R. Hammer

发表

Use of 1,2,4-dithiazolidine-3,5-dione (DtsNH) and 3-ethoxy-1,2,4-dithiazoline-5-one (EDITH) for synthesis of phosphorothioate-containing oligodeoxyribonucleotides.

K. Musier-Forsyth, G. Bárány, Q. Xu, 1996, Nucleic acids research.

Peptide targeting of platinum anti-cancer drugs.

R. Gambrell, S. Aggarwal, R. Hammer, 2009, Bioconjugate chemistry.

Microwave assisted solid-phase synthesis of substituted tetraazaporphyrins and a phthalocyanine-peptide conjugate

S. Soper, R. Hammer, M. Ndinguri, 2010 .

Efficient acylation of the N-terminus of highly hindered C(alpha)(alpha)-disubstituted amino acids via amino acid symmetrical anhydrides.

Yanwen Fu, R. Hammer, 2002, Organic letters.

Constrained amino acid analogs in de novo peptide design

M. McLaughlin, T. Gauthier, L. Hammarström, 2002 .

Ethyl 2-benzyl-2-nitro-3-phenylpropanoate

F. Fronczek, Yanwen Fu, R. Hammer, 2000 .

Structure - Activity Relationships in Peptide Modulators of β -Amyloid Protein Aggregation: Variation in R , R -Disubstitution Results in Altered Aggregate Size and Morphology

Krystal R. Fontenot, R. McCarley, J. Garno, 2010 .

Five carboxyl-terminal residues of neuregulin2 are critical for stimulation of signaling by the ErbB4 receptor tyrosine kinase

Han Chang, D. Riese, Erika N Blommel, 2004, Oncogene.

Fully 2′‐Deoxy‐2′‐Fluoro Substituted Nucleic Acids Induce RNA Interference in Mammalian Cell Culture

Mandi J. Lopez, W. Monroe, Richard A. Blidner, 2007, Chemical biology & drug design.

β-Amyloid Protein Aggregation

P. Russo, R. McCarley, R. Hammer, 2007 .

Stereospecific Synthesis of trans-2,3-Diaryl Substituted 1-Aminocyclopropanecarboxylic Acid Derivatives

C. Cativiela, Gui-Fa Su, Kai-bei Yu, 2003 .

Controlling Peptide Structure

M. McLaughlin, R. Hammer, T. Yokum, 2010 .

A new approach to phosphonopeptide analogs

R. Hammer, Joseph C. Kappel, M. Fernandez, 2002 .

Synthesis of phosphonopeptide and thiophosphonopeptide analogs as inhibitors of carboxypeptidase A

L. Byers, R. Hammer, H. Fan, 2002 .

Near-infrared heavy-atom-modified fluorescent dyes for base-calling in DNA-sequencing applications using temporal discrimination.

S. Soper, E. Waddell, C. Owens, 1998, Analytical chemistry.

Synthesis of oligonucleotides containing thiazole and thiazole N-oxide nucleobases.

Hannah D. Farquar, F. Fronczek, Arsham Sheybani, 2002, Organic letters.

Universal DNA microarray method for multiplex detection of low abundance point mutations.

N. Gerry, N. Witowski, J. Day, 1999, Journal of molecular biology.

Synthesis of phosphonamides and thiophosphonamides by a one-pot activation-coupling-oxidation protocol

R. Hammer, S. D. Rushing, 2002 .

Sterically Hindered Cα,α-Disubstituted α-Amino Acids: Synthesis from α-Nitroacetate and Incorporation into Peptides

F. Fronczek, M. McLaughlin, L. Hammarström, 2001 .

Practical approach to solid-phase synthesis of C-terminal peptide amides under mild conditions based on a photolysable anchoring linkage.

F. Albericio, G. Bárány, L. Gera, 2009, International journal of peptide and protein research.

Exploring water-soluble Pt(II) complexes of diethylenetriamine derivatives functionalized at the central nitrogen. Synthesis, characterization, and reaction with 5′-GMP

L. Marzilli, F. Fronczek, W. Crowe, 2010 .

Synthesis of phosphonamide and thiophosphonamide dipeptides.

R. Hammer, S. D. Rushing, 2001, Journal of the American Chemical Society.

Synthesis of Phosphonate and Thiophosphonate Esters and Amides from Hydrogen Phosphinates by a Novel One-Pot Activation-Coupling-Oxidation Procedure.

Yen-Hsiang Liu, F. Fronczek, C. Vlaar, 1996 .

Synthesis of Phosphonate and Thiophosphonate Esters and Amides from Hydrogen-Phosphinates by a Novel One-Pot Activation-Coupling-Oxidation Procedure

Yen-Hsiang Liu, C. Vlaar, F. Fronczek, 1995 .

Ethyl Nitroacetate as a Useful Synthon for the Synthesis of Orthogonally Protected, Poly-Functional C αα -Disubstituted Amino Acids

M. McLaughlin, L. Hammarström, Yanwen Fu, 2001 .

Diphenylmethylsilyl Ether (DPMS): A Protecting Group for Alcohols

S. Denmark, E. J. Weber, R. Hammer, 1987 .

Synthetic, Mechanistic, and Structural Studies Related to 1,2,4-Dithiazolidine-3,5-dione.

G. Bárány, Lin Chen, R. Hammer, 1996, The Journal of organic chemistry.

Cyclization of disulfide-containing peptides in solid-phase synthesis.

E. Giralt, C. García-echeverría, F. Albericio, 2009, International journal of peptide and protein research.

Facile Preparation of Protected Furanoid Glycals from Thymidine

M. Cameron, R. Hammer, S. Cush, 1997 .

Improved solid-phase synthesis of α,α-dialkylated amino acid-rich peptides with antimicrobial activity*

P. Elzer, S. Haynes, R. Hammer, 2008 .

Peptides with indirect in vivo activity against an intracellular pathogen: selective lysis of infected macrophages.

P. Elzer, M. McLaughlin, R. Hammer, 2002, The journal of peptide research : official journal of the American Peptide Society.

Application of in situ silylation for improved, convenient preparation of fluorenylmethoxycarbonyl (Fmoc)-protected phosphinate amino acids.

Shunzi Li, R. Hammer, J. K. Whitehead, 2007, The Journal of organic chemistry.

A Convenient Preparation of an Orthogonally Protected Cα,Cα‐Disubstituted Amino Acid Analog of Lysine: 1‐tert‐butyloxycarbonyl‐4‐((9‐fluorenylmethyloxycarbonyl)amino)‐piperidine‐4‐carboxylic Acid

M. McLaughlin, L. Hammarström, Yanwen Fu, 2005 .

Sterically Hindered Cα,α‐Disubstituted α‐Amino Acids: Synthesis from α‐Nitroacetate and Incorporation into Peptides.

M. McLaughlin, Yanwen Fu, F. Fronczek, 2002 .

Approaching real-time molecular diagnostics: single-pair fluorescence resonance energy transfer (spFRET) detection for the analysis of low abundant point mutations in K-ras oncogenes.

Francis Barany, Musundi B Wabuyele, Wieslaw Stryjewski, 2003, Journal of the American Chemical Society.

A 310‐helical pentapeptide in water: Interplay of α,α‐disubstituted amino acids and the central residue on structure formation

D. McElheny, Joohyun Kim, T. Keiderling, 2009, Biopolymers.

Solution and solid structure of a boc-protected piperidine-spiro-hydantoin as studied by two-dimensional NMR and X-ray crystallography

A. D. Bain, P. Hazendonk, J. O. Escobedo, 2004 .

Novel α,α-disubstituted amino acids for peptide secondary structure control

R. Hammer, C. L. Wysong, Muna K. Thalji, 2002 .

Amphipathic α and 310-helical peptides with in vitro and in vivo bioactivity

P. Elzer, M. McLaughlin, T. Gauthier, 2002 .

Amphipathic control of the 310‐/α‐helix equilibrium in synthetic peptides

M. McLaughlin, T. Gauthier, L. Hammarström, 2001 .

310-Helix stabilization via side-chain salt bridges1

M. McLaughlin, T. Gauthier, M. Bursavich, 1998 .

4-Aminopiperidine-4-carboxylic Acid: A Cyclic alpha,alpha-Disubstituted Amino Acid for Preparation of Water-Soluble Highly Helical Peptides.

R. Gundry, M. McLaughlin, G. Morales, 1996, The Journal of organic chemistry.

Vibrational circular dichroism and IR spectral analysis as a test of theoretical conformational modeling for a cyclic hexapeptide.

P. Bouř, Joohyun Kim, T. Keiderling, 2008, Chirality.

Cross-strand coupling of a beta-hairpin peptide stabilized with an Aib-Gly turn studied using isotope-edited IR spectroscopy.

Joohyun Kim, T. Keiderling, J. Kubelka, 2007, Journal of the American Chemical Society.

Side chain and flexibility contributions to the Raman optical activity spectra of a model cyclic hexapeptide.

P. Bouř, T. Keiderling, Josef Kapitán, 2010, The journal of physical chemistry. A.

Nonstereogenic α‐aminoisobutyryl‐glycyl dipeptidyl unit nucleates type I′ β‐turn in linear peptides in aqueous solution

L. Masterson, G. Veglia, G. Bárány, 2007 .

4‐Aminopiperidine‐4‐carboxylic Acid: A Cyclic α,α‐ Disubstituted Amino Acid for Preparation of Water‐Soluble Highly Helical Peptides.

R. Gundry, M. McLaughlin, G. Morales, 1997 .

Biological Activity of Pyrethroid Analogs in Pyrethroid-Susceptible and -Resistant Tobacco Budworms, Heliothis virescens (F.)†

R. P. Hammer, G. Shan, J. Ottea, 1997 .

Chiral tubule self-assembly from an achiral diynoic lipid

B. K. Mishra, B. N. Thomas, R. Hammer, 2003, Proceedings of the National Academy of Sciences of the United States of America.

IR study of cross-strand coupling in a β-hairpin peptide using isotopic labels

T. Keiderling, J. Kubelka, V. Setnička, 2005 .

Stoichiometric Inhibition of Amyloid β-Protein Aggregation with Peptides Containing Alternating α,α-Disubstituted Amino Acids

R. McCarley, Yanwen Fu, R. Hammer, 2006 .

Contrasting In Vivo Effects of Two Peptide-Based Amyloid-β Protein Aggregation Inhibitors in a Transgenic Mouse Model of Amyloid Deposition

D. Morgan, M. Gordon, R. Hammer, 2008, Cell transplantation.

Water Soluble Metallo-Phthalocyanines: The Role of the Functional Groups on the Spectral and Photophysical Properties

Steven A. Soper, Robert P. Hammer, S. Soper, 2007, Journal of Fluorescence.

Binary Solvent Effects in Capillary Zone Electrophoresis with Ultrasensitive Near-IR Fluorescence Detection of Related Tricarbocyanine Dyes and Dye-Labeled Amino Acids

B. Legendre, S. Soper, R. Hammer, 1995 .

Peptide-mediated cell transport of water soluble porphyrin conjugates.

R. P. Hammer, M. Vicente, T. Jensen, 2006, Journal of medicinal chemistry.

Near-infrared, laser-induced fluorescence detection for DNA sequencing applications

Steven A. Soper, Benjamin L. Legendre, James H. Flanagan, 1996 .

Nucleotide analogs and new buffers improve a generalized method to enrich for low abundance mutations.

J. Day, F. Barany, D. Bergstrom, 1999, Nucleic acids research.

Nucleotide analogs facilitate base conversion with 3' mismatch primers.

J. Day, F. Barany, D. Bergstrom, 1999, Nucleic acids research.

Efficient introduction of phosphorothioates into RNA oligonucleotides by 3-ethoxy-1,2,4-dithiazoline-5-one (EDITH).

K. Musier-Forsyth, G. Bárány, Q. Xu, 1996, Nucleic Acids Research.

Unexpectedly Stable (Chlorocarbonyl)(N-ethoxycarbonylcarbamoyl)disulfane, and Related Compounds That Model the Zumach-Weiss-Kühle (ZWK) Reaction for Synthesis of 1,2,4-Dithiazolidine-3,5-diones.

V. Young, G. Bárány, D. Britton, 2015, The Journal of organic chemistry.

Detection of low abundant mutations in DNA using single-molecule FRET and ligase detection reactions

Steven A. Soper, Robert P. Hammer, Francis Barany, 2003, SPIE BiOS.

BioMEMS using electrophoresis for the analysis of genetic mutations

Hannah D. Farquar, S. Soper, G. Thomas, 2002, Expert review of molecular diagnostics.

Selective Modulation of Matrix Metalloproteinase 9 (MMP-9) Functions via Exosite Inhibition*

Robert P. Hammer, Keith Brew, Gregg B. Fields, 2008, Journal of Biological Chemistry.

Functionalized tricarbocyanine dyes as near-infrared fluorescent probes for biomolecules.

James H. Flanagan, S. Soper, S Menchen, 1997, Bioconjugate chemistry.

Near-IR single fluorophore quenching system based on phthalocyanine (Pc) aggregation and its application for monitoring inhibitor/activator action on a therapeutic target: L1-EN.

S. Soper, P. Deininger, I. Nesterova, 2011, The Analyst.

Phthalocyanine dimerization-based molecular beacons using near-IR fluorescence.

S Sibel Erdem, Steven A Soper, S. Soper, 2009, Journal of the American Chemical Society.

Metallo-phthalocyanine near-IR fluorophores: oligonucleotide conjugates and their applications in PCR assays.

Michael W Allen, Steven A Soper, S. Soper, 2007, Bioconjugate chemistry.

Synthesis and cellular studies of nonaggregated water-soluble phthalocyanines.

Kevin M. Smith, R. P. Hammer, Kevin M Smith, 2005, Journal of medicinal chemistry.

Effects of peptides derived from terminal modifications of the aβ central hydrophobic core on aβ fibrillization.

Krystal R. Fontenot, J. Garno, Wilson K. Serem, 2010, ACS chemical neuroscience.

Structure-activity relationships in peptide modulators of β-amyloid protein aggregation: variation in α,α-disubstitution results in altered aggregate size and morphology.

Krystal R. Fontenot, R. McCarley, J. Garno, 2010, ACS chemical neuroscience.

Microarrays assembled in microfluidic chips fabricated from poly(methyl methacrylate) for the detection of low-abundant DNA mutations.

Francis Barany, Wieslaw Stryjewski, Steven A Soper, 2003, Analytical chemistry.

Inter-conversion of neuregulin2 full and partial agonists for ErbB4.

Christopher P Mill, David J Riese, Robert P Hammer, 2007, Biochemical and biophysical research communications.

Enhancing the utility of unnatural amino acid synthetases by manipulating broad substrate specificity.

R. Mehl, D. P. Nguyen, Shigeki J Miyake-Stoner, 2009, Molecular bioSystems.

Synthesis and characterization of positively charged porphyrin-peptide conjugates.

R. P. Hammer, M. Vicente, T. Jensen, 2005, Bioconjugate chemistry.

Capillary and microelectrophoretic separations of ligase detection reaction products produced from low‐abundant point mutations in genomic DNA

Francis Barany, Rondedrick Sinville, Hannah D. Farquar, 2004, Electrophoresis.

Solid-phase synthesis of asymmetrically substituted "AB3-type" phthalocyanines.

S. Soper, I. Nesterova, S. Erdem, 2008, The Journal of organic chemistry.

Mono-amine functionalized phthalocyanines: microwave-assisted solid-phase synthesis and bioconjugation strategies.

S. Soper, I. Nesterova, S. Erdem, 2009, The Journal of organic chemistry.

Micro-DNA sequence analysis using capillary electrophoresis and near-IR fluorescence detection

Steven A. Soper, Benjamin L. Legendre, James H. Flanagan, 1996, Photonics West.

Triple-helical transition state analogues: a new class of selective matrix metalloproteinase inhibitors.

K. Brew, G. Fields, Shunzi Li, 2007, Journal of the American Chemical Society.

Neuregulin isoforms exhibit distinct patterns of ErbB family receptor activation

David J Riese, Han Chang, Robert P Hammer, 2002, Oncogene.

Effects of 1,3-di-o-tolylguanidine (DTG), a sigma ligand, on local cerebral glucose utilization in rat brain

S. L. Patrick, A. Hohmann, J. Walker, 1992, Brain Research.

[DLys6]‐luteinizing hormone releasing hormone–curcumin conjugate inhibits pancreatic cancer cell growth in vitro and in vivo

N. Wakamatsu, W. Hansel, S. Aggarwal, 2011, International journal of cancer.

Efficient synthesis of 1,2,4-dithiazolidine-3,5-diones [dithiasuccinoyl-amines] from bis(chlorocarbonyl)disulfane plus bis(trimethylsilyl)amines.

R. B. Merrifield, M. Barany, R. Hammer, 2005, Journal of the American Chemical Society.

Cyclization of Disulfide‐Containing Peptides in Solid‐Phase Synthesis.

E. Giralt, C. García-echeverría, F. Albericio, 1991 .

Photoinduced RNA interference using DMNPE-caged 2'-deoxy-2'-fluoro substituted nucleic acids in vitro and in vivo.

W. Monroe, K. Svoboda, Richard A. Blidner, 2008, Molecular bioSystems.

Syntheses and cellular studies of water soluble porphyrin-peptide conjugates

Robert P. Hammer, Martha Sibrian-Vazquez, Timothy J. Jensen, 2007, SPIE BiOS.

Improved fidelity of thermostable ligases for detection of microsatellite repeat sequences using nucleoside analogs.

F. Barany, D. Bergstrom, F Barany, 1999, Nucleic acids research.

Simple multiangle, multicorrelator depolarized dynamic light scattering apparatus

R. P. Hammer, P. Russo, Grigor B. Bantchev, 2006 .

Asymmetrical, water-soluble phthalocyanine dyes for covalent labeling of oligonucleotides.

Seok-Hwan Hwang, Christie M Sayes, Steven A Soper, 2002, Bioconjugate chemistry.

Surface-induced aggregation of beta amyloid peptide by co-substituted alkanethiol monolayers supported on gold.

R. McCarley, Robert P Hammer, Robin L McCarley, 2005, Langmuir : the ACS journal of surfaces and colloids.

Vibrational circular dichroism and IR spectral analysis as a test of theoretical conformational modeling for a cyclic hexapeptide.

P. Bouř, Joohyun Kim, T. Keiderling, 2008, Chirality.

Stoichiometric inhibition of amyloid beta-protein aggregation with peptides containing alternating alpha,alpha-disubstituted amino acids.

R. McCarley, Yanwen Fu, R. Hammer, 2006, Journal of the American Chemical Society.

Reversibility of beta-amyloid self-assembly: effects of pH and added salts assessed by fluorescence photobleaching recovery.

P. Russo, R. McCarley, R. Hammer, 2010, Biomacromolecules.