J. Elliott

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Core Replacements in a Potent Series of VEGFR-2 Inhibitors and Their Impact on Potency, Solubility, and hERG.

K. Gunderson, N. Mainolfi, K. Anderson, 2016, ACS medicinal chemistry letters.

Concise Synthesis of Enantiomerically Pure Phenylalanine, Homophenylalanine, and Bishomophenylalanine Derivatives Using Organozinc Chemistry: NMR Studies of Amino Acid-Derived Organozinc Reagents.

C. Mowbray, R. Jackson, J. Elliott, 1999 .

N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists II.

G. Meneses‐Lorente, M. Rigby, K. Tsao, 2006, Bioorganic & medicinal chemistry letters.

Class III antiarrhythmic activity in vivo by selective blockade of the slowly activating cardiac delayed rectifier potassium current IKs by (R)-2-(2,4-trifluoromethyl)-N-[2-oxo-5-phenyl-1-(2,2,2-trifluoroethyl)- 2, 3-dihydro-1H-benzo[e][1,4]diazepin-3-yl]acetamide.

J J Baldwin, M. Sanguinetti, R. Freidinger, 1997, Journal of medicinal chemistry.

Studies on the synthesis of the core structures of the antitumor agents neocarzinostatin, kedarcidin, C-1027 and maduropeptin

T. Pitterna, P. Magnus, R. Carter, 1996 .

Regioselective synthesis of 4-(2-alkyl-5-methyl-2H-pyrazol-3-yl)-piperidines

M. Reader, A. Clipson, A. B. Jones, 2006 .

Non-oxidative methodology for the synthesis of vinblastine and vincristine models

M. Ladlow, P. Magnus, J. Elliott, 1989 .

Synthetic and mechanistic studies on the antitumor antibiotics esperamicin A1 and calicheamicin .gamma.1: synthesis of 2-ketobicyclo[7.3.1.]enediyne and 13-ketocyclo[7.3.1]enediyne cores mediated by .eta.2]dicobalt hexacarbonyl alkyne complexes. Cycloaromatization rate studies

William Bauta, R. Lewis, T. Pitterna, 1992 .

Neurokinin receptor antagonists

E. Seward, J. Elliott, 1997 .

Synthesis of vinylogous carbamates by rhodium(II)-catalyzed olefination of tertiary formamides with a silylated diazoester.

J. Elliott, M. Porter, Gurdeep S. Nandra, 2005, Organic letters.

Structure-based design and pre-clinical characterization of selective and orally bioavailable Factor XIa inhibitors: Demonstrating the power of an integrated S1 protease family approach.

V. Hornak, E. Altmann, A. D'arcy, 2020, Journal of medicinal chemistry.

2-Aryl indole NK1 receptor antagonists: optimisation of indole substitution.

K. Tsao, C. Swain, G. Hollingworth, 2001, Bioorganic & medicinal chemistry letters.

2-Aryl indole NK1 receptor antagonists: optimisation of the 2-aryl ring and the indole nitrogen substituent.

K. Tsao, C. Swain, G. Hollingworth, 2001, Bioorganic & medicinal chemistry letters.

Synthesis of Enantiomerically Pure β- and γ-Amino Acid Derivatives Using Functionalized Organozinc Reagents

R. Jackson, J. Elliott, C. S. Dexter, 1999 .

Reversed stereochemical control in the regioselective reduction of hindered diphenylphosphinoyl (Ph2PO−) ketones and enones

D. A. Hall, S. Warren, J. Elliott, 1989 .

Concise Synthesis of Enantiomerically Pure Phenylalanine, Homophenylalanine, and Bishomophenylalanine Derivatives Using Organozinc Chemistry: NMR Studies of Amino Acid-Derived Organozinc Reagents

C. Mowbray, R. Jackson, J. Elliott, 1998 .

Stereochemical control (E/Z and syn/anti) by the diphenylphosphinoyl group in the synthesis of allylic alcohols by allylic rearrangement and by 1,4-diastereoselective reduction of enones

A. Mcelroy, J. Clayden, S. J. Martin, 1993 .

Horner-Wittig reactions using dibenzophosphole oxides: Stereochemically controlled reduction of ketones

S. Warren, J. Elliott, 1986 .

Title Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration

J. Sivak, Fupeng Ma, P. Tarsa, 2018 .

Discovery of Oral VEGFR-2 Inhibitors with Prolonged Ocular Retention That Are Efficacious in Models of Wet Age-Related Macular Degeneration.

J. Sivak, B. Jaffee, Fupeng Ma, 2015, Journal of medicinal chemistry.

Organometallic chemistry can simplify the synthesis of important biologically active natural products

M. Slater, P. Carter, D. Becker, 1988, Philosophical Transactions of the Royal Society of London. Series A, Mathematical and Physical Sciences.

An effective prodrug strategy to selectively enhance ocular exposure of a cannabinoid receptor (CB1/2) agonist.

J. Sivak, M. Mclaughlin, B. Jaffee, 2013, Journal of medicinal chemistry.

Serine derived NK1 antagonists. 1: The effect of modifications to the serine substituents.

A. Macleod, G. Chicchi, M. Kurtz, 1998, Bioorganic & medicinal chemistry letters.

NK1 antagonists based on seven membered lactam scaffolds.

Alan Wheeldon, Maria Dominguez, U. Gerhard, 2006, Bioorganic & medicinal chemistry letters.

Novel lactam NK1 antagonists with anti-emetic activity.

K. Tsao, R. Kilburn, C. Swain, 2006, Bioorganic & medicinal chemistry letters.

4,4-Disubstituted cyclohexylamine NK(1) receptor antagonists II.

K. Tsao, C. Swain, G. Hollingworth, 2002, Bioorganic & medicinal chemistry letters.

2-Aryl indole NK(1) antagonists: optimisation of the amide substituent.

C. Swain, G. Chicchi, M. Kurtz, 2001, Bioorganic & medicinal chemistry letters.

A Convenient Method for the Preparation of Aryl Cyclopropyl Ethers from Phenols

C. Swain, G. Hollingworth, J. Kulagowski, 1999 .

NMR kinetic studies on the decomposition of beta-amidozinc reagents: optimization of palladium-catalyzed cross-coupling with acid chlorides.

R. Jackson, J. Elliott, C. S. Dexter, 2000, The Journal of organic chemistry.

Regiospecific synthesis of enones via α-(phenylthio)-ketones: 2,5-dimethyl-4-hexen-3-one, E-6-methyl-2-hepten-4-one, E-7-methyl-4-octen-3-one, and ar-turmerone

A. Mcelroy, S. Warren, J. Elliott, 1983 .

N',2-diphenylquinoline-4-carbohydrazide based NK3 receptor antagonists.

M. Rigby, K. Tsao, F. Murray, 2006, Bioorganic & medicinal chemistry letters.

The Discovery of N-(1-Methyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1H-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration.

J. Sivak, B. Jaffee, Fupeng Ma, 2018, Journal of medicinal chemistry.

4-Oxospiro[benzopyran-2,4'-piperidines] as class III antiarrhythmic agents. Pharmacological studies on 3,4-dihydro-1'-[2-(benzofurazan-5-yl)- ethyl]-6-methanesulfonamidospiro[(2H)-1-benzopyran-2,4'-piperidin]-4-on e (L-691,121).

B. T. Phillips, J. Baldwin, C. N. Habecker, 1992, Journal of medicinal chemistry.

Serine derived NK1 antagonists. 2: A pharmacophore model for arylsulfonamide binding.

H. Broughton, A. Macleod, I. Huscroft, 1998, Bioorganic & medicinal chemistry letters.

Aryl sulfones : A new class of γ-secretase inhibitors

Timothy Harrison, Euan R. Kay, U. Gerhard, 2005 .

Aryl sulfones: a new class of gamma-secretase inhibitors.

U. Gerhard, E. Kay, R. Ball, 2005, Bioorganic & medicinal chemistry letters.