Timothy J. McAfoos

发表

Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.

P. Mandal, Jason P. Burke, F. Mseeh, 2021, Journal of medicinal chemistry.

Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.

C. Rudin, Jason P. Burke, C. Bristow, 2020, Journal of medicinal chemistry.

Discovery of 6-[(3S,4S)-4-Amino-3-methyl-2-oxa-8-azaspiro[4.5]decan-8-yl]-3-(2,3-dichlorophenyl)-2-methyl-3,4-dihydropyrimidin-4-one (IACS-15414), a Potent and Orally Bioavailable SHP2 Inhibitor.

P. Mandal, Jason P. Burke, F. Mseeh, 2021, Journal of medicinal chemistry.

Biochemical characterization of NotB as an FAD-dependent oxidase in the biosynthesis of notoamide indole alkaloids.

Robert M. Williams, D. Sherman, Shengying Li, 2012, Journal of the American Chemical Society.

Genome-based characterization of two prenylation steps in the assembly of the stephacidin and notoamide anticancer agents in a marine-derived Aspergillus sp.

Kenneth A. Miller, Robert M. Williams, D. Sherman, 2010, Journal of the American Chemical Society.

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase

K. Houk, Robert M. Williams, J. N. Sanders, 2019, Nature Chemistry.

Allosteric SHP2 Inhibitor, IACS-13909, Overcomes EGFR-Dependent and EGFR-Independent Resistance Mechanisms toward Osimertinib

Justin K. Huang, P. Mandal, Jason P. Burke, 2020, Cancer Research.

Comparative analysis of the biosynthetic systems for fungal bicyclo[2.2.2]diazaoctane indole alkaloids: the (+)/(-)-notoamide, paraherquamide and malbrancheamide pathways.

Robert M. Williams, D. Sherman, F. Yu, 2012, MedChemComm.

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

M. Protopopova, R. DePinho, M. Konopleva, 2018, Nature Medicine.

Photochemical patterning of a self-assembled monolayer of 7-diazomethylcarbonyl-2,4,9-trithiaadmantane on gold films via Wolff rearrangement.

Jun Hu, C. Khemtong, Ian S Taschner, 2004, Langmuir : the ACS journal of surfaces and colloids.

Enantioselective inhibitory abilities of enantiomers of notoamides against RANKL-induced formation of multinuclear osteoclasts.

Robert M. Williams, Y. Sugimoto, S. Tsukamoto, 2017, Bioorganic & medicinal chemistry letters.

Synthesis and bioconversions of notoamide T: a biosynthetic precursor to stephacidin A and notoamide B.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2013, Organic letters.

STUDIES ON THE BIOSYNTHESIS OF THE STEPHACIDINS AND NOTOAMIDES. TOTAL SYNTHESIS OF NOTOAMIDE S.

Robert M. Williams, D. Sherman, S. Tsukamoto, 2010, Heterocycles.

Abstract 3277: IACS-9779, a development candidate that inhibits 2,3-dioxygenase (IDO) activity by blocking heme incorporation into IDO apoenzyme

F. Mseeh, T. Heffernan, Ningping Feng, 2019, Clinical Research (Excluding Clinical Trials).

Abstract PR01: IACS-010759 a novel inhibitor of oxidative phosphorylation advancing into first-in-human studies to exploit metabolic vulnerabilities

M. Protopopova, M. Konopleva, C. Bristow, 2017 .

Abstract A65: IACS-10759: A novel OXPHOS inhibitor that selectively kills tumors with metabolic vulnerabilities

Edward F. Chang, L. Chin, M. Protopopova, 2016 .

An inhibitor of oxidative phosphorylation exploits cancer vulnerability

M. Protopopova, R. DePinho, M. Konopleva, 2018, Nature Medicine.

Fungal indole alkaloid biogenesis through evolution of a bifunctional reductase/Diels–Alderase

K. Houk, J. N. Sanders, Janet L. Smith, 2018, Nature Chemistry.