Laurel Mydock-McGrane

发表

Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection

J. Pinkner, S. Hultgren, V. Kalas, 2018, Proceedings of the National Academy of Sciences.

Lysosomal cholesterol activates mTORC1 via an SLC38A9–Niemann-Pick C1 signaling complex

R. Zoncu, D. Nomura, D. Ory, 2017, Science.

Patched 1 regulates Smoothened by controlling sterol binding to its extracellular cysteine-rich domain

M. Sansom, R. E. Woolley, C. Siebold, 2022, Science advances.

Structural basis for Smoothened regulation by its extracellular domains

M. Sansom, R. Rambo, C. Siebold, 2016, Nature.

Eliminating the Roughness in Cholesterol’s β-Face: Does it Matter?

P. F. Almeida, Minghui Wang, D. Covey, 2014, Langmuir : the ACS journal of surfaces and colloids.

Development of a bile acid–based newborn screen for Niemann-Pick disease type C

H. Runz, S. Gale, D. Ory, 2016, Science Translational Medicine.

Rational design strategies for FimH antagonists: new drugs on the horizon for urinary tract infection and Crohn’s disease

T. Hannan, J. Janetka, Laurel Mydock-McGrane, 2017, Expert opinion on drug discovery.

Synthesis of a Smoothened Cholesterol: 18,19-Di-nor-cholesterol

D. Covey, Laurel K Mydock-McGrane, N. Rath, 2014, The Journal of organic chemistry.

Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections

J. Pinkner, S. Hultgren, V. Kalas, 2016, Journal of medicinal chemistry.

Tracking the Subcellular Fate of 20(S)-Hydroxycholesterol with Click Chemistry Reveals a Transport Pathway to the Golgi*

P. Schlesinger, D. Ory, Sigrid Nachtergaele, 2014, The Journal of Biological Chemistry.

Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking[S]

S. Gale, D. Ory, J. Schaffer, 2019, Journal of Lipid Research.

Synthesis and characterization of diazirine alkyne probes for the study of intracellular cholesterol trafficking

S. Gale, D. Ory, J. Schaffer, 2019 .

Side-Chain Oxysterols Modulate Cholesterol Accessibility through Membrane Remodeling

Nathan A. Baker, B. Olsen, P. Schlesinger, 2014, Biochemistry.

Photoaffinity labeling with cholesterol analogues precisely maps a cholesterol-binding site in voltage-dependent anion channel-1

Julian P. Whitelegge, J. Janetka, J. Whitelegge, 2017, The Journal of Biological Chemistry.

Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel.

Yusuke Sugasawa, J. Bracamontes, A. Evers, 2019, Biochimica et biophysica acta. Molecular and cell biology of lipids.

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI

J. Pinkner, S. Hultgren, V. Kalas, 2016, ChemMedChem.

Mannose-derived FimH antagonists: a promising anti-virulence therapeutic strategy for urinary tract infections and Crohn’s disease

J. Janetka, Zachary T. Cusumano, Laurel Mydock-McGrane, 2016, Expert opinion on therapeutic patents.

Digital Commons

J. Pinkner, V. Kalas, Michael E. Hibbing, 2022 .