K. Temple

发表

Contributions of Protease-Activated Receptors PAR1 and PAR4 to Thrombin-Induced GPIIbIIIa Activation in Human Platelets

Anna L. Blobaum, H. Hamm, C. Lindsley, 2017, Molecular Pharmacology.

Exploration of GGTase-I substrate requirements. Part 1: Synthesis and biochemical evaluation of novel aryl-modified geranylgeranyl diphosphate analogs.

R. Gibbs, C. Fierke, E. Wright, 2016, Bioorganic & medicinal chemistry letters.

Development of a Series of (1-Benzyl-3-(6-methoxypyrimidin-3-yl)-5-(trifluoromethoxy)-1H-indol-2-yl)methanols as Selective Protease Activated Receptor 4 (PAR4) Antagonists with in Vivo Utility and Activity Against γ-Thrombin.

Anna L. Blobaum, H. Hamm, C. Lindsley, 2016, Journal of medicinal chemistry.

Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis.

Marcin J. Skwark, A. Pozzi, J. Meiler, 2017, Matrix biology : journal of the International Society for Matrix Biology.

Protease-activated receptor 4 activity promotes platelet granule release and platelet-leukocyte interactions

Laura D. Healy, H. Hamm, O. McCarty, 2019, Platelets.

Identification of the minimum PAR4 inhibitor pharmacophore and optimization of a series of 2-methoxy-6-arylimidazo[2,1-b][1,3,4]thiadiazoles.

Anna L. Blobaum, H. Hamm, C. Lindsley, 2016, Bioorganic & medicinal chemistry letters.

Synthesis of Novel Isoprenoid Diphosphate Analogs as Chemical Tools to Investigate Protein Geranylgeranylation

K. Temple, K. J. Temple, Kayla J. Temple, 2013 .

Synthesis of Non-natural, Frame-Shifted Isoprenoid Diphosphate Analogues.

R. Gibbs, C. Fierke, E. Wright, 2016, Organic letters.

Exploration of GGTase-I substrate requirements. Part 2: Synthesis and biochemical analysis of novel saturated geranylgeranyl diphosphate analogs.

R. Gibbs, C. Fierke, E. Wright, 2016, Bioorganic & medicinal chemistry letters.

M1 Muscarinic Receptors Modulate Fear-Related Inputs to the Prefrontal Cortex: Implications for Novel Treatments of Posttraumatic Stress Disorder

S. P. Moran, C. Lindsley, D. Engers, 2019, Biological Psychiatry.

Discovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype.

Julie L. Engers, C. Lindsley, C. Niswender, 2019, Bioorganic & medicinal chemistry letters.

Discovery of structurally distinct tricyclic M4 positive allosteric modulator (PAM) chemotypes.

Julie L. Engers, C. Lindsley, C. Niswender, 2019, Bioorganic & medicinal chemistry letters.

Discovery of a novel 3,4-dimethylcinnoline carboxamide M4 positive allosteric modulator (PAM) chemotype via scaffold hopping.

Alison R. Gregro, Julie L. Engers, C. Lindsley, 2019, Bioorganic & medicinal chemistry letters.