John N. Breen

发表

Optimization of physicochemical properties and safety profile of novel bacterial topoisomerase type II inhibitors (NBTIs) with activity against Pseudomonas aeruginosa.

T. Dougherty, Liang Zhao, C. Eyermann, 2014, Bioorganic & medicinal chemistry.

Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II with reduced pK(a): antibacterial agents with an improved safety profile.

D. Ehmann, M. Cronin, A. A. Godfrey, 2012, Journal of medicinal chemistry.

Novel N-linked aminopiperidine inhibitors of bacterial topoisomerase type II: broad-spectrum antibacterial agents with reduced hERG activity.

C. Eyermann, D. Ehmann, M. Cronin, 2011, Journal of medicinal chemistry.

Characterization of seed-specific benzoyloxyglucosinolate mutations in Arabidopsis thaliana.

K. Gunderson, J. Gershenzon, D. Kliebenstein, 2007, The Plant journal : for cell and molecular biology.

Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors.

Christoph E. Dumelin, S. Kazmirski, A. Keefe, 2017, ACS medicinal chemistry letters.

4,5-Disubstituted 6-Aryloxy-1,3-dihydrobenzo[c][1,2]oxaboroles Are Broad-Spectrum Serine β-Lactamase Inhibitors.

C. Eyermann, A. Ferguson, R. Giacobbe, 2015, ACS infectious diseases.

In vivo validation of thymidylate kinase (TMK) with a rationally designed, selective antibacterial compound.

Diane Joseph-McCarthy, Sameer Kawatkar, D. Joseph-McCarthy, 2012, ACS chemical biology.

Antibacterial inhibitors of Gram-positive thymidylate kinase: structure-activity relationships and chiral preference of a new hydrophobic binding region.

T. Keating, Gabriel Martínez-Botella, John N Breen, 2014, Journal of medicinal chemistry.

Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK).

Diane Joseph-McCarthy, Jon Read, Sameer Kawatkar, 2012, Journal of medicinal chemistry.

Alkylidene Oxapenem β-Lactamase Inhibitors Revisited: Potent Broad Spectrum Activity but New Stability Challenges.

Matthew D. Miller, S. Tentarelli, Minli Zhang, 2014, ACS medicinal chemistry letters.