P. DeAngelis

发表

Acceptor Specificity of the Pasteurella Hyaluronan and Chondroitin Synthases and Production of Chimeric Glycosaminoglycans*

R. Linhardt, F. Avci, B. S. Tracy, 2007, Journal of Biological Chemistry.

Nanoparticle Surface Engineering with Heparosan Polysaccharide Reduces Serum Protein Adsorption and Enhances Cellular Uptake.

S. Wilhelm, Yushan Zhang, Wen Yang, 2022, Nano letters.

Molecular Directionality of Polysaccharide Polymerization by thePasteurella multocida Hyaluronan Synthase*

P. DeAngelis, 1999, The Journal of Biological Chemistry.

Dissection of the two transferase activities of the Pasteurella multocida hyaluronan synthase: two active sites exist in one polypeptide.

W. Jing, P. DeAngelis, 2000, Glycobiology.

Chemoenzymatic Synthesis of 4-Fluoro-N-Acetylhexosamine Uridine Diphosphate Donors: Chain Terminators in Glycosaminoglycan Synthesis.

R. Linhardt, Jenna K. Rimel, Victor L. Schultz, 2017, The Journal of organic chemistry.

Isolation of a Streptococcus pyogenes gene locus that directs hyaluronan biosynthesis in acapsular mutants and in heterologous bacteria.

P. Weigel, J. Papaconstantinou, P. DeAngelis, 1993, The Journal of biological chemistry.

Heparosan, a promising ‘naturally good’ polymeric conjugating vehicle for delivery of injectable therapeutics

P. DeAngelis, 2015, Expert opinion on drug delivery.

Heparan Sulfate Domains Required for Fibroblast Growth Factor 1 and 2 Signaling through Fibroblast Growth Factor Receptor 1c*

R. Linhardt, Fuming Zhang, Yongmei Xu, 2016, The Journal of Biological Chemistry.

Synthesis of 4-Azido-N-acetylhexosamine Uridine Diphosphate Donors: Clickable Glycosaminoglycans.

S. Kim, R. Linhardt, Xiaorui Han, 2017, The Journal of organic chemistry.

Chemoenzymatic Synthesis with Distinct Pasteurella Heparosan Synthases

M. Rejžek, R. Field, D. E. Green, 2007, Journal of Biological Chemistry.

Synchronized Chemoenzymatic Synthesis of Monodisperse Hyaluronan Polymers*

W. Jing, P. DeAngelis, 2004, Journal of Biological Chemistry.

Functional Characterization of PmHS1, a Pasteurella multocida Heparosan Synthase*

C. White, T. A. Kane, P. DeAngelis, 2006, Journal of Biological Chemistry.

Methods for the Pasteurella glycosaminoglycan synthases: enzymes that polymerize hyaluronan, chondroitin, or heparosan chains.

P. DeAngelis, 2013, Methods in molecular biology.

Critical Elements of Oligosaccharide Acceptor Substrates for the Pasteurella multocida Hyaluronan Synthase*

J. Kamerling, K. Halkes, P. DeAngelis, 2006, Journal of Biological Chemistry.

Identification and Molecular Cloning of a Chondroitin Synthase from Pasteurella multocida Type F*

P. DeAngelis, A. J. Padgett-McCue, Amy J. Padgett-McCue, 2000, The Journal of Biological Chemistry.

Chlorella virus PBCV-1 encodes functional glutamine: fructose-6-phosphate amidotransferase and UDP-glucose dehydrogenase enzymes.

J. V. Van Etten, D. Burbank, D. Landstein, 1998, Virology.

Rapid detection of hyaluronic acid capsules on group A streptococci by buoyant density centrifugation.

P. Weigel, P. DeAngelis, 1994, Diagnostic microbiology and infectious disease.

Immunochemical confirmation of the primary structure of streptococcal hyaluronan synthase and synthesis of high molecular weight product by the recombinant enzyme.

P. Weigel, P. DeAngelis, 1994, Biochemistry.

MINI REVIEW Microbial glycosaminoglycan glycosyltransferases

P. DeAngelis, 2002 .

Microbial glycosaminoglycan glycosyltransferases.

P. DeAngelis, 2002, Glycobiology.

Molecular cloning, identification, and sequence of the hyaluronan synthase gene from group A Streptococcus pyogenes.

P. Weigel, J. Papaconstantinou, P. DeAngelis, 1993, The Journal of biological chemistry.

Molecular cloning of the gene encoding RecF, a DNA repair enzyme, from Streptococcus pyogenes.

P. Weigel, N. Yang, P. DeAngelis, 1995, Gene.

The Streptococcus pyogenes hyaluronan synthase: sequence comparison and conservation among various group A strains.

P. Weigel, N. Yang, P. DeAngelis, 1994, Biochemical and biophysical research communications.

Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow

P. DeAngelis, 2012, Applied Microbiology and Biotechnology.

Heparosan-coated liposomes for drug delivery

A. Almond, F. M. Haller, Anais A E Chavaroche, 2017, Glycobiology.

Hyaluronan synthesis in virus PBCV-1-infected chlorella-like green algae.

J. V. Van Etten, D. Burbank, J. Heuser, 1999, Virology.

3.18 – Hyaluronan Biosynthesis Systems from Microbes to Man

P. DeAngelis, 2007 .

Synthesis and characterization of heparosan-granulocyte-colony stimulating factor conjugates: a natural sugar-based drug delivery system to treat neutropenia

A. Almond, D. E. Green, W. Jing, 2017, Glycobiology.

Controlling Nanoparticle Uptake in Innate Immune Cells with Heparosan Polysaccharides.

S. Wilhelm, Wen Yang, Vinit Sheth, 2022, Nano letters.

Defined megadalton hyaluronan polymer standards.

A. Almond, F. M. Haller, W. Jing, 2006, Analytical biochemistry.

Analysis of the two active sites of the hyaluronan synthase and the chondroitin synthase of Pasteurella multocida.

W. Jing, P. DeAngelis, 2003, Glycobiology.

PROFESSIONAL, RESEARCH, AND TEACHING EXPERIENCE:

P. Weigel, C. Glabe, P. DeAngelis, 2012 .

Strong Reduction of the Chain Rigidity of Hyaluronan by Selective Binding of Ca2+ Ions

G. Koenderink, R. Linhardt, B. Ensing, 2020, bioRxiv.

Evaluation of Critical Structural Elements of UDP-Sugar Substrates and Certain Cysteine Residues of a Vertebrate Hyaluronan Synthase*

P. DeAngelis, P. Pummill, 2002, The Journal of Biological Chemistry.

Irreversible Heavy Chain Transfer to Chondroitin*

V. Hascall, Mark E. Lauer, A. Calabro, 2014, The Journal of Biological Chemistry.

Enzymological Characterization of Recombinant XenopusDG42, A Vertebrate Hyaluronan Synthase*

A. M. Achyuthan, P. DeAngelis, P. Pummill, 1998, The Journal of Biological Chemistry.

Hyaluronan in cytosol--microinjection-based probing of its existence and suggested functions.

M. Tammi, R. Tammi, M. Haller, 2013, Glycobiology.

Selective isolation of hyaluronan by solid phase adsorption to silica.

U. Hellman, M. Cowman, X. Ye, 2022, Analytical biochemistry.

Hyaluronan: the absence of amide-carboxylate hydrogen bonds and the chain conformation in aqueous solution are incompatible with stable secondary and tertiary structure models.

A. Almond, C. Blundell, P. DeAngelis, 2006, The Biochemical journal.

Yeast-derived Recombinant DG42 Protein of Xenopus Can Synthesize Hyaluronan in Vitro *

A. M. Achyuthan, P. DeAngelis, 1996, The Journal of Biological Chemistry.

Use of 15N-NMR to resolve molecular details in isotopically-enriched carbohydrates: sequence-specific observations in hyaluronan oligomers up to decasaccharides.

A. Almond, C. Blundell, A. Day, 2004, Glycobiology.

Characterization of the recombinant hyaluronic acid synthase from Streptococcus pyogenes.

P. Weigel, P. DeAngelis, 1995, Developments in biological standardization.

Demonstration of altered cellular DNA content distribution in long-term colon epithelial cell lines with colon cancer genotypes.

M. Melamed, F. Traganos, B. Danes, 1988, Scandinavian journal of gastroenterology.

Analysis of the membrane-interacting domain of the sea urchin sperm adhesive protein bindin.

L. Kennedy, P. DeAngelis, C. Glabe, 1989, Biochemistry.

Irreversible Heavy Chain Transfer to Hyaluronan Oligosaccharides by Tumor Necrosis Factor-stimulated Gene-6*

T. Glant, K. Mikecz, V. Hascall, 2012, The Journal of Biological Chemistry.

A quantitative method for sizing hyaluronan and other glycosaminoglycans on surfaces

Goodenough, L. Djerbal, R. Richter, 2022 .

Structure/Function Analysis of Pasteurella multocida Heparosan Synthases

R. Linhardt, M. Tanner, D. E. Green, 2012, The Journal of Biological Chemistry.

Structure/Function Analysis ofPasteurella multocida Heparosan Synthases TOWARDDEFININGENZYMESPECIFICITYANDENGINEERINGNOVELCATALYSTS *

R. Linhardt, M. Tanner, D. E. Green, 2012 .

Identification of the capsular polysaccharides of Type D and F Pasteurella multocida as unmodified heparin and chondroitin, respectively.

R. Linhardt, T. Toida, Wen-Jun Mao, 2002, Carbohydrate research.

HYALURONAN SYNTHASES: MECHANISTIC STUDIES AND BIOTECHNOLOGICAL APPLICATIONS

P. DeAngelis, 2002 .

Synthesis of uridine 5'-diphosphoiduronic acid: a potential substrate for the chemoenzymatic synthesis of heparin.

R. Linhardt, Jian Liu, M. Weïwer, 2008, The Journal of organic chemistry.

Rapid Chemoenzymatic Synthesis of Monodisperse Hyaluronan Oligosaccharides with Immobilized Enzyme Reactors*

Daniel F Gay, P. DeAngelis, Leonard C Oatman, 2003, Journal of Biological Chemistry.

Chemoenzymatic synthesis of sulfur-linked sugar polymers as heparanase inhibitors

R. Linhardt, Fuming Zhang, Yongmei Xu, 2022, Nature Communications.

Expanding glycosaminoglycan chemical space: towards the creation of sulfated analogs, novel polymers and chimeric constructs

R. Linhardt, Xinyue Liu, C. Schäffer, 2017, Glycobiology.

Plant Detection of Pathogens

P. DeAngelis, A. Ayers, J. J. Goodell, 1985 .

Glycosaminoglycan polysaccharide biosynthesis and production: today and tomorrow

P. DeAngelis, 2012, Applied Microbiology and Biotechnology.

Hyaluronic Acid Production in Bacillus subtilis

P. Weigel, P. Deangelis, B. Widner, 2005, Applied and Environmental Microbiology.

Identification of a Distinct, Cryptic Heparosan Synthase from Pasteurella multocida Types A, D, and F

C. White, P. DeAngelis, 2004, Journal of bacteriology.

Identification and Molecular Cloning of a Heparosan Synthase fromPasteurella multocida Type D*

C. White, P. DeAngelis, 2002, The Journal of Biological Chemistry.

Comamonas testosteronan synthase, a bifunctional glycosyltransferase that produces a unique heparosan polysaccharide analog.

R. Linhardt, Kemal Solakyildirim, N. J. Otto, 2011, Glycobiology.

Exploiting the carboxylate chemical shift to resolve degenerate resonances in spectra of 13C‐labelled glycosaminoglycans

I. Campbell, P. Deangelis, A. Almond, 2005, Magnetic resonance in chemistry : MRC.

Chemoenzymatic synthesis of glycosaminoglycans: re-creating, re-modeling and re-designing nature's longest or most complex carbohydrate chains.

R. Linhardt, Jian Liu, P. DeAngelis, 2013, Glycobiology.

Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycans.

R. Linhardt, Jian Liu, P. Deangelis, 2012, The Journal of organic chemistry.

Specific recognition of sulfate esters by bindin, a sperm adhesion protein from sea urchins.

P. DeAngelis, C. Glabe, 1990, Biochimica et biophysica acta.

Role of basic amino acids in the interaction of bindin with sulfated fucans.

P. DeAngelis, C. Glabe, 1988, Biochemistry.

Initial evaluation of a new epithelial antigen (T16) for bivariate flow cytometry of bladder irrigation specimens.

M. Melamed, C. Cordon-Cardo, W. Fair, 1989, Cytometry.

Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor

A. Skardal, A. Hall, H. Reesink, 2018, Nature Communications.

Transposon Tn916 insertional mutagenesis of Pasteurella multocida and direct sequencing of disruption site.

P. DeAngelis, 1998, Microbial pathogenesis.

Polysaccharide structural features that are critical for the binding of sulfated fucans to bindin, the adhesive protein from sea urchin sperm.

P. DeAngelis, C. Glabe, 1987, The Journal of biological chemistry.

Hyaluronan Synthases: A Decade-plus of Novel Glycosyltransferases*

P. Weigel, P. Deangelis, P. DeAngelis, 2007, Journal of Biological Chemistry.

Chemoenzymatic Design of Heparan Sulfate Oligosaccharides*

R. Linhardt, Yongmei Xu, Jian Liu, 2010, The Journal of Biological Chemistry.

Nanoparticle Toxicology.

S. Wilhelm, Wen Yang, Lin Wang, 2020, Annual review of pharmacology and toxicology.

Hyaluronan synthases: fascinating glycosyltransferases from vertebrates, bacterial pathogens, and algal viruses

P. DeAngelis, 1999, Cellular and Molecular Life Sciences CMLS.

Alteration of Polysaccharide Size Distribution of a Vertebrate Hyaluronan Synthase by Mutation*

P. DeAngelis, P. Pummill, 2003, Journal of Biological Chemistry.

Enzymological characterization of the Pasteurella multocida hyaluronic acid synthase.

P. DeAngelis, 1996, Biochemistry.

43 – AN ENDOGENOUS BACTERIAL PROTEASE SPECIFICALLY CLEAVES A FUSION PROTEIN JUNCTION CONSISTING OF CONSECUTIVE BASIC AMINO ACIDS TO GENERATE A BIOLOGICALLY-ACTIVE EUKARYOTIC ADHESIVE PROTEIN, BINDIN1

C. Glabe, S. Brockman, L. Kennedy, 1989 .

Retention of the mitochondrial probe rhodamine 123 in normal lymphocytes and leukemic cells in relation to the cell cycle.

M. Melamed, M. Kimmel, Z. Darżynkiewicz, 1991, Experimental cell research.

Hyaluronan: the local solution conformation determined by NMR and computer modeling is close to a contracted left-handed 4-fold helix.

Andrew Almond, A. Almond, C. Blundell, 2006, Journal of molecular biology.

Optimizing the sensitivity and resolution of hyaluronan analysis with solid-state nanopores

A. Hall, Elaheh Rahbar, Felipe Rivas, 2022, Scientific Reports.

A quartz crystal microbalance method to quantify the size of hyaluronan and other glycosaminoglycans on surfaces

Goodenough, D. Débarre, P. Deangelis, 2022, Scientific Reports.

Evolution of glycosaminoglycans and their glycosyltransferases: Implications for the extracellular matrices of animals and the capsules of pathogenic bacteria

P. DeAngelis, 2002, The Anatomical record.

Running title: NMR studies of 15 N-enriched hyaluronan oligosaccharides

A. Almond, C. Blundell, A. Day, 2004 .

Hyaluronic acid synthesis, degradation, and crosslinking in equine osteoarthritis: TNF-α-TSG-6-mediated HC-HA formation

M. Paszek, P. Deangelis, A. Hall, 2021, Arthritis Research & Therapy.

Identification of a chondroitin synthase from an unexpected source, the green sulfur bacterium Chlorobium phaeobacteroides

D. E. Green, P. DeAngelis, 2017, Glycobiology.

Hyaluronan synthase of chlorella virus PBCV-1.

J. V. Van Etten, D. Burbank, M. Graves, 1997, Science.

Fibroblast Growth Factor-based Signaling through Synthetic Heparan Sulfate Blocks Copolymers Studied Using High Cell Density Three-dimensional Cell Printing*

R. Linhardt, J. Dordick, Guoyun Li, 2014, The Journal of Biological Chemistry.

Biosynthesis of Hyaluronan

U. Lindahl, M. Kusche‐Gullberg, P. DeAngelis, 2005, Journal of Biological Chemistry.

Identification and Molecular Cloning of a Unique Hyaluronan Synthase from Pasteurella multocida *

R. Drake, W. Jing, P. DeAngelis, 1998, The Journal of Biological Chemistry.

A Refined Model for the TSG-6 Link Module in Complex with Hyaluronan

Benedict M. Sattelle, Victoria A. Higman, B. Sattelle, 2014, The Journal of Biological Chemistry.

The Link Module from Ovulation- and Inflammation-associated Protein TSG-6 Changes Conformation on Hyaluronan Binding*

I. Campbell, P. Teriete, A. Almond, 2003, Journal of Biological Chemistry.

Enzymatic Synthesis of Glycosaminoglycan Heparin

R. Linhardt, J. Dordick, Jian Liu, 2007, Seminars in thrombosis and hemostasis.

Dynamics of hyaluronan oligosaccharides revealed by 15N relaxation.

A. Almond, C. Blundell, P. DeAngelis, 2005, Journal of the American Chemical Society.

Quantifying Intracellular Nanoparticle Distributions with Three-Dimensional Super-Resolution Microscopy.

S. Wilhelm, J. Bewersdorf, Wen Yang, 2023, ACS nano.

Functional Molecular Mass of a Vertebrate Hyaluronan Synthase as Determined by Radiation Inactivation Analysis*

P. Deangelis, E. Kempner, P. E. Pummill, 2001, The Journal of Biological Chemistry.

Zinc specifically stimulates the selective binding of a peptide analog of bindin to sulfated fucans.

P. DeAngelis, C. Glabe, 1990, Peptide research.

Topological Organization of the Hyaluronan Synthase fromStreptococcus pyogenes *

P. Weigel, C. Heldermon, P. DeAngelis, 2001, The Journal of Biological Chemistry.

N-sulfotestosteronan, a novel substrate for heparan sulfate 6-O-sulfotransferases and its analysis by oxidative degradation.

R. Linhardt, Fuming Zhang, Guoyun Li, 2013, Biopolymers.

Label-free analysis of physiological hyaluronan size distribution with a solid-state nanopore sensor

A. Skardal, A. Hall, H. Reesink, 2018, Nature Communications.

Towards a Structure for a TSG-6·Hyaluronan Complex by Modeling and NMR Spectroscopy

I. Campbell, A. Almond, C. Blundell, 2005, Journal of Biological Chemistry.

Enhanced osteoblastic differentiation of mesenchymal stem cells seeded in RGD‐functionalized PLLA scaffolds and cultured in a flow perfusion bioreactor

V. Sikavitsas, J. Álvarez-Barreto, Bonnie C. Landy, 2011, Journal of tissue engineering and regenerative medicine.

Preparation of a functionally flexible, three-dimensional, biomimetic poly(L-lactic acid) scaffold with improved cell adhesion.

V. Sikavitsas, J. Álvarez-Barreto, P. DeAngelis, 2007, Tissue engineering.

THE EFFECT OF SOME WASTE DISPOSAL PRACTICES ON GREAT LAKES WATER QUALITY

H. Chan, P. DeAngelis, R. Ostry, 1980 .

Monodisperse hyaluronan polymers: synthesis and potential applications.

P. DeAngelis, 2008, Current pharmaceutical biotechnology.

Chemoenzymatic synthesis of uridine diphosphate-GlcNAc and uridine diphosphate-GalNAc analogs for the preparation of unnatural glycosaminoglycans.

R. Linhardt, Jian Liu, M. Weïwer, 2012, The Journal of organic chemistry.

Fibroblast Growth Factor-based Signaling through Synthetic Heparan Sulfate Blocks Copolymers Studied Using High Cell Density Three-dimensional Cell Printing*

R. Linhardt, J. Dordick, Guoyun Li, 2014, The Journal of Biological Chemistry.

Chemoenzymatic Design of Heparan Sulfate Oligosaccharides*

R. Linhardt, Yongmei Xu, Jian Liu, 2010, The Journal of Biological Chemistry.

Polysaccharide labeling with N-methylisatoic anhydride: generation of ultraviolet chromophores and blue fluorophores.

P. DeAngelis, 2000, Analytical biochemistry.