Songwen Lin

发表

Switching the site-selectivity of C–H activation in aryl sulfonamides containing strongly coordinating N-heterocycles

Yi Dong, Xuepeng Zhang, Wen‐Lin Zou, 2019, Chemical science.

A novel orally active microtubule destabilizing agent S-40 targets the colchicine-binding site and shows potent antitumor activity.

T. Du, Qinghua Wang, Xiaoguang Chen, 2020, Cancer letters.

A novel PI3K inhibitor XH30 suppresses orthotopic glioblastoma and brain metastasis in mice models

Xiaoguang Chen, Jing Jin, M. Ji, 2021, Acta pharmaceutica Sinica. B.

Design and Optimization of Thienopyrimidine Derivatives as Potent and Selective PI3Kδ Inhibitors for the Treatment of B-Cell Malignancies.

Xiaoguang Chen, Jing Jin, Deyu Wu, 2022, Journal of medicinal chemistry.

Discovery of a novel photoswitchable PI3K inhibitor toward optically-controlled anticancer activity.

T. Du, Yan Y. Zhang, M. Ji, 2022, Bioorganic & medicinal chemistry.

Optimization of Benzamide Derivatives as Potent and Orally Active Tubulin Inhibitors Targeting the Colchicine Binding Site.

Tingting Du, Xiaoguang Chen, Yan Li, 2022, Journal of medicinal chemistry.

Synthesis and analgesic evaluation of a series of proline-typed spiro cyclic quaternary ammoniums

T. Cheng, Runtao Li, Qi Sun, 2014, Medicinal Chemistry Research.

Synthesis and structure-analgesic activity relationships of a novel series of monospirocyclopiperazinium salts (MSPZ).

Z. Ge, Run-tao Li, Xin Wang, 2011, Bioorganic & medicinal chemistry letters.

A novel PI3K/mTOR dual inhibitor XH002 exhibited robust antitumor activity in NSCLC

T. Du, Xiaoguang Chen, Nina Xue, 2018, Journal of drug targeting.

Discovery and Optimization of 2-Amino-4-methylquinazoline Derivatives as Highly Potent Phosphatidylinositol 3-Kinase Inhibitors for Cancer Treatment.

Xiaoguang Chen, Yan Li, L. Sheng, 2018, Journal of medicinal chemistry.

Discovery of new thienopyrimidine derivatives as potent and orally efficacious phosphoinositide 3-kinase inhibitors.

Xiaoguang Chen, Yan Li, L. Sheng, 2017, Bioorganic & medicinal chemistry.

Discovery of a Novel Series of Thienopyrimidine as Highly Potent and Selective PI3K Inhibitors.

P. Liu, Xiaobing Deng, C. Yi, 2015, ACS medicinal chemistry letters.

Design, synthesis and biological evaluation of quinazoline-phosphoramidate mustard conjugates as anticancer drugs.

Yingbo Li, Z. Ge, T. Cheng, 2017, European journal of medicinal chemistry.

Discovery of 4-Methyl Quinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis.

T. Du, Xiaoguang Chen, Yan Li, 2019, Journal of Medicinal Chemistry.

Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer

S. Zhang, Yue Chen, Xiaoguang Chen, 2018, Journal of drug targeting.

Discovery of new thieno[2,3-d]pyrimidine and thiazolo[5,4-d]pyrimidine derivatives as orally active phosphoinositide 3-kinase inhibitors.

Xiaoguang Chen, Yan Li, L. Sheng, 2020, Bioorganic & medicinal chemistry.

Design, Synthesis, and Biological Evaluation of 4-Methyl Quinazoline Derivatives as Anticancer Agents Simultaneously Targeting Phosphoinositide 3-Kinases and Histone Deacetylases.

Xiaoguang Chen, Yan Li, L. Sheng, 2019, Journal of medicinal chemistry.

Synthesis and structure-activity relationships of PI3K/mTOR dual inhibitors from a series of 2-amino-4-methylpyrido[2,3-d]pyrimidine derivatives.

P. Liu, C. Yi, Songwen Lin, 2014, Bioorganic & medicinal chemistry letters.

Identification of novel 7-amino-5-methyl-1,6-naphthyridin-2(1H)-one derivatives as potent PI3K/mTOR dual inhibitors.

P. Liu, Xue-Ping Zhong, C. Yi, 2014, Bioorganic & medicinal chemistry letters.

The PI3K Inhibitor XH30 Enhances Response to Temozolomide in Drug-Resistant Glioblastoma via the Noncanonical Hedgehog Signaling Pathway

Xiaoguang Chen, Nina Xue, Jing Jin, 2021, Frontiers in Pharmacology.

Identification of Novel Thiazolo[5,4-b]Pyridine Derivatives as Potent Phosphoinositide 3-Kinase Inhibitors

Yan Y. Zhang, Yi Dong, Kehui Zhang, 2020, Molecules.

Bt354 as a new STAT3 signaling pathway inhibitor against triple negative breast cancer

S. Zhang, Yue Chen, Xiaoguang Chen, 2018, Journal of drug targeting.

S-72, a Novel Orally Available Tubulin Inhibitor, Overcomes Paclitaxel Resistance via Inactivation of the STING Pathway in Breast Cancer

T. Du, Weida Wang, Xiaoguang Chen, 2023, Pharmaceuticals.

Design, Synthesis, and Biological Evaluation of a Novel Photocaged PI3K Inhibitor toward Precise Cancer Treatment.

Xiaoguang Chen, Yan Y. Zhang, M. Ji, 2021, Journal of medicinal chemistry.

Bioevaluation of a dual PI3K/HDAC inhibitor for the treatment of diffuse large B-cell lymphoma.

Deyu Wu, Lei Huang, Kehui Zhang, 2022, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Photocaged PI3K Inhibitor Capable of Real-Time Reporting of Drug Release.

Y. Li, T. Du, Xiaoguang Chen, 2023, ACS medicinal chemistry letters.

Ligand‐Free Cu‐Catalyzed O‐Arylation of Aliphatic Diols.

Qi Sun, Laichun Luo, Wen‐Lin Zou, 2015 .