Giulia I. Corsi

发表

CRISPR/Cas9 gRNA activity depends on free energy changes and on the target PAM context

J. Gorodkin, Kunli Qu, Xiaoguang Pan, 2022, Nature Communications.

Massively targeted evaluation of therapeutic CRISPR off-targets in cells

George M. Church, Ping Liu, Huanming Yang, 2022, Nature Communications.

Astrocytic Reactivity Triggered by defective Mitophagy Activates NF-kB Signaling and Causes Neurotoxicity in Frontotemporal Dementia Type 3

Nadezhda T. Doncheva, J. Gorodkin, S. Cirera, 2021 .

The transcriptomic landscape of neurons carrying PSEN1 mutations reveals changes in extracellular matrix components and non-coding gene expression

Nadezhda T. Doncheva, J. Gorodkin, N. Doncheva, 2022, Neurobiology of Disease.

Evolutionary epidemiology of a zoonosis

N. Segata, F. Asnicar, A. Jex, 2021 .

Astrocytic reactivity triggered by defective autophagy and metabolic failure causes neurotoxicity in frontotemporal dementia type 3

Nadezhda T. Doncheva, J. Gorodkin, S. Cirera, 2021, Stem cell reports.

CRISPRroots: on- and off-target assessment of RNA-seq data in CRISPR–Cas9 edited cells

J. Gorodkin, S. Seemann, Veerendra P. Gadekar, 2021, Nucleic acids research.

Novel circRNA discovery in sheep shows evidence of high backsplice junction conservation

J. Gorodkin, B. Jugo, Endika Varela-Martínez, 2021, Scientific reports.

Golgi fragmentation - One of the earliest organelle phenotypes in Alzheimer’s disease neurons

Nadezhda T. Doncheva, J. Gorodkin, S. Cirera, 2022, bioRxiv.

Enhancing CRISPR-Cas9 gRNA efficiency prediction by data integration and deep learning

G. Church, Huanming Yang, J. Gorodkin, 2021, Nature Communications.