D. Christianson, R. Alexander, 1994, Protein science : a publication of the Protein Society.