R. Lachance

发表

Pharmacological Intervention at Disparate Sites in the Coagulation Cascade: Comparison of Anti-thrombotic Efficacy vs. Bleeding Propensity in a Rat Model of Acute Arterial Thrombosis

T. Girard, J. A. Szalony, N. Nicholson, 2002, Journal of Thrombosis and Thrombolysis.

Administration of a small molecule tissue factor/factor VIIa inhibitor in a non-human primate thrombosis model of venous thrombosis: effects on thrombus formation and bleeding time.

M. S. South, J. J. Parlow, A. Salyers, 2003, Thrombosis research.

Polymer-assisted solution-phase (PASP) parallel synthesis of an alpha-ketothiazole library as tissue factor VIIa inhibitors.

R. Kurumbail, W. Stallings, A. Stevens, 2003, Bioorganic & medicinal chemistry letters.

Pharmacological Interruption of Acute Thrombus Formation with Minimal Hemorrhagic Complications by a Small Molecule Tissue Factor/Factor VIIa Inhibitor: Comparison to Factor Xa and Thrombin Inhibition in a Nonhuman Primate Thrombosis Model

M. S. South, J. J. Parlow, A. Salyers, 2003, Journal of Pharmacology and Experimental Therapeutics.

Piperazinyl-glutamate-pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation.

S. Rapp, M. D. Ennis, T. Girard, 2009, Bioorganic & medicinal chemistry letters.

Piperazinyl glutamate pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation.

S. Rapp, M. D. Ennis, P. Harris, 2010, Journal of medicinal chemistry.

Part II: piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation.

S. Rapp, M. D. Ennis, P. Harris, 2010, Bioorganic & medicinal chemistry letters.

Design, parallel synthesis, and crystal structures of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.

R. Kurumbail, W. Stallings, A. Stevens, 2003, Journal of medicinal chemistry.

Structure-based drug design of pyrazinone antithrombotics as selective inhibitors of the tissue factor VIIa complex.

R. Kurumbail, W. Stallings, A. Stevens, 2003, Bioorganic & medicinal chemistry letters.

Inhibitory activity of unsaturated fatty acids and anacardic acids toward soluble tissue factor-factor VIIa complex.

T. Kasten, R. C. Durley, T. Girard, 1998, Journal of natural products.

Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation.

S. Rapp, M. D. Ennis, T. Girard, 2009, Bioorganic & medicinal chemistry letters.

Polymer-assisted solution-phase library synthesis and crystal structure of alpha-ketothiazoles as tissue factor VIIa inhibitors.

R. Kurumbail, W. Stallings, A. Stevens, 2003, Journal of medicinal chemistry.

Thienopyrimidine-based P2Y12 platelet aggregation inhibitors.

B. Schweitzer, M. D. Ennis, G. Yalamanchili, 2009, Bioorganic & medicinal chemistry letters.