S. Fidanze

发表

Preclinical Characterization of BET Family Bromodomain Inhibitor ABBV-075 Suggests Combination Therapeutic Strategies.

L. Lam, Xin Lu, S. Rosenberg, 2017, Cancer research.

Discovery and optimization of anthranilic acid sulfonamides as inhibitors of methionine aminopeptidase-2: a structural basis for the reduction of albumin binding.

Scott A. Erickson, S. Davidsen, A. Petros, 2006, Journal of medicinal chemistry.

Selective inhibition of the BD2 bromodomain of BET proteins in prostate cancer

L. Lam, Chaohong Sun, S. Rosenberg, 2020, Nature.

Discovery of N-(4-(2,4-Difluorophenoxy)-3-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)phenyl)ethanesulfonamide (ABBV-075/Mivebresib), a Potent and Orally Available Bromodomain and Extraterminal Domain (BET) Family Bromodomain Inhibitor.

Chaohong Sun, L. Hasvold, Chang H. Park, 2017, Journal of Medicinal Chemistry.

Discovery of N-ethyl-4-[2-(4-fluoro-2,6-dimethyl-phenoxy)-5-(1-hydroxy-1-methyl-ethyl)phenyl]-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridine-2-carboxamide (ABBV-744), a BET bromodomain inhibitor with selectivity for the second bromodomain.

K. Longenecker, P. Kovar, L. Hasvold, 2020, Journal of medicinal chemistry.

Correction to Structure-Guided Design of a Series of MCL-1 Inhibitors with High Affinity and Selectivity.

Scott A. Erickson, C. Tse, A. Petros, 2015, Journal of medicinal chemistry.

cis-1-Aminoindan-2-ol in Asymmetric Syntheses

Arun K. Ghosh, C. Senanayake, S. Fidanze, 1998, Synthesis.

Development of sulfonamide compounds as potent methionine aminopeptidase type II inhibitors with antiproliferative properties.

Scott A. Erickson, K. Comess, A. Vasudevan, 2006, Bioorganic & medicinal chemistry letters.

Asymmetric synthesis of (-)-tetrahydrolipstatin: an anti-aldol-based strategy.

Arun K. Ghosh, A. Ghosh, S. Fidanze, 2000, Organic letters.

7.06 – Alkylating and Platinum Antitumor Compounds

R. Hubbard, S. Fidanze, 2007 .

Total Synthesis of Mycolactones A and B.

Y. Kishi, F. Song, S. Fidanze, 2007, Tetrahedron.

4‐tert‐Butoxycarbonyl‐5,6‐diphenyl‐2,3,5,6‐tetrahydro‐4H‐oxazin‐2‐one

P. Sinclair, S. Fidanze, 2008 .

ESTER DERIVED TITANIUM ENOLATE ALDOL REACTION: HIGHLY DIASTEREOSELECTIVE SYNTHESIS OF SYN- AND ANTI-ALDOLS.

Arun K. Ghosh, M. Onishi, K. A. Hussain, 1997, Tetrahedron letters.

2,3‐Dihydro‐2‐[[(2S)‐1‐methyl‐2‐pyrrolidinyl]methyl]‐1H‐isoindole

S. Fidanze, 2004 .

Transition-State Mimetics for HIV Protease Inhibitors: Stereocontrolled Synthesis of Hydroxyethylene and Hydroxyethylamine Isosteres by Ester-Derived Titanium Enolate Syn and Anti-Aldol Reactions.

Arun K. Ghosh, S. Fidanze, 1998, The Journal of organic chemistry.

Asymmetric Aldol Route to Hydroxyethylamine Isostere: Stereoselective Synthesis of the Core Unit of Saquinavir.

Arun K. Ghosh, K. A. Hussain, S. Fidanze, 1997, The Journal of organic chemistry.

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.

A. Petros, Chaohong Sun, P. Kovar, 2017, Journal of medicinal chemistry.

Structure-guided design of a series of MCL-1 inhibitors with high affinity and selectivity.

Scott A. Erickson, C. Tse, A. Petros, 2015, Journal of medicinal chemistry.

Imidazo[2,1-b]thiazoles: multitargeted inhibitors of both the insulin-like growth factor receptor and members of the epidermal growth factor family of receptor tyrosine kinases.

Scott A. Erickson, S. Davidsen, K. Swinger, 2010, Bioorganic & medicinal chemistry letters.

Stereochemistry of the core structure of the mycolactones.

P. Small, A B Benowitz, S Fidanze, 2001, Journal of the American Chemical Society.

Total synthesis of the mycolactones.

Y. Kishi, F. Song, S. Fidanze, 2002, Organic letters.

Complete structure of the mycolactones.

P. Small, Y. Kishi, F. Song, 2001, Journal of the American Chemical Society.

Insulin-like Growth Factor-1 Receptor and ErbB Kinase Inhibitor Combinations Block Proliferation and Induce Apoptosis through Cyclin D1 Reduction and Bax Activation*

S. Davidsen, J. Wilsbacher, Gary T. Wang, 2008, Journal of Biological Chemistry.

Development of multitargeted inhibitors of both the insulin-like growth factor receptor (IGF-IR) and members of the epidermal growth factor family of receptor tyrosine kinases.

Scott A. Erickson, S. Davidsen, Eric F. Johnson, 2009, Bioorganic & medicinal chemistry letters.

Fragment-Based, Structure-Enabled Discovery of Novel Pyridones and Pyridone Macrocycles as Potent Bromodomain and Extra-Terminal Domain (BET) Family Bromodomain Inhibitors.

A. Petros, P. Kovar, Chang H. Park, 2017, Journal of medicinal chemistry.

Discovery and optimization of novel constrained pyrrolopyridone BET family inhibitors.

Ana L. Aguirre, A. Bogdan, Justin D Dietrich, 2018, Bioorganic & medicinal chemistry letters.

Methylpyrrole inhibitors of BET bromodomains.

A. Petros, N. Soni, P. Kovar, 2017, Bioorganic & medicinal chemistry letters.

Chang H. Park, D. Albert, Emily J. Faivre, 2017, Journal of medicinal chemistry.