A. Hasegawa

发表

In vivo genotoxicity evaluation of dimethylarsinic acid in MutaMouse.

A. Kohara, Takayoshi Suzuki, T. Sofuni, 2002, Mutation research.

DNA damage induced in cultured human alveolar (L-132) cells by exposure to dimethylarsinic acid.

S. Okada, K. Yamanaka, Koichi Kato, 1994, Environmental health perspectives.

The role of orally administered dimethylarsinic acid, a main metabolite of inorganic arsenics, in the promotion and progression of UVB-induced skin tumorigenesis in hairless mice.

S. Okada, K. Ikuma, K. Yamanaka, 2000, Cancer letters.

Cellular response to oxidative damage in lung induced by the administration of dimethylarsinic acid, a major metabolite of inorganic arsenics, in mice.

S. Okada, K. Yamanaka, A. Hasegawa, 1991, Toxicology and applied pharmacology.

Dimethylated arsenics induce DNA strand breaks in lung via the production of active oxygen in mice.

S. Okada, K. Yamanaka, A. Hasegawa, 1989, Biochemical and biophysical research communications.

Exposure to dimethylarsinic acid, a main metabolite of inorganic arsenics, strongly promotes tumorigenesis initiated by 4-nitroquinoline 1-oxide in the lungs of mice.

S. Okada, K. Yamanaka, H. Hayashi, 1996, Carcinogenesis.

Involvement of preferential formation of apurinic/apyrimidinic sites in dimethylarsenic-induced DNA strand breaks and DNA-protein crosslinks in cultured alveolar epithelial cells.

S. Okada, K. Yamanaka, K. Kato, 1995, Biochemical and biophysical research communications.

Induction of DNA damage by dimethylarsine, a metabolite of inorganic arsenics, is for the major part likely due to its peroxyl radical.

S. Okada, M. Hoshino, K. Yamanaka, 1990, Biochemical and biophysical research communications.

72-kDa stress protein (hsp72) induced by administration of dimethylarsinic acid to mice accumulates in alveolar flat cells of lung, a target organ for arsenic carcinogenesis.

S. Okada, K. Yamanaka, M. Nakano, 2000, Biological & pharmaceutical bulletin.

Dimethylarsinic acid exposure causes accumulation of Hsp72 in cell nuclei and suppresses apoptosis in human alveolar cultured (L-132) cells.

S. Okada, K. Yamanaka, K. Kato, 1999, Biological & pharmaceutical bulletin.

Cell-nuclear accumulation of 72-kDa stress protein induced by dimethylated arsenics.

N. Oku, S. Okada, K. Yamanaka, 1997, Biological & pharmaceutical bulletin.

On the Chemical Form of Mercury in Kidney After Intraveneous Injection of Phenylmercuric Acetate.

Y. Kido, A. Hasegawa, G. Urakubo, 1967 .

DNA strand breaks in mammalian tissues induced by methylarsenics

S. Okada, K. Yamanaka, A. Hasegawa, 1989, Biological Trace Element Research.

Oral exposure of dimethylarsinic acid, a main metabolite of inorganic arsenics, in mice leads to an increase in 8-Oxo-2'-deoxyguanosine level, specifically in the target organs for arsenic carcinogenesis.

S. Okada, Y. An, F. Takabayashi, 2001, Biochemical and biophysical research communications.

Age-associated changes of oxidative modification and turnover of proteins

S. Goto, A. Nakamura, R. Takahashi, 1995 .

Oral administration of dimethylarsinic acid, a main metabolite of inorganic arsenic, in mice promotes skin tumorigenesis initiated by dimethylbenz(a)anthracene with or without ultraviolet B as a promoter.

S. Okada, K. Yamanaka, M. Nakano, 2001, Biological & pharmaceutical bulletin.

Mutagenicity of dimethylated metabolites of inorganic arsenics.

S. Okada, K. Yamanaka, A. Hasegawa, 1989, Chemical & pharmaceutical bulletin.

Crosslink formation between DNA and nuclear proteins by in vivo and in vitro exposure of cells to dimethylarsinic acid.

S. Okada, K. Yamanaka, M. Tezuka, 1993, Biochemical and biophysical research communications.

Oxidative DNA damage following exposure to dimethylarsinous iodide: the formation of cis-thymine glycol.

S. Okada, M. Hoshino, K. Yamanaka, 2003, Toxicology letters.

Metabolic methylation is a possible genotoxicity-enhancing process of inorganic arsenics.

N. Oku, S. Okada, K. Yamanaka, 1997, Mutation research.

Active arsenic species produced by GSH-dependent reduction of dimethylarsinic acid cause micronuclei formation in peripheral reticulocytes of mice.

S. Okada, K. Yamanaka, Koichi Kato, 2003, Mutation research.

Preferential increase of heterochromatin in venular endothelium of lung in mice after administration of dimethylarsinic acid, a major metabolite of inorganic arsenics.

S. Okada, K. Yamanaka, M. Nakano, 1992, Carcinogenesis.

Mouse brain opioid receptor identification by direct ultraviolet photoaffinity labeling.

K. Nagamatsu, A. Hasegawa, Y. Tagawa, 1993, Biochemical Pharmacology.

DNA single-strand breaks in L-132 cells resulting from inhibition of repair polymerization shortly after exposure to dimethylarsinic acid.

N. Oku, S. Okada, K. Yamanaka, 1997, Biological & pharmaceutical bulletin.

Physiological significance of calcium excretion into the bile of rats.

T. Yamamoto, M. Yamaguchi, A. Hasegawa, 1979, Chemical & pharmaceutical bulletin.

[Mechanism of anemia in selenium poisoning rats. (II). Behavior of vitamin B12 and mechanism of anemia by selenium dosing (author's transl)].

Y. Suketa, T. Yamamoto, A. Hasegawa, 1977, Nihon eiseigaku zasshi. Japanese journal of hygiene.

Metabolism and Toxicity of Acid Phosphate Esters, Metabolites of Organophosphorous Insecticides, in Rat.

Y. Ohno, A. Takanaka, K. Nagamatsu, 1993 .

Metabolic fate of zinc ethylphenyldithiocarbamate in rats.

K. Yamanaka, A. Hasegawa, R. Sawamura, 1990, Nihon eiseigaku zasshi. Japanese journal of hygiene.

Effect of potassium iodide concentration on measurement of combined available chlorine.

E. Sakurai, M. Tachikawa, A. Hasegawa, 1988 .

Studies on the Fate of Poisonous Metals in Experimental Animal (VI)

A. Hasegawa, S. Nakaura, G. Urakubo, 1975 .