I. Gorshkova

发表

Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest.

D. Beiser, T. Vanden Hoek, V. Natarajan, 2013, Life sciences.

Ceramide synthase 4 and de novo production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells.

V. Natarajan, N. Therville, B. Portha, 2011, The Biochemical journal.

Novel Role for Non-muscle Myosin Light Chain Kinase (MLCK) in Hyperoxia-induced Recruitment of Cytoskeletal Proteins, NADPH Oxidase Activation, and Reactive Oxygen Species Generation in Lung Endothelium*

J. Garcia, S. Dudek, V. Natarajan, 2012, The Journal of Biological Chemistry.

Intracellular Generation of Sphingosine 1-Phosphate in Human Lung Endothelial Cells

J. Garcia, Yutong Zhao, V. Natarajan, 2007, Journal of Biological Chemistry.

FTY720 Inhibits Ceramide Synthases and Up-regulates Dihydrosphingosine 1-Phosphate Formation in Human Lung Endothelial Cells*

J. Garcia, S. Dudek, V. Natarajan, 2009, Journal of Biological Chemistry.

The sphingosine kinase 1/sphingosine-1-phosphate pathway in pulmonary arterial hypertension.

J. Garcia, R. Machado, J. Yuan, 2014, American journal of respiratory and critical care medicine.

Lysophosphatidic acid-induced transactivation of epidermal growth factor receptor regulates cyclo-oxygenase-2 expression and prostaglandin E(2) release via C/EBPbeta in human bronchial epithelial cells.

Yutong Zhao, V. Natarajan, J. Solway, 2008, The Biochemical journal.

Dynamin 2 and c-Abl Are Novel Regulators of Hyperoxia-mediated NADPH Oxidase Activation and Reactive Oxygen Species Production in Caveolin-enriched Microdomains of the Endothelium*

J. Garcia, V. Natarajan, P. Singleton, 2009, The Journal of Biological Chemistry.

Sphingosine Kinase 1 Deficiency Confers Protection against Hyperoxia-Induced Bronchopulmonary Dysplasia in a Murine Model

S. Reddy, Prasad Kanteti, V. Natarajan, 2013 .

Protein Kinase C-ϵ Regulates Sphingosine 1-Phosphate-mediated Migration of Human Lung Endothelial Cells through Activation of Phospholipase D2, Protein Kinase C-ζ, and Rac1*

J. Garcia, Yutong Zhao, V. Natarajan, 2008, Journal of Biological Chemistry.

Photolysis of caged sphingosine-1-phosphate induces barrier enhancement and intracellular activation of lung endothelial cell signaling pathways.

J. Garcia, V. Natarajan, Joe G. N. Garcia, 2011, American journal of physiology. Lung cellular and molecular physiology.

Protection of LPS-induced murine acute lung injury by sphingosine-1-phosphate lyase suppression.

J. Garcia, Yutong Zhao, V. Natarajan, 2011, American journal of respiratory cell and molecular biology.

The Roles of Sphingosine Kinase 1 and 2 in Regulating the Metabolome and Survival of Prostate Cancer Cells

V. Natarajan, S. Pyne, N. Pyne, 2013, Biomolecules.

Inhibition kinetics and regulation of sphingosine kinase 1 expression in prostate cancer cells: functional differences between sphingosine kinase 1a and 1b.

S. Pyne, N. Pyne, R. Bittman, 2012, The international journal of biochemistry & cell biology.

Changes in the metabolism of sphingolipids after subarachnoid hemorrhage

F. Testai, Haoliang Xu, D. Pelligrino, 2015, Journal of neuroscience research.

Characterization of sphingosine-1-phosphate lyase activity by electrospray ionization-liquid chromatography/tandem mass spectrometry quantitation of (2E)-hexadecenal.

G. Prestwich, V. Natarajan, Jonathan Goya, 2011, Analytical biochemistry.

Regulation of NADPH oxidase in vascular endothelium: the role of phospholipases, protein kinases, and cytoskeletal proteins.

V. Natarajan, Joe G. N. Garcia, P. Usatyuk, 2009, Antioxidants & redox signaling.

Changes in the Cerebrospinal Fluid Ceramide Profile After Subarachnoid Hemorrhage

P. Gorelick, S. Amin-Hanjani, F. Testai, 2012, Stroke.

Regulation of COX-2 expression and IL-6 release by particulate matter in airway epithelial cells.

J. Samet, A. Geyh, Yutong Zhao, 2009, American journal of respiratory cell and molecular biology.

De novo biosynthesis of dihydrosphingosine-1-phosphate by sphingosine kinase 1 in mammalian cells.

Yutong Zhao, V. Natarajan, W. Hubbard, 2006, Cellular signalling.

Gabor Tigyi, Y. Fujiwara, V. Natarajan, 2022 .

Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: role of S1P signalling and autophagy

I. Noth, Wei Zhang, S. Reddy, 2015, Thorax.

Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells.

V. Natarajan, J. Lambeth, V. Thannickal, 2009, Antioxidants & redox signaling.

Multiple sphingolipid abnormalities following cerebral microendothelial hypoxia

F. Testai, V. Natarajan, G. Dawson, 2014, Journal of neurochemistry.

Docosatetraenoyl LPA is elevated in exhaled breath condensate in idiopathic pulmonary fibrosis

L. Brenner, A. Tager, B. Shea, 2014, BMC Pulmonary Medicine.

Lipid Phosphate Phosphatase-1 Regulates Lysophosphatidate-induced Fibroblast Migration by Controlling Phospholipase D2-dependent Phosphatidate Generation*

V. Natarajan, G. Tigyi, D. Brindley, 2006, Journal of Biological Chemistry.

Akt activates NOS3 and separately restores barrier integrity in H2O2-stressed human cardiac microvascular endothelium.

V. Natarajan, P. Long, Z. Shao, 2008, American journal of physiology. Heart and circulatory physiology.

Targeting sphingosine kinase 1 attenuates bleomycin‐induced pulmonary fibrosis

I. Noth, Wei Zhang, S. Reddy, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Phospholipase D-mediated Activation of IQGAP1 through Rac1 Regulates Hyperoxia-induced p47phox Translocation and Reactive Oxygen Species Generation in Lung Endothelial Cells*

Yutong Zhao, V. Natarajan, S. Kalari, 2009, Journal of Biological Chemistry.

Quantitative analysis of sphingoid base-1-phosphates as bisacetylated derivatives by liquid chromatography-tandem mass spectrometry.

V. Natarajan, W. Hubbard, Joe G N Garcia, 2005, Analytical biochemistry.

Role of palmitate-induced sphingoid base-1-phosphate biosynthesis in INS-1 β-cell survival.

V. Natarajan, Jonathan Goya, N. Kassis, 2013, Biochimica et biophysica acta.

Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation.

G. Prestwich, V. Aidinis, J. Chun, 2013, American journal of respiratory and critical care medicine.

Intracellular S1P Generation Is Essential for S1P-Induced Motility of Human Lung Endothelial Cells: Role of Sphingosine Kinase 1 and S1P Lyase

J. Garcia, Yutong Zhao, V. Natarajan, 2011, PloS one.

Oxidized phospholipids reduce vascular leak and inflammation in rat model of acute lung injury.

J. Garcia, V. Natarajan, V. Bochkov, 2006, American journal of respiratory and critical care medicine.

Inhibition of serine palmitoyltransferase delays the onset of radiation-induced pulmonary fibrosis through the negative regulation of sphingosine kinase-1 expression[S]

R. Weichselbaum, T. Zhou, V. Natarajan, 2012, Journal of Lipid Research.

Dynamin 2 and c-Abl Are Novel Regulators of Hyperoxia-Mediated NADPH Oxidase Activation and ROS Production in Caveolin-Enriched Microdomains of the Endothelium.

V. Natarajan, P. Singleton, Joe G. N. Garcia, 2009, ATS 2009.

Sphingosine kinase 1 deficiency confers protection against hyperoxia-induced bronchopulmonary dysplasia in a murine model: role of S1P signaling and Nox proteins.

S. Reddy, Prasad Kanteti, V. Natarajan, 2013, The American journal of pathology.

-Supplemental Data – Sphingosine-1-phosphate lyase is an endogenous suppressor of pulmonary fibrosis: Role of S1P signaling and autophagy

I. Noth, Wei Zhang, S. Reddy, 2015 .

The roles of sphingosine kinases 1 and 2 in regulating the Warburg effect in prostate cancer cells.

S. Pyne, N. Pyne, R. Bittman, 2013, Cellular signalling.

Protein Kinase C- Regulates Sphingosine 1-Phosphate-mediated Migration of Human Lung Endothelial Cells through Activation of Phospholipase D2,

Yutong Zhao, V. Natarajan, N. Pyne, 2008 .

Targeting sphingosine kinase 1 attenuates bleomycin‐induced pulmonary fibrosis

I. Noth, Wei Zhang, S. Reddy, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Inhibition of sphingosine-1-phosphate lyase rescues sphingosine kinase-1-knockout phenotype following murine cardiac arrest.

D. Beiser, V. Natarajan, Jonathan Goya, 2013, Life sciences.

Role of Nox4 and Nox2 in hyperoxia-induced reactive oxygen species generation and migration of human lung endothelial cells.

V. Natarajan, J. Lambeth, V. Thannickal, 2009, Antioxidants & redox signaling.