W. Knight

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Characterization of pp60c-src tyrosine kinase activities using a continuous assay: autoactivation of the enzyme is an intermolecular autophosphorylation process.

D. Kassel, X. Huang, D. Weigl, 1995, Biochemistry.

Correlation of the phosphorylation states of pp60c-src with tyrosine kinase activity: the intramolecular pY530-SH2 complex retains significant activity if Y419 is phosphorylated.

D. Kassel, S. C. Barker, W. Knight, 1996, Biochemistry.

Electrospray ionization mass spectrometry as a mechanistic tool: mass of human leucocyte elastase and a beta-lactam-derived E-I complex.

B. Shushan, T. Lee, J. Shively, 1993, Biochemistry.

Determination of the kinetic parameters of Escherichia coli leader peptidase activity using a continuous assay: the pH dependence and time-dependent inhibition by beta-lactams are consistent with a novel serine protease mechanism.

P. Griffin, J. Weidner, S. K. Shah, 1994, Biochemistry.

Proteoglycan-degrading activity of human stromelysin-1 and leukocyte elastase in rabbit joints. Quantitation of proteoglycan and a stromelysin-induced HABR fragment of aggrecan in synovial fluid and cartilage.

W. Hagmann, J. Hale, R. Mumford, 1996, Connective tissue research.

Kinetic mechanisms of the forward and reverse pp60c-src tyrosine kinase reactions.

S. C. Barker, W. Knight, R. J. Boerner, 1995, Biochemistry.

Thiol and amino analogues as alternate substrates for glycerokinase from Candida mycoderma.

W. Cleland, W. Knight, 1989, Biochemistry.

Inhibition of human serine proteases by substituted 2-azetidinones.

R. Chabin, W. Knight, B. Green, 1992, Archives of biochemistry and biophysics.

Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives.

W. Hagmann, A. Maycock, J. Doherty, 1992, Biochemistry.

Potency of antileukoprotease and alpha 1-antitrypsin to inhibit degradation of fibrinogen by adherent polymorphonuclear leukocytes from normal subjects and patients with chronic granulomatous disease.

W. Hanlon, J. Stolk, J. Dijkman, 1992, American journal of respiratory cell and molecular biology.

Investigations of the metal ion-binding sites of yeast inorganic pyrophosphatase.

D. Dunaway-Mariano, S. Ransom, J. Villafranca, 1984, The Journal of biological chemistry.

Inhibition of human leukocyte elastase. 3. Synthesis and activity of 3'-substituted cephalosporins.

A. Maycock, J. Doherty, S. K. Shah, 1990, Journal of medicinal chemistry.

Inhibition of human leukocyte elastase. 2. Inhibition by substituted cephalosporin esters and amides.

K. R. Thompson, D. Underwood, M. Navia, 1990, Journal of medicinal chemistry.

SYNTHESIS OF NEW THIAZINOINDOLE DERIVATIVES AND THEIR EVALUATION AS INHIBITORS OF HUMAN LEUKOCYTE ELASTASE AND OTHER RELATED SERINE PROTEASES

R. Chabin, S. Guccione, G. Romeo, 1994 .

Inhibition of human leukocyte elastase by C-2 substituted cephalosporin sulfones

W. Hagmann, A. Maycock, J. Doherty, 1989 .

Synthesis of New Thiazinoindole Derivatives and Their Evaluation as Inhibitors of Human Leukocyte Elastase and Other Related Serine Proteases.

R. Chabin, S. Guccione, G. Romeo, 2010 .

Specificity, stability, and potency of monocyclic beta-lactam inhibitors of human leucocyte elastase.

W. M. Westler, R. Chabin, A. Maycock, 1992, Biochemistry.

Determination of equilibrium 18O isotope effects on the deprotonation of phosphate and phosphate esters and the anomeric effect on deprotonation of glucose 6-phosphate

W. Cleland, P. Weiss, W. Knight, 1986 .

The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo.

K. Lackey, T. Gilmer, E. Wood, 2001, Molecular cancer therapeutics.

Potential of Pyrazolooxadiazinone Derivatives as Serine Protease Inhibitors

V. Andrisano, T. Langer, R. Chabin, 2001, Journal of enzyme inhibition.

SH2- and SH3-mediated Interactions between Focal Adhesion Kinase and Src*

M. Schaller, G. White, W. Knight, 1998, The Journal of Biological Chemistry.

Structural determinants for potent, selective dual site inhibition of human pp60c-src by 4-anilinoquinazolines.

G. Tian, M. Cory, A. A. Smith, 2001, Biochemistry.

Comparison of the Biochemical and Kinetic Properties of the Type 1 Receptor Tyrosine Kinase Intracellular Domains

K. Lackey, K. Blackburn, S. Kadwell, 2002, The Journal of Biological Chemistry.

The characterization of novel, dual ErbB-2/EGFR, tyrosine kinase inhibitors: potential therapy for cancer.

K. Lackey, T. Gilmer, R. Crosby, 2001, Cancer research.

Comparison of the proteoglycanolytic activities of human leukocyte elastase and human cathepsin G in vitro and in vivo.

M. Lark, M. Poe, V. Moore, 1993, Connective tissue research.

Escherichia coli leader peptidase: production of an active form lacking a requirement for detergent and development of peptide substrates.

C. Wilson, P. Griffin, H. Chan, 1993, Archives of biochemistry and biophysics.

Investigation of the regiospecificity and stereospecificity of proton transfer in the yeast inorganic pyrophosphatase catalyzed reaction.

D. Dunaway-Mariano, W. Knight, A. Hsueh, 1986, Biochemistry.

Yeast inorganic pyrophosphatase substrate recognition.

M. Sundaralingam, D. Dunaway-Mariano, W. Knight, 1983, Archives of biochemistry and biophysics.

Investigation of the catalytic mechanism of yeast inorganic pyrophosphatase.

D. Dunaway-Mariano, W. Knight, S. Fitts, 1981, Biochemistry.

Exploration of the Sequence Specificity of pp60c-src Tyrosine Kinase

D. Kassel, M. Luther, S. C. Barker, 1995, The Journal of Biological Chemistry.

Phosphorylated thiosugars: synthesis, properties, and reactivity in enzymatic reactions.

D. Sem, W. Cleland, H. Miziorko, 1991, Biochemistry.

Orally active beta-lactam inhibitors of human leukocyte elastase. 2. Effect of C-4 substitution.

W. Hagmann, A. Maycock, S. K. Shah, 1993, Journal of medicinal chemistry.

X-ray crystallographic and nuclear magnetic resonance spectral studies of the products from the yeast inorganic pyrophosphatase-Co(NH3)4PP reaction. Investigation of the pyrophosphatase reaction mechanism.

M. Sundaralingam, D. Dunaway-Mariano, W. Knight, 1982, Biochemistry.

Investigation of the structure, protonation, and reactivity of tetraammine(imidodiphosphato)cobalt(III), a substrate for potato apyrase

M. Sundaralingam, D. Dunaway-Mariano, W. Knight, 1983 .

Structural and biochemical properties of bidentate tetraaquarhodium(III) complexes of inorganic pyrophosphate and adenosine 5'-diphosphate.

M. Sundaralingam, D. Dunaway-Mariano, W. Knight, 1987, Biochemistry.

PMN elastases: a comparison of the specificity of human isozymes and the enzyme from other species toward substrates and inhibitors.

M. Lark, W. Hagmann, A. Maycock, 1991, Archives of biochemistry and biophysics.

Discovery and biological evaluation of potent dual ErbB-2/EGFR tyrosine kinase inhibitors: 6-thiazolylquinazolines.

K. Lackey, T. Gilmer, R. Griffin, 2003, Bioorganic & medicinal chemistry letters.

Carboxyphosphate; Predicted Chemical Properties, Synthesis and Role as an Intermediate in Enzymic Reactions

W. Knight, 1990 .